N1-methyl-pseudouridine
From EverybodyWiki Bios & Wiki
N1-methyl-pseudouridine is a derivative of the nucleoside uridine in which the uracil is attached via a carbon-carbon instead of a nitrogen-carbon glycosidic bond, and a methyl group attached to the nitrogen at the 1 position of uridine.
In the SARS-CoV-2 vaccine from BioNTech/Pfizer, also known as BNT162b2, Tozinameran or Comirnaty, all U’s have been substituted with N1-methyl-pseudouridine.[1]
References
- ↑ "European medicines Agency Assessment report on Comirnaty (Common name: COVID-19 mRNA vaccine) (nucleoside-modified) Procedure No. EMEA/H/C/005735/0000" (PDF). 2021-02-19. Unknown parameter
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