Nehal N. Mehta
Removed and re-referenced
No conflict of interest.
| Nehal N. Mehta | |
|---|---|
 Nehal N. Mehta.jpg | |
| Born | November 30, 1975 Mumbai, India |
| 🎓 Alma mater | George Washing University School of Medicine Oxford University University of Pennsylvania Perelman School of Medicine |
| 💼 Occupation | |
| 🏅 Awards | Lasker Clinical Scholar (2012) NHLBI Director's Award (2017) NHLBI Orloff Science Award (2018) NIH Director's Award (2018) |
Nehal N. Mehta is an American cardiologist, who has made significant contributions to the field of inflammation and cardiovascular disease by using a chronic inflammatory model to study the role of inflammation in atherosclerosis. He is the first Lasker Clinical Research Scholar Awardee.[1] at the National Institutes of Health (NIH) and is presently Head, Laboratory of Inflammation and Cardiometabolic Disease [2] at the National Heart, Lung, and Blood Institute (NHLBI) in Bethesda, Maryland, United States of America.
Biography
Nehal N. Mehta directs a prospective cohort study of psoriasis patients at the NIH [3]. Dr. Mehta was the first to use inflammatory imaging through positron emission tomography to demonstrate that patients with psoriasis have early onset of vascular inflammation, the premise of his current research program [4]. He also applies cardiovascular imaging techniques to immunological studies in order to advance understanding of the role of the immune system and inflammation in heart disease.
Early Life, Family and Interests
Dr. Mehta was born in Mumbai, India in 1975 but moved to New Jersey, United States of America when he was one year old. His father, an internist, and gastroenterologist, and mother, their practice manager strongly valued education, leadership and service. His brother is also a cardiologist. Dr. Mehta enjoys surfing, skiing, cooking and playing tennis.
Education and Career
Dr. Mehta attended The George Washington University’s 7-year biomedical program and received his Bachelor of Arts in 1997 with Honors and Doctor of Medicine degree in 2001 with Distinction [5]. He spent time in 1997 studying Biochemistry at Oxford University, United Kingdom before starting medical school. He then completed a residency in internal medicine, fellowship in cardiovascular diseases, nuclear cardiology, and a post-doctoral fellowship in genetic epidemiology at the Hospital of the University of Pennsylvania where he joined in 2007 as the Director of the Inflammatory Risk in Preventive Cardiology [6]. Initially, Dr. Mehta focused on the role of inflammation in obesity and performed seminal studies demonstrating that acute inflammation led to adipose inflammation. Then in 2009, he extended these findings by collaborating with Dr. Joel Gelfand to understand why psoriasis, an inflammatory skin disease increased risk for heart attack [7]. To deeply characterize this link, Dr. Mehta successfully wrote and received the first Lasker Clinical Scholar Award which moved his program from the University of Pennsylvania to the NIH. In 2012, the Albert and Mary Lasker Foundation and the NIH named him the inaugural Lasker Investigator, enabling Dr. Mehta to create a laboratory focusing on the role of inflammation in cardiometabolic diseases at the NIH. Dr. Francis Collins, Director of the NIH, then commented that "Dr. Mehta is an exceptional early-career scientist who will be a tremendous addition to the NIH Intramural Research Program” [8].
Current Work and Achievements
Following epidemiological observations of accelerated heart attack risk in psoriasis, Dr. Mehta’s research program has spent the past decade dissecting why this may occur. Prior work demonstrated that both aortic vascular inflammation and coronary artery plaque occur about a decade earlier in psoriasis compared to non-psoriasis [9]. Furthermore, cholesterol transport is dysfunctional which in the face of systemic inflammation and immune dysregulation drives early cholesterol crystal formation. Most recent work has focused on trying to elucidate whether treatment of the skin disease in psoriasis can reverse vascular diseases. To date, he has authored more than 150 peer-reviewed manuscripts [10]. His most recent discovery that “treatment with systemic anti-inflammatory medications improve lipid-rich coronary plaque in inflammatory diseases such as psoriasis” earned him both an NIH Director’s Awards and an NHLBI Orloff Science Award.
Honors and Awards
- 2000: William Beaumont Research Honors Society, The George Washington University
- 2006: American College of Cardiology/Merck Award for Metabolic Syndrome Research
- 2010: Jeremiah Stammler Research Award, Northwestern University Young Investigators Symposium
- 2012: Lasker Clinical Research Scholar Award, NHLBI, NIH
- 2014: NHLBI Director’s Award: Outstanding Clinical Research
- 2017: NHLBI Director’s Award: Outstanding Clinical Research
- 2018: NHLBI Orloff Science Award: Inflammation and Atherosclerosis
- 2018: The American Society for Clinical Investigation
- 2018: NIH Director’s Award: Science/Medical Award
Dr. Mehta has been a visiting professor at many medical and research institutes.
Notable Publications
- Mehta NN,...Gelfand JM (June 2018). Effect of 2 Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial. Circ Cardiovasc Imaging. 2018 Jun;11(6):e007394 [11].
- Baumer Y,...Mehta NN. Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis. JCI Insight. 2018 Jan 11;3(1). pii: 97179.[12]
- Mehta NN,...Gudjonsson JE. IFN-γ and TNF-α synergism may provide a link between psoriasis and inflammatory atherogenesis. Sci Rep. 2017 Oct 23;7(1):13831 [13].
- Lerman JB,...Mehta NN. Coronary Plaque Characterization in Psoriasis Reveals High-Risk Features That Improve After Treatment in a Prospective Observational Study. Circulation. 2017 Jul 18;136(3):263-276. Epub 2017 May 8 [9].
- Sajja AP,...Mehta NN. Potential Immunological Links Between Psoriasis and Cardiovascular Disease. Frontiers of Immunology. 2018 June 1; 9: 1234 [14]
References
- ↑ Schubert, Charlotte (August 16, 2012). "Turning point: Nehal Mehta". Nature. 488 (7411): 421–421. doi:10.1038/nj7411-421a – via www.nature.com.
- ↑ "Principal Investigators". NIH Intramural Research Program. Archived from the original on 2019-12-31. Retrieved 2019-04-03.
- ↑ Harrington, Charlotte L.; Dey, Amit K.; Yunus, Raza; Joshi, Aditya A.; Mehta, Nehal N. (March 3, 2017). "Psoriasis as a human model of disease to study inflammatory atherogenesis". American Journal of Physiology-Heart and Circulatory Physiology. 312 (5): H867–H873. doi:10.1152/ajpheart.00774.2016. PMC 5451578. PMID 28258057 – via physiology.org (Atypon).
- ↑ Gelfand, Joel M.; Alavi, Abass; Torigian, Drew A.; Voorhees, Abby S. Van; Antigua, Jules; Baer, Amanda; Raper, Anna; Krishnamoorthy, Parasuram; Foroughi, Negar; Saboury, Babak; Yu, YiDing; Mehta, Nehal N. (September 1, 2011). "Systemic and Vascular Inflammation in Patients With Moderate to Severe Psoriasis as Measured by [18F]-Fluorodeoxyglucose Positron Emission Tomography –Computed Tomography (FDG-PET/CT): A Pilot Study". Archives of Dermatology. 147 (9): 1031–1039. doi:10.1001/archdermatol.2011.119 – via jamanetwork.com.
- ↑ "Faculty Directory | The School of Medicine & Health Sciences | The George Washington University". www.gwumc.edu.
- ↑ "Nehal N. Mehta | Faculty | Members | Penn Institute for Immunology | Perelman School of Medicine at the University of Pennsylvania". www.med.upenn.edu.
- ↑ Gelfand, Joel M.; Neimann, Andrea L.; Shin, Daniel B.; Wang, Xingmei; Margolis, David J.; Troxel, Andrea B. (October 11, 2006). "Risk of myocardial infarction in patients with psoriasis". JAMA. 296 (14): 1735–1741. doi:10.1001/jama.296.14.1735. PMID 17032986 – via PubMed.
- ↑ "NIH and Lasker Foundation announce first Clinical Research Scholar". National Institutes of Health (NIH). August 31, 2015.
- ↑ 9.0 9.1 Lerman, Joseph B.; Joshi, Aditya A.; Chaturvedi, Abhishek; Aberra, Tsion M.; Dey, Amit K.; Rodante, Justin A.; Salahuddin, Taufiq; Chung, Jonathan H.; Rana, Anshuma; Teague, Heather L.; Wu, Jashin J.; Playford, Martin P.; Lockshin, Benjamin A.; Chen, Marcus Y.; Sandfort, Veit; Bluemke, David A.; Mehta, Nehal N. (July 18, 2017). "Coronary Plaque Characterization in Psoriasis Reveals High-Risk Features That Improve After Treatment in a Prospective Observational Study". Circulation. 136 (3): 263–276. doi:10.1161/CIRCULATIONAHA.116.026859. PMC 5534138. PMID 28483812 – via PubMed.
- ↑ "nehal mehta - PubMed - NCBI". www.ncbi.nlm.nih.gov.
- ↑ Mehta, Nehal N.; Shin, Daniel B.; Joshi, Aditya A.; Dey, Amit K.; Armstrong, April W.; Duffin, Kristina Callis; Fuxench, Zelma Chiesa; Harrington, Charlotte L.; Hubbard, Rebecca A.; Kalb, Robert E.; Menter, Alan; Rader, Daniel J.; Reilly, Muredach P.; Simpson, Eric L.; Takeshita, Junko; Torigian, Drew A.; Werner, Thomas J.; Troxel, Andrea B.; Tyring, Stephen K.; Vanderbeek, Suzette Baez; Van Voorhees, Abby S.; Playford, Martin P.; Ahlman, Mark A.; Alavi, Abass; Gelfand, Joel M. (June 28, 2018). "Effect of 2 Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial". Circulation. Cardiovascular Imaging. 11 (6): e007394. doi:10.1161/CIRCIMAGING.117.007394. PMC 5991103. PMID 29776990 – via PubMed.
- ↑ Baumer, Y; Ng, Q; Sanda, GE; Dey, AK; Teague, HL; Sorokin, AV; Dagur, PK; Silverman, JI; Harrington, CL; Rodante, JA; Rose, SM; Varghese, NJ; Belur, AD; Goyal, A; Gelfand, JM; Springer, DA; Bleck, CK; Thomas, CL; Yu, ZX; Winge, MC; Kruth, HS; Marinkovich, MP; Joshi, AA; Playford, MP; Mehta, NN (11 January 2018). "Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis". JCI insight. 3 (1). doi:10.1172/jci.insight.97179. PMID 29321372.
- ↑ Mehta, Nehal N.; Teague, Heather L.; Swindell, William R.; Baumer, Yvonne; Ward, Nicole L.; Xing, Xianying; Baugous, Brooke; Johnston, Andrew; Joshi, Aditya A.; Silverman, Joanna; Barnes, Drew H.; Wolterink, Liza; Nair, Rajan P.; Stuart, Philip E.; Playford, Martin; Voorhees, John J.; Sarkar, Mrinal K.; Elder, James T.; Gallagher, Katherine; Ganesh, Santhi K.; Gudjonsson, Johann E. (October 23, 2017). "IFN-γ and TNF-α synergism may provide a link between psoriasis and inflammatory atherogenesis". Scientific Reports. 7 (1): 13831. doi:10.1038/s41598-017-14365-1. PMC 5653789. PMID 29062018 – via PubMed.
- ↑ Sajja, Aparna P.; Joshi, Aditya A.; Teague, Heather L.; Dey, Amit K.; Mehta, Nehal N. (March 28, 2018). "Potential Immunological Links Between Psoriasis and Cardiovascular Disease". Frontiers in Immunology. 9: 1234. doi:10.3389/fimmu.2018.01234. PMC 5992299. PMID 29910818 – via PubMed.
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