NeoCardioLab
NeoCardioLab
The NeoCardioLab is run by Dr. Gabriel Altit, neonatologist at the Montreal Children's Hospital of the McGill University Health Center (MUHC). It is part of the Child Health and Human Development Program (CHHD).[1][2] of the McGill University Health Centre Research Institute (MUHC-RI)[3], in Montreal, Canada. The NeoCardioLab does research in neonatal hemodynamics, with a particular interest in neonatal echocardiography. The principal investigator has trained at McGill University (medicine - MDCM program), Université de Montréal and CHU Sainte-Justine (pediatrics and neonatology), pediatric echocardiography (McGill University) and completed post-doctoral training in research echocardiography at Stanford University - Lucile Packard Children's Hospital. Following this, Dr. Gabriel Altit joined the neonatology division of the Montreal Children's Hospital and completed a Master's in Epidemiology at McGill University[4]. Dr Altit has published numerous peer-reviewed article on neonatal hemodynamics (PubMed link).
Since his appointment as clinician-scientist at the MUHC-RI, Dr Gabriel Altit has created the NeoCardioLab (www.neocardiolab.com). The NeoCardioLab has numerous prospective studies, some of which are multi-centric. Research involves the use of echocardiography, point of care ultrasound, lung ultrasound and brain ultrasound, as well as near infrared spectroscopy.
Application - Iphone / Android
In 2021, the NeoCardioLab has launched a free application available for Iphone/Ipad and Android [5]. The application and website offer educational material on neonatal echocardiography, congenital heart defect, near infrared spectroscopy, neonatal research, neonatal epidemiology and point of care ultrasound (POCUS). The NeoCardioLab portal has an atlas of neonatal congenital heart defects. It also provides a "normal" neonatal echocardiography divided by views (parasternal long axis, parasternal short axis, apical views, patent ductus arteriosus view, suprasternal view and subcostal/subxyphoid view). Since 2021, the NeoCardioLab portal also has a family section, allowing for a variety of resources pertaining to neonatology and tailored to families' needs, such as: interviews, skin to skin care, breastfeeding and developmental care.
Advanced echocardiography techniques
Although the NeoCardioLab has an interest in targeted neonatal echocardiography (TnECHO) and POCUS, it also uses advanced imaging techniques for research purposes, such as speckle-tracking echocardiography (STE), tissue Doppler imaging and 3D echocardiography. There are modules on the NeoCardioLab portal explaining the use of STE and 3D echocardiography in the context of neonatal research.
Fellowship
In 2020, as part of the Neonatology program of McGill University, the NeoCardioLab offers the Neonatal Hemodynamics Clinical Research Fellowship. Dr Gabriel Altit is the program director of this post-doctoral clinical-research training year[6].
Neonatal NIRS Consortium
Since 2021, the NeoCardioLab portal hosts the Neonatal NIRS International Consortium, led by Dr. Valerie Chock from Stanford University, Dr. Jonathan Mintzer from Mountainside Medical Center, and Dr Zachary Vesoulis from Washington University in St. Louis[7].
Discoveries
Prematurity
NeoCardioLab has described a population of extreme premature newborns born at less than 26 weeks gestational age and exposed to a conservative policy regarding patent ductus management. The study demonstrated that the ductus tends to spontaneously close in the majority of premature newborns[8]. The NeoCardioLab has also described the impact of being born premature on the cardiac remodelling lasting up to adulthood[9][10][11]. Pulmonary hypertension is a complication described in the context of extreme prematurity and chronic lung disease[12][13][14][15]. In these infants, the NeoCardioLab has described that echocardiographic markers of ventricular function at the diagnosis of pulmonary hypertension is associated with later mortality[16].
Near Infared Spectroscopy (NIRS)
The NeoCardioLab provides resources regarding neonatal NIRS monitoring. The NeoCardioLab has described that cerebral and renal end-organ saturations were associated with the Doppler profile of the aortic blood flow on echocardiography in the extremely preterm newborn [17]. The NeoCardioLab has also described that the Doppler profile of the anterior cerebral artery corresponds to the instantaneous measures of cerebral saturation by NIRS in the extreme premature newborn[18]. In the congenital heart defect population, cerebral and renal saturations by NIRS were found to be disturbed in those with a single ventricular physiology compared to normal newborns [19]
Echocardiography as a predictor of outcomes
NeoCardioLab publications have concentrated on evaluating echocardiography as a predictor of outcomes in various neonatal populations. In hypoplastic left heart syndrome (HLHS), the immediate post-natal right ventricular cardiac performance assessed by echocardiography was associated with adverse outcomes [20]. Indeed, a decreased in right ventricular stroke distance by velocity time integral and a decreased tricuspid annular plane systolic excursion on the echocardiography at day 1 of life was associated with increased death or cardiac transplantation [20]. Also, newborns with congenital diaphragmatic hernia (CDH) were found to have signs of decreased left ventricular size and performance, which was associated with an increased risk of death or need for extracorporeal membrane oxygenation (ECMO) . Further, inhaled nitric oxide (iNO), a pulmonary vasodilator often used in the context of persistent pulmonary hypertension of the newborn, was found to not be effective in improving the combined outcome of death or ECMO in those with CDH [21]. Neonatal echocardiographic markers of cardiac dysfunction were also described of adverse outcomes in the omphalocele [22] and hypoxic ischemic encephalopathy[23] populations.
References
- ↑ "Child Health and Human Development - Research Institute of the McGill University Health Centre - RI-MUHC". Research Institute of the McGill University Health Centre. Retrieved 2021-12-24.
- ↑ "RESEARCHERS (OLD) | chhdprogram". www.chhd-program.com. Retrieved 2021-12-25.
- ↑ "Gabriel Altit, MDCM, MSc, FRCPC, FAAP - Research Institute of the McGill University Health Centre - RI-MUHC". Research Institute of the McGill University Health Centre. Retrieved 2021-12-25.
- ↑ "NeoCardio Lab - Principal Investigator". www.neocardiolab.com. Retrieved 2021-12-24.
- ↑ "NeoCardioLab". App Store. Retrieved 2021-12-25.
- ↑ "Fellowship by the Post-Graduate Medical Education Office". McGill University. 2021. Unknown parameter
|url-status=ignored (help) - ↑ "NeoCardio Lab - Neonatal NIRS Consortium". www.neocardiolab.com. Retrieved 2021-12-24.
- ↑ de Carvalho Nunes, Gabriela; Wutthigate, Punnanee; Simoneau, Jessica; Beltempo, Marc; Sant'Anna, Guilherme Mendes; Altit, Gabriel (2021-11-23). "Natural evolution of the patent ductus arteriosus in the extremely premature newborn and respiratory outcomes". Journal of Perinatology: Official Journal of the California Perinatal Association. doi:10.1038/s41372-021-01277-2. ISSN 1476-5543. PMID 34815521 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Dartora, Daniela Ravizzoni; Flahault, Adrien; Luu, Thuy Mai; Cloutier, Anik; Simoneau, Jessica; White, Michel; Lapointe, Anie; Villeneuve, Andréanne; Bigras, Jean-Luc; Altit, Gabriel; Nuyt, Anne Monique (July 2021). "Association of Bronchopulmonary Dysplasia and Right Ventricular Systolic Function in Young Adults Born Preterm". Chest. 160 (1): 287–296. doi:10.1016/j.chest.2021.01.079. ISSN 1931-3543. PMID 33549599 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Lasry, Ariane; Kavabushi, Patrick; Canakis, Anne-Marie; Luu, Thuy M.; Nuyt, Anne-Monique; Perreault, Thérèse; Simoneau, Jessica; Landry, Jennifer; Altit, Gabriel (2021-01-17). "Cardiopulmonary Function Abnormalities in Cohort of Adults following Bronchopulmonary Dysplasia as Preterm Infants". American Journal of Perinatology. doi:10.1055/s-0040-1722604. ISSN 1098-8785. PMID 33454944 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Flahault, Adrien; Altit, Gabriel; Sonea, Aurélie; Gervais, Anne-Sophie; Mian, Muhammad Oneeb Rehman; Wu, Rong; Desbrousses, Eva; Mai, Ly; Cloutier, Anik; Simoneau, Jessica; Lapointe, Anie (2021-04-18). "Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics". Journal of Clinical Medicine. 10 (8): 1760. doi:10.3390/jcm10081760. ISSN 2077-0383. PMC 8072582 Check
|pmc=value (help). PMID 33919540 Check|pmid=value (help). - ↑ Altit, Gabriel; Dancea, Adrian; Renaud, Claudia; Perreault, Thérèse; Lands, Larry C.; Sant'Anna, Guilherme (June 2017). "Pathophysiology, screening and diagnosis of pulmonary hypertension in infants with bronchopulmonary dysplasia - A review of the literature". Paediatric Respiratory Reviews. 23: 16–26. doi:10.1016/j.prrv.2016.11.002. ISSN 1526-0550. PMID 27986502.
- ↑ Hébert, Audrey; Drolet, Christine; Altit, Gabriel; Villeneuve, Andréanne; Lapointe, Anie; Bensouda, Brahim; Giesinger, Regan E.; McNamara, Patrick J. (Nov 2020). "Management of chronic pulmonary hypertension in neonates with bronchopulmonary dysplasia: perspectives of neonatologists with hemodynamic expertise and pediatric cardiologists". Journal of Perinatology: Official Journal of the California Perinatal Association. 40 (11): 1726–1728. doi:10.1038/s41372-020-00791-z. ISSN 1476-5543. PMID 32801352 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Altit, Gabriel; Bhombal, Shazia; Hopper, Rachel K.; Tacy, Theresa A.; Feinstein, Jeffrey (Mar 2019). "Death or resolution: the "natural history" of pulmonary hypertension in bronchopulmonary dysplasia". Journal of Perinatology: Official Journal of the California Perinatal Association. 39 (3): 415–425. doi:10.1038/s41372-018-0303-8. ISSN 1476-5543. PMID 30617286. Unknown parameter
|s2cid=ignored (help) - ↑ Altit, Gabriel; Lee, Henry C.; Hintz, Susan; Tacy, Theresa A.; Feinstein, Jeffrey A.; Bhombal, Shazia (Apr 2018). "Practices surrounding pulmonary hypertension and bronchopulmonary dysplasia amongst neonatologists caring for premature infants". Journal of Perinatology: Official Journal of the California Perinatal Association. 38 (4): 361–367. doi:10.1038/s41372-017-0025-3. ISSN 1476-5543. PMID 29234146. Unknown parameter
|s2cid=ignored (help) - ↑ Altit, Gabriel; Bhombal, Shazia; Feinstein, Jeffrey; Hopper, Rachel K.; Tacy, Theresa A. (July 2019). "Diminished right ventricular function at diagnosis of pulmonary hypertension is associated with mortality in bronchopulmonary dysplasia". Pulmonary Circulation. 9 (3): 2045894019878598. doi:10.1177/2045894019878598. ISSN 2045-8932. PMC 6792284 Check
|pmc=value (help). PMID 31662848. - ↑ Altit, Gabriel; Bhombal, Shazia; Chock, Valerie Y. (2021-07-12). "End-organ saturations correlate with aortic blood flow estimates by echocardiography in the extremely premature newborn - an observational cohort study". BMC Pediatrics. 21 (1): 312. doi:10.1186/s12887-021-02790-1. ISSN 1471-2431. PMC 8274006 Check
|pmc=value (help). PMID 34253175 Check|pmid=value (help). - ↑ Altit, Gabriel; Bhombal, Shazia; Chock, Valerie Y. (2021-07-10). "Cerebral saturation reflects anterior cerebral artery flow parameters by Doppler ultrasound in the extremely premature newborn". Journal of Perinatology: Official Journal of the California Perinatal Association. 42 (2): 237–242. doi:10.1038/s41372-021-01145-z. ISSN 1476-5543. PMID 34247188 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Altit, Gabriel; Bhombal, Shazia; Tacy, Theresa A.; Chock, Valerie Y. (2018). "End-Organ Saturation Differences in Early Neonatal Transition for Left- versus Right-Sided Congenital Heart Disease". Neonatology. 114 (1): 53–61. doi:10.1159/000487472. ISSN 1661-7819. PMID 29649824. Unknown parameter
|s2cid=ignored (help) - ↑ 20.0 20.1 Altit, Gabriel; Bhombal, Shazia; Chock, Valerie Y.; Tacy, Theresa A. (Jan 2019). "Immediate Postnatal Ventricular Performance Is Associated with Mortality in Hypoplastic Left Heart Syndrome". Pediatric Cardiology. 40 (1): 168–176. doi:10.1007/s00246-018-1974-9. ISSN 1432-1971. PMID 30178190. Unknown parameter
|s2cid=ignored (help) - ↑ Altit, Gabriel; Bhombal, Shazia; Van Meurs, Krisa; Tacy, Theresa A. (Dec 2017). "Ventricular Performance is Associated with Need for Extracorporeal Membrane Oxygenation in Newborns with Congenital Diaphragmatic Hernia". The Journal of Pediatrics. 191: 28–34.e1. doi:10.1016/j.jpeds.2017.08.060. ISSN 1097-6833. PMID 29037794. Unknown parameter
|s2cid=ignored (help) - ↑ Dal Col, Alexis K.; Bhombal, Shazia; Tacy, Theresa A.; Hintz, Susan R.; Feinstein, Jeffrey; Altit, Gabriel (Aug 2021). "Comprehensive Echocardiographic Assessment of Ventricular Function and Pulmonary Pressure in the Neonatal Omphalocele Population". American Journal of Perinatology. 38 (S 01): e109–e115. doi:10.1055/s-0040-1708048. ISSN 1098-8785. PMID 32198744 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Altit, Gabriel; Bonifacio, Sonia L.; Guimaraes, Carolina V.; Bhombal, Shazia; Sivakumar, Ganesh; Yan, Beth; Chock, Valerie; Meurs, Krisa V. (2021-09-07). "Cardiac Dysfunction in Neonatal HIE Is Associated with Increased Mortality and Brain Injury by MRI". American Journal of Perinatology. doi:10.1055/s-0041-1735618. ISSN 1098-8785. PMID 34492719 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help)
External links
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