Michelle A. Ozbun
Dr. Michelle A. Ozbun is an established molecular virologist and cancer biologist who has dedicated her career to studying human papillomavirus (HPV) while simultaneously serving as an advocate for LGBTQ+ scientists.[1]
Early life & Education
Dr. Ozbun is the Marilyn S. Budke Endowed Professor of Viral Oncology at the University of New Mexico (UNM).[2] She holds academic positions in the Departments of Molecular Genetics and Microbiology as well as Obstetrics and Gynecology at UNM School of Medicine.[3] She received her PhD from the Baylor College of Medicine's Division of Molecular Virology in 1994 and served in a postdoctoral position at Pennsylvania State University College of Medicine from 1994–1998.[4] Dr. Ozbun was mentored by Drs. Janet S. Butel (Baylor College of Medicine) and Craig Meyers (Pennsylvania State).[5]
Research & Career
Research in Dr. Ozbun's lab centers on HPVs, with focuses on: 1) Investigating viral uptake and interactions on a molecular level; 2) Uncovering the stages of viral infection that influence persistence and progression of diseases; and 3) Elucidating molecular mechanisms of HPV oncoprotein expression and how this translates to cancer progression.[6] Her work has produced three patents, including: 1) Methods for detecting, titering, and determining susceptibility to papillomavirus; 2) Methods for using RhPV as a model for HPV-induced cancers; and 3) Methods of using arginine-rich polypeptide compositions for inhibiting HPV cellular binding.[7] Some of Dr. Ozbun's most recent publications have identified the role of certain signaling events in oncogene expression for HPV tumors,[8] explored HPV infectivity and diagnostic implications in specific patient lesions,[9] and the role of certain GTPases in HPV infection cycles.[10] These scientific advancements utilized various experimental techniques such as culture of cells transfected with HPV, epithelial cell culture, immunohistochemical staining, nucleic acid collection and analysis, protein immunoblotting, flow cytometry, transcription factor activity analysis, and inhibition kinetics assays.[11]
References
- ↑ "500 Queer Scientists".
- ↑ "University of New Mexico Health Sciences (UNMHS)".
- ↑ "500 Queer Scientists".
- ↑ "ResearchGate".
- ↑ "Academic Tree (W3C)".
- ↑ "University of New Mexico Health Sciences (UNMHS)".
- ↑ "University of New Mexico Health Sciences (UNMHS)".
- ↑ Yilmaz, E.; Ozbun, M. A.; Gan, G. N. (2021). "MEK/ERK signaling is a critical regulator of high-risk human papillomavirus oncogene expression revealing therapeutic targets for HPV-induced tumors". Oral Oncology. 116: 105175. doi:10.1016/j.oraloncology.2020.105175. PMC 8519475 Check
|pmc=value (help). PMID 33509683 Check|pmid=value (help). - ↑ Ozbun, M. A.; Bondu, V.; Patterson, N. A.; Sterk, R. T.; Waxman, A. G.; Bennett, E. C.; McKee, R.; Sharma, A.; Yarwood, J.; Rogers, M.; Eichenbaum, G. (2021). "Infectious titres of human papillomaviruses (HPVs) in patient lesions, methodological considerations in evaluating HPV infectivity and implications for the efficacy of high-level disinfectants". EBioMedicine. 63: 103165. doi:10.1016/j.ebiom.2020.103165. PMC 7808919 Check
|pmc=value (help). PMID 33422988 Check|pmid=value (help). - ↑ Young, Jesse M.; Zine El Abidine, Amira; Gómez-Martinez, Ricardo A.; Ozbun, Michelle A. (2019). "The Known and Potential Intersections of Rab-GTPases in Human Papillomavirus Infections". Frontiers in Cell and Developmental Biology. 7: 139. doi:10.3389/fcell.2019.00139. PMC 6702953 Check
|pmc=value (help). PMID 31475144. - ↑ Yilmaz, E.; Ozbun, M. A.; Gan, G. N. (2021). "MEK/ERK signaling is a critical regulator of high-risk human papillomavirus oncogene expression revealing therapeutic targets for HPV-induced tumors". Oral Oncology. 116: 105175. doi:10.1016/j.oraloncology.2020.105175. PMC 8519475 Check
|pmc=value (help). PMID 33509683 Check|pmid=value (help).
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