Netz Arroyo
Netzahualcóyotl (“Netz”) Arroyo Currás is a Mexican-American chemist known for his contributions to electrochemical biosensing, continuous molecular monitoring, and analytical chemistry. He is an Associate Professor of Chemistry at the University of North Carolina at Chapel Hill,[1] having previously served on the faculty of the Johns Hopkins University School of Medicine.[2]
Early life and education
Netz was born in Puebla, Mexico, where he completed his early education before moving to Monterrey to pursue undergraduate studies at Tecnológico de Monterrey, earning a B.S. in Chemical Sciences (LCQ) in 2009. He received his Ph.D. in Analytical Chemistry from the University of Texas at Austin in 2015[3] under the mentorship of noted electrochemist Allen J. Bard, working on electrochemical energy storage and nanoscale electrocatalysis using scanning electrochemical microscopy. He then completed postdoctoral training at the University of California, Santa Barbara in the laboratory of Kevin W. Plaxco,[4] where he contributed to the development of the first in vivo continuous molecular monitoring platforms based on aptamer‑based sensing. [5][6]
Career
Netz began his independent career at the Johns Hopkins University School of Medicine, joining the Department of Pharmacology and Molecular Sciences as an Assistant Professor in 2019 and later being promoted to Associate Professor in 2023. His research group there focused on real‑time biosensing and therapeutic monitoring, and included graduate students and postdoctoral fellows working across chemistry, engineering, and pharmacology.
In 2025, Netz moved his laboratory to the University of North Carolina at Chapel Hill, where he is currently an Associate Professor of Chemistry.[7] His research program develops biology‑inspired electrochemical sensors capable of real‑time, continuous detection of physiologically relevant molecules in vivo. His work integrates chemistry, biophysics, and engineering to design implantable sensors, understand small‑molecule recognition by nucleic‑acid receptors, and build personalized diagnostic platforms.
Research
Netz’s research spans several areas within analytical chemistry and bioengineering:[8]
- Electrochemical aptamer‑based (E‑AB) sensors, including platforms for drug monitoring,[5] feedback‑controlled drug delivery,[6][9][10][11]
- Microneedle‑based wearable sensors for real‑time measurement of therapeutic drugs and metabolites in interstitial fluid.[12][13]
- Stable electrode interfaces designed to withstand prolonged implantation in biological fluids and maintain high signal‑to‑noise performance.[14]
- Glucometer‑based immunoassays, including the development of fusion‑protein-enabled diagnostic platforms using over‑the‑counter glucose meters for antibody detection.[15][16][17]
- Continuous molecular monitoring in awake, behaving animals, contributing to foundational methods for real‑time pharmacokinetics and neurochemical tracking.[5][11]
His laboratory’s work addresses therapeutic transport, sensor stability, metabolite tracking, and real‑time health monitoring, with applications in personalized medicine and point‑of‑care diagnostics.
Awards and honors
- Named a “Rising Star in Sensing” by ACS Sensors (2020)[18]
- Recipient of the Start a SUD Startup Challenge Award from NIDA (2022)[19]
Professional service
Netz currently serves as the Interim Editor-in-Chief of the journal ECS Sensors Plus,[20] which was launched by The Electrochemical Society in 2022. Prior to this role, he served as Reviewer, Associate Editor, and Technical Editor in the Sensors Technical Interest Area of the ECS portfolio of journals.
External links
References
- ↑ 1.0 1.1 "Arroyo, Netz". UNC College of Arts and Sciences, Chemistry. Retrieved 2026-01-23.
- ↑ Park, Alice. "Researchers Are Working on a New Rapid COVID-19 Immunity Test". TIME. Archived from the original on 2024-12-26. Retrieved 2026-01-23.
- ↑ "Degrees and Dates of Attendance". utdirect.utexas.edu. Retrieved 2026-01-23.
- ↑ "Plaxco Lab". plaxco.chem.ucsb.edu. Retrieved 2026-01-23.
- ↑ 5.0 5.1 5.2 Arroyo-Currás, Netzahualcóyotl; Somerson, Jacob; Vieira, Philip A.; Ploense, Kyle L.; Kippin, Tod E.; Plaxco, Kevin W. (2017-01-24). "Real-time measurement of small molecules directly in awake, ambulatory animals". Proceedings of the National Academy of Sciences. 114 (4): 645–650. doi:10.1073/pnas.1613458114. PMC 5278471. PMID 28069939.
- ↑ 6.0 6.1 Arroyo-Currás, Netzahualcóyotl; Ortega, Gabriel; Copp, David A.; Ploense, Kyle L.; Plaxco, Zoe A.; Kippin, Tod E.; Hespanha, João P.; Plaxco, Kevin W. (2018-11-09). "High-Precision Control of Plasma Drug Levels Using Feedback-Controlled Dosing". ACS Pharmacology & Translational Science. 1 (2): 110–118. doi:10.1021/acsptsci.8b00033. PMC 7088981 Check
|pmc=value (help). PMID 32219207 Check|pmid=value (help). - ↑ "Approved Personnel Actions". Board of Trustees. Retrieved 2026-01-23.
- ↑ 8.0 8.1 "Netzahualcóyotl Arroyo-Currás". scholar.google.com. Retrieved 2026-01-23.
- ↑ Dauphin-Ducharme, Philippe; Yang, Kyungae; Arroyo-Currás, Netzahualcóyotl; Ploense, Kyle L.; Zhang, Yameng; Gerson, Julian; Kurnik, Martin; Kippin, Tod E.; Plaxco, Kevin W. (2019-10-25). "Electrochemical Aptamer-Based Sensors for Improved Therapeutic Drug Monitoring and High-Precision, Feedback-Controlled Drug Delivery". ACS Sensors. 4 (10): 2832–2837. doi:10.1021/acssensors.9b01616. PMC 6886665 Check
|pmc=value (help). PMID 31556293. - ↑ Scida, Karen; Ornelas-Gatdula, Elysse; DePasquale, Michael; Carr, Gregory V.; Arroyo-Currás, Netzahualcóyotl (2025-02-14). "Therapeutic Drug Distribution across the Mouse Brain Is Heterogeneous as Revealed by In Vivo, Spatially Resolved Aptamer-Based Sensing". ACS Pharmacology & Translational Science. 8 (2): 435–445. doi:10.1021/acsptsci.4c00579. PMC 11843511 Check
|pmc=value (help). PMID 39990862 Check|pmid=value (help). - ↑ 11.0 11.1 Li, Jing; Clark, Vincent; Yu, Chen-Hsu; Scida, Karen; Aller Pellitero, Miguel; Rivera, Rolando L. Albarracín; Zhong, Wenrui; Demek, Erin; Fountain, Jeffrey; Mahlum, J.d.; Haaland, Richard E.; Carr, Gregory V.; Sczepanski, Jonathan; Arroyo-Currás, Netzahualcóyotl (2025). "Monitoring HIV Antiretroviral Therapy via Aptamer-Based Measurements in Preclinical Animal Models, in Human Plasma". Advanced Sensor Research. 4 (3): 2400191. doi:10.1002/adsr.202400191. ISSN 2751-1219. PMC 12478587 Check
|pmc=value (help). PMID 41030381 Check|pmid=value (help). - ↑ Wu, Yao; Tehrani, Farshad; Teymourian, Hazhir; Mack, John; Shaver, Alexander; Reynoso, Maria; Kavner, Jonathan; Huang, Nickey; Furmidge, Allison; Duvvuri, Andrés; Nie, Yuhang; Laffel, Lori M.; Doyle, Francis J. III; Patti, Mary-Elizabeth; Dassau, Eyal (2022-06-14). "Microneedle Aptamer-Based Sensors for Continuous, Real-Time Therapeutic Drug Monitoring". Analytical Chemistry. 94 (23): 8335–8345. doi:10.1021/acs.analchem.2c00829. ISSN 0002-7863. PMC 9202557 Check
|pmc=value (help). PMID 35653647 Check|pmid=value (help). - ↑ Reynoso, Maria; Chang, An-Yi; Wu, Yao; Murray, Raygan; Suresh, Smrithi; Dugas, Yuma; Wang, Joseph; Arroyo-Currás, Netzahualcóyotl (2024-01-15). "3D-printed, aptamer-based microneedle sensor arrays using magnetic placement on live rats for pharmacokinetic measurements in interstitial fluid". Biosensors and Bioelectronics. 244: 115802. doi:10.1016/j.bios.2023.115802. ISSN 0956-5663.
- ↑ Clark, Vincent; Prasad, Aditi; Yuan, Yuchan; Demek, Erin; Guzman, Frederick; Garcia, Lukas A.; Lukeman, Philip S.; Powell-Gray, Bethany; Rodríguez-López, Joaquín; Arroyo-Currás, Netzahualcóyotl (2025-07-25). "Extending the Operational Lifespan of Nucleic Acid-Based Electrochemical Sensors via Protection against Hydrogen Peroxide and Oligonucleotide Displacement". ACS Sensors. 10 (7): 4945–4953. doi:10.1021/acssensors.5c00603. PMC 12306533 Check
|pmc=value (help). PMID 40560885 Check|pmid=value (help). - ↑ Leonard, Elissa K.; Aller Pellitero, Miguel; Juelg, Boris; Spangler, Jamie B.; Arroyo-Currás, Netzahualcóyotl (2022-06-29). "Antibody–Invertase Fusion Protein Enables Quantitative Detection of SARS-CoV-2 Antibodies Using Widely Available Glucometers". Journal of the American Chemical Society. 144 (25): 11226–11237. doi:10.1021/jacs.2c02537. ISSN 0002-7863. PMC 9199438 Check
|pmc=value (help). PMID 35675509 Check|pmid=value (help). - ↑ Park, Han-Sol; Yin, Anna; Barranta, Caelan; Lee, John S.; Caputo, Christopher A.; Sachithanandham, Jaiprasath; Li, Maggie; Yoon, Steve; Sitaras, Ioannis; Jedlicka, Anne; Eby, Yolanda; Ram, Malathi; Fernandez, Reinaldo E.; Baker, Owen R.; Shenoy, Aarthi G. (2024-03-14). "Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial". JCI Insight. 9 (8). doi:10.1172/jci.insight.178460. ISSN 2379-3708.
- ↑ Ornelas-Gatdula, Elysse; An, Xinran; Spangler, Jamie B.; Arroyo-Currás, Netzahualcóyotl (2026). "Adapting antibody–invertase fusion protein immunoassays to multiwell plates for infectious disease antibody quantification". Sensors & Diagnostics. 5 (1): 83–93. doi:10.1039/D5SD00117J. ISSN 2635-0998.
- ↑ "Rising Stars in Sensing". pubs.acs.org. Retrieved 2026-01-23.
- ↑ Abuse, National Institute on Drug (2022-01-10). "2021 "$100,000 for Start a SUD Startup" Challenge | National Institute on Drug Abuse (NIDA)". nida.nih.gov. Retrieved 2026-01-23.
- ↑ "ECS Sensors Plus". ECS. Retrieved 2026-01-23.
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