Oded Rechavi
| Oded Rechavi | |
|---|---|
| Born | Israel |
| 🏳️ Nationality | Israeli |
| 🎓 Alma mater | Tel Aviv University |
| 💼 Occupation | |
| Known for | Transgenerational epigenetic inheritance, Ancient DNA analysis |
| 🏅 Awards | Kadar Family Award, Blavatnik Award, Schmidt Science Polymath |
Oded Rechavi is an Israeli neuroscientist and geneticist who serves as a professor at Tel Aviv University. He has worked on epigenetic inheritance, particularly the transgenerational transmission of acquired traits via small RNA (ribonucleic acid) molecules in nematodes. Rechavi's interdisciplinary work spans genetics, neurobiology, and ancient DNA analysis.
Education and career
Rechavi earned his Ph.D. in neurobiology from Tel Aviv University. He completed his postdoctoral research under Oliver Hobert at Columbia University, where he provided evidence that traits can be inherited through small RNA molecules.[1] In 2012, he established his laboratory at Tel Aviv University, focusing on challenging established dogmas in inheritance and evolution using model organisms such as Caenorhabditis elegans.[2][3]
Research contributions
Rechavi's research has indicated that environmental challenges can induce the synthesis of heritable small RNAs in nematodes, leading to phenotypic changes in subsequent generations.[4] His work has explained mechanisms governing the duration and specificity of transgenerational small RNA inheritance.[5]
His lab has also explored the neuronal basis of decision-making and irrationality in C. elegans using neural circuit models and behavior assays.[5] In another line of work, Rechavi's team developed genetically engineered parasites capable of delivering therapeutic proteins to the nervous system.[6]
In an interdisciplinary project, Rechavi collaborated with biblical scholars to analyze ancient DNA from the Dead Sea Scrolls’ parchment, helping to clarify their geographical origins and editorial history.[7][8]
Science communication and outreach
In 2020, Rechavi organized "Woodstock.bio," a first-of-its-kind biology conference inspired by interactions on Twitter. The event featured over 70 speakers, including keynotes by Nobel laureate Dan Shechtman, Prof. Piali Sengupta, and Prof. Uri Alon. Presentations were limited to one slide, and the order of speakers was randomized to foster spontaneity.[9][10][11]
Awards and honors
- 2019 – Kadar Family Award for Outstanding Research at Tel Aviv University
- 2018 – Blavatnik Award for Young Scientists in Israel
- 2020 – Schmidt Science Polymath Award, providing $2.5 million for unrestricted research
- European Research Council (ERC) Fellow
- Recipient of the Krill Prize of the Wolf Foundation, Alon Fellowship, F.I.R.S.T (Bikura) Prize, and Gruss Lipper Postdoctoral Fellowship
Selected publications
- Rechavi, O. (2020). Transgenerational Inheritance: That Pathogen Gut Feeling. Current Biology, 30(24), R1486–R1488.[12]
- Houri-Ze’evi, L., Antonova, O., & Rechavi, O. (2020). Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans. Cell, 182(5), 1186–1197.e12.[13]
- Anava, S., Neuhof, M., Gingold, H., et al. (2020). Illuminating Genetic Mysteries of the Dead Sea Scrolls. Cell, 181(6), 1248–1259.e15.[14]
- Cohen, D., Teichman, G., Volovich, M., et al. (2019). Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways. Nature Communications, 10, 3692.[15]
References
- ↑ Rechavi, Oded; Minevich, Gregory; Hobert, Oliver (2011-12-09). "Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans". Cell. 147 (6): 1248–1256. doi:10.1016/j.cell.2011.10.042. ISSN 0092-8674. PMC 3250924. PMID 22119442.
- ↑ "The Oded Rechavi Lab". Oded Rechavi Lab. Retrieved 2025-04-24.
- ↑ "Oded Rechavi, Ph.D." Allen Discovery Center at Tufts University. Retrieved 2025-04-24.
- ↑ "Epigenetic Memories Are Passed Down in Worm Sperm". Wired. 2022-02-16. Retrieved 2024-04-21.
- ↑ 5.0 5.1 "Oded Rechavi: "Do things in your own style"". eLife. 2022. Retrieved 2024-04-21.
- ↑ "From Lab to Likes: Socializing Science Through Humor". The Scientist. 2023-03-01. Retrieved 2024-04-21.
- ↑ "Ancient DNA offers clues to the physical origins of the Dead Sea Scrolls". National Geographic. 2020-06-02. Retrieved 2024-04-21.
- ↑ "Ancient DNA Yields New Clues to Dead Sea Scrolls". Scientific American. 2020-06-02. Retrieved 2024-04-21.
- ↑ "TAU's first-of-its-kind "Twitter conference"". Tel Aviv University. 2020-02-07.
- ↑ "February 2020: Woodstock.bio: Sci-twitter-inspired biology conference". Edmond J. Safra Center for Bioinformatics.
- ↑ Glausiusz, Josie (December 18, 2019). "From social media to conference social". Nature. Retrieved April 25, 2025.
- ↑ Rechavi, Oded (2020-12-21). "Transgenerational Inheritance: That Pathogen Gut Feeling". Current Biology. 30 (24): R1486–R1488. Bibcode:2020CBio...30R1486R. doi:10.1016/j.cub.2020.10.088. ISSN 0092-8674. PMID 33352132 Check
|pmid=value (help). - ↑ Houri-Zeevi, Leah; Kohanim, Yael Korem; Antonova, Olga; Rechavi, Oded (2020-09-03). "Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans". Cell. 182 (5): 1186–1197.e12. doi:10.1016/j.cell.2020.07.022. ISSN 0092-8674. PMC 7479518 Check
|pmc=value (help). PMID 32841602 Check|pmid=value (help). - ↑ Anava, Sarit; Neuhof, Moran; Gingold, Hila; Sagy, Or; Munters, Arielle; Svensson, Emma M.; Afshinnekoo, Ebrahim; Danko, David; Foox, Jonathan; Shor, Pnina; Riestra, Beatriz; Huchon, Dorothée; Mason, Christopher E.; Mizrahi, Noam; Jakobsson, Mattias (2020-06-11). "Illuminating Genetic Mysteries of the Dead Sea Scrolls". Cell. 181 (6): 1218–1231.e27. doi:10.1016/j.cell.2020.04.046. ISSN 0092-8674. PMID 32492404 Check
|pmid=value (help). - ↑ Cohen, Dror; Teichman, Guy; Volovich, Meshi; Zeevi, Yoav; Elbaum, Lilach; Madar, Asaf; Louie, Kenway; Levy, Dino J.; Rechavi, Oded (2019-08-13). "Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways". Nature Communications. 10 (1): 3692. Bibcode:2019NatCo..10.3692C. doi:10.1038/s41467-019-11715-7. ISSN 2041-1723. PMC 6692327 Check
|pmc=value (help). PMID 31409788.
External links
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