Muscimol Hydrobromide
| File:Muscimol Hydrobromide.png | |
| Clinical data | |
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| Synonyms | 3(2H)-Isoxazolone, 5-(aminomethyl)-, monohydrobromide
5-(Aminomethyl)-3(2H)-isoxazolone hydrobromide 5-(Aminomethyl)-3-isoxazolol monohydrobromide |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| UNII | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}} |
| Chemical and physical data | |
| Formula | C4H7BrN2O2 |
| Molar mass | 195.01 |
| 3D model (JSmol) | |
| Solubility in water | 303.0 mg/mL (20 °C) |
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Muscimol Hydrobromide is the hydrogen bromide salt form of the psychoactive compound muscimol (3-hydroxy-5-aminomethylisoxazole), a potent GABA receptor agonist.[1][2]
This form of muscimol salt is more stable than classical muscimol and is usually used only for experimental purposes; it is the parent substance of muscimol.[2][1]
General information
Unlike muscimol, it is a highly toxic substance and is used in neurobiological research.[3]
Due to its agonist activity at certain receptor sites, it plays a key role in the study of receptor function in the regulation of neuronal excitability and synaptic transmission. The use of muscimol hydrobromide in brain slice preparations provides insight into the regional and cellular distribution of these receptors in the central nervous system.[3]
Toxicity status
Despite all the notes, muscimol hydrobromide is a highly toxic substance; it is listed in the Laboratory Chemical Safety Summary (LCSS) Datasheet as acutely toxic when taken orally.[1]
References
- ↑ 1.0 1.1 1.2 PubChem. "Muscimol Hydrobromide". pubchem.ncbi.nlm.nih.gov. Retrieved 2025-09-17.
- ↑ 2.0 2.1 "Muscimol hydrobromide | DrugBank Online". go.drugbank.com. Retrieved 2025-09-17.
- ↑ 3.0 3.1 SCBT. "Muscimol hydrobromide | CAS 18174-72-6 | SCBT - Santa Cruz Biotechnology". www.scbt.com. Retrieved 2025-09-17.
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