Mohammad A. Heidaran

Mohammad A. Heidaran

Mohammad (Mo) Heidaran, Ph.D., is an author and a cell biologist who has contributed significantly to the new, emerging field of cell and gene therapy. He holds 25 issued patents in therapeutic stem cells, biological factors, and tissue engineering matrices. He also has an additional 50 patent applications pending. He has authored more than 50 original publications^[1] focused on identifying molecular mechanisms of cellular growth, migration, and differentiation. Notably, he cloned two human genes, Platelet Derived Growth Factor ReceptorPlatelet-derived growth factor, and Transitionary Protein 1 [1]. He received his formal training at the National Cancer Institute, where he was the first to identify the ligand-binding domain of the alpha platelet-derived growth factor receptors and study the role of PI-3 kinase and other key signaling molecules in cell migration and oncogenesis. His work focused on the discovery of the minimal ligand-binding domain of the Platelet Derived Growth Factor Receptors in 1990–1995 (http://www.jbc.org/content/270/46/27595.full.pdf) led to the development of a novel therapeutic concept utilizing the soluble extracellular domain of this family of receptors as a growth factor trap to treat many conditions that involve dysregulation of growth factor production. He is Founder and first Chair of the prestigious, internationally recognized Gordon Research Conference entitled "Signal Transduction by Engineered ECM" (Gordon Research Conferences).

Biography

Heidaran immigrated to the United States from Iran in 1978 during the Islamic Revolution at the age of 16. He graduated with a Ph.D. in Biochemistry from the University of South Carolina and worked at the National Cancer Institute as a Senior Staff Scientist from 1990 to 1996. He then served as Director of R&D in two Fortune 500 companies. He is currently a biologist at the Food and Drug Administration (FDA) with a focus on cell and gene therapy product Current Good Manufacturing Practices (CGMPs).

Honors and Awards:

American Institute of Chemist
National Cancer Institute Technology Award
Phi Kappa Phi National Honor Society
Founder of Gordon Research Conference
Recipient of DARPA award for RBC production
Established islet-beta cell regeneration program at JDRF
Editorial Board of E-biomed and JBMR
Student Athlete of the year UNLV
FDA Regulatory Science Achievement Award

Patents

9,725,694 Composition for collecting and preserving placental stem cells and methods of using the composition
9,598,669 Composition for collecting placental stem cells and methods of using the composition
9,464,274 Methods of generating natural killer cells
9,216,200 Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
9,200,253 Method of producing erythrocytes
8,926,964 Methods of generating natural killer cells
8,728,805 Methods and compositions for treatment of bone defects with placental cell populations
8,638,256 Accuracy and performance of a hybrid positioning system
8,455,250 Co-culture of placental stem cells and stem cells from a second source
8,263,065 Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
8,071,376 Production of oligodendrocytes from placenta-derived stem cells
7,790,458 Material and methods for the growth of hematopoietic stem cells
7,700,090 Co-culture of placental stem cells and stem cells from a second source
7,399,630 Peptides for enhanced cell attachment and growth
7,344,884 Peptides promoting cell adherence, growth and secretion
7,157,275 Peptides for enhanced cell attachment and growth
7,074,615 Peptides for enhanced cell attachment and cell growth
7,070,942 Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5
7,041,506 Peptides promoting cell adherence, growth and secretion
6,967,086 Method for determining the presence or absence of respiring cells on a three-dimensional scaffold
6,932,977 Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4
6,849,606 Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5
6,645,945 Method of treating diseased, injured, or abnormal cartilage with hyaluronic acid and growth factors
6,586,406 Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5
6,309,670 Collagen-polysaccharide matrix for treatment of bone tumors

Publications

Partial

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes, Toshimitsu Matsui, Mohammad Heidaran, Toru Miki, Nicholas Popescu, William La Rochelle, Matthias Kraus, Jacalyn Pierce, and Stuart Aaronson, Science New Series, Vol. 243, No. 4892 (Feb. 10, 1989), pp. 800–804.
Nucleotide sequence of the Stp-1 gene coding for rat spermatid nuclear transition protein 1 (TP1): homology with protamine P1 and assignment of the mouse Stp-1 gene to chromosome 1. Heidaran MA1, Kozak CA, Kistler WS. Gene. 1989 Jan 30;75(1):39-46.
Heidaran, M.A., Showman, R.M., and Kistler, W.S.: In situ hybridization and immunohistology established translational regulation of spermatid transition l messenger RNA. J. Cell Biology 106:1427-1433, 1988.
Heidaran, M.A. and Kistler, W.S.: Post-meiotic transcription and translational regulation of messenger RNA for transition protein l of mammalian spermatids. J. Biol. Chem. 262: 13309–13315, 1987.
Liebmann-Vinson, A., Hemperly, J.A., Guarino, R.D., Spargo, C., and Heidaran, M., Bioactive Extracellular Matrices: Biological and Biochemical Evaluation: Tissue Engineering and Biodegradable Equivalents 2002.
Human placenta-derived adherent cells prevent bone loss, stimulate bone formation, and suppress growth of multiple myeloma in bone. Li X, Ling W, Pennisi A, Wang Y, Khan S, Heidaran M, Pal A, Zhang X, He S, Zeitlin A, Abbot S, Faleck H, Hariri R, Shaughnessy JD Jr, van Rhee F, Nair B, Barlogie B, Epstein J, Yaccoby S. Stem Cells. 2011 Feb;29(2):263-73.
Stem cells in adult tissues. Presnell SC, Petersen B, Heidaran M. Semin Cell Dev Biol. 2002 Oct;13(5):369-76. Review.
Molecular signaling: breakout session summary. Damsky C, Heidaran M, Bottaro D, Crossin K, Ducy P, Ingber D. Ann N Y Acad Sci. 2002 Jun;961:164-7.
Convergence of molecular signaling and tissue engineering. Heidaran MA. Ann N Y Acad Sci. 2002 Jun;961:156-7. Review.
Molecular signaling in bioengineered tissue microenvironments. Bottaro DP, Liebmann-Vinson A, Heidaran MA. Ann N Y Acad Sci. 2002 Jun;961:143-53. Review.
Inductive activity of recombinant human growth and differentiation factor-5. Spiro RC, Liu L, Heidaran MA, Thompson AY, Ng CK, Pohl J, Poser JW. Biochem Soc Trans. 2000;28(4):362-8.
An osteoconductive collagen/hyaluronate matrix for bone regeneration. Liu LS, Thompson AY, Heidaran MA, Poser JW, Spiro RC. Biomaterials. 1999 Jun;20(12):1097-108.
Biological activity of p27kip1 and its amino- and carboxy-terminal domains in G2/M transition of Xenopus oocytes. Font de Mora J, Uren A, Heidaran M, Santos E. Oncogene. 1997 Nov 20;15(21):2541-51.
Carboxyl-terminal domain of p27Kip1 activates CDC2. Uren A, Jakus J, Font de Mora J, Yeudall A, Santos E, Gutkind S, Heidaran MA. J Biol Chem. 1997 Aug 29;272(35):21669-72.
PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells. Alimandi M, Heidaran MA, Gutkind JS, Zhang J, Ellmore N, Valius M, Kazlauskas A, Pierce JH, Li W. Oncogene. 1997 Jul 31;15(5):585-93.
Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. Lopez-Ilasaca M, Li W, Uren A, Yu JC, Kazlauskas A, Gutkind JS, Heidaran MA. Biochem Biophys Res Commun. 1997 Mar 17;232(2):273-7.
Oncogenic activation of the alphaPDGFR defines a domain that negatively regulates receptor dimerization. Uren A, Yu JC, Karcaaltincaba M, Pierce JH, Heidaran MA. Oncogene. 1997 Jan 16;14(2):157-62.
Identification of tyrosine 187 as a protein kinase C-delta phosphorylation site. Li W, Chen XH, Kelley CA, Alimandi M, Zhang J, Chen Q, Bottaro DP, Pierce JH. J Biol Chem. 1996 Oct 18;271(42):26404-9.
Expression of an ATP binding mutant of PKC-delta inhibits Sis-induced transformation of NIH3T3 cells. Li W, Michieli P, Alimandi M, Lorenzi MV, Wu Y, Wang LH, Heidaran MA, Pierce JH. Oncogene. 1996 Aug 15;13(4):731-7.
Identification of a domain within the carboxyl-terminal region of the beta platelet-derived growth factor (PDGF) receptor that mediates the high transforming activity of PDGF. Uren A, Yu JC, Li W, Chung IY, Mahadevan D, Pierce JH, Heidaran MA. J Biol Chem. 1996 May 10;271(19):11051-4.
Structural role of extracellular domain 1 of alpha-platelet-derived growth factor (PDGF) receptor for PDGF-AA and PDGF-BB binding. Mahadevan D, Yu JC, Saldanha JW, Thanki N, McPhie P, Uren A, LaRochelle WJ, Heidaran MA. J Biol Chem. 1995 Nov 17;270(46):27595-600.
Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein. Staebler A, Pierce JH, Brazinski S, Heidaran MA, Li W, Schlegel R, Goldstein DJ. J Virol. 1995 Oct;69(10):6507-17.
An unexpected transforming gene in calf-thymus carrier DNA: bovine hst. Yu JC, DeSeabra AJ, Wang LM, Fleming TP, Chedid M, Miki T, Heidaran MA. Gene. 1995 Sep 11;162(2):333-4.
Differential requirement of a motif within the carboxyl-terminal domain of alpha-platelet-derived growth factor (alpha PDGF) receptor for PDGF focus forming activity chemotaxis, or growth. Yu JC, Li W, Wang LM, Uren A, Pierce JH, Heidaran MA. J Biol Chem. 1995 Mar 31;270(13):7033-6.
Lee, M.H., Au, P., Hyde, J., Gacchina-Johnson, C., Heidaran, M., Karandish, S., Boxer, L., Mendicino, M., Yoon, D., Tull, L., Arcidiacono, J., McCright, B., Kaplan, D.S., Fink, D., Durfor, C., McFarland, R., and Witten, C. Translation of Regenerative Medicine Products Into the Clinic in the United States: FDA Perspective, Translational Regenerative Medicine, 2014.

References:

↑ Heidaran, Mohammad (2/10/1989). "Isolation of a novel receptor cDNA establishes the existence of two PDGF Receptor Genes". Science. 243: 800–804. Check date values in: |date= (help)

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[1] Heidaran, Mohammad (2/10/1989). "Isolation of a novel receptor cDNA establishes the existence of two PDGF Receptor Genes". Science. 243: 800–804. Check date values in: |date= (help)

[1]