Ovarian Rejuvenation
Ovarian Rejuvenation
Ovarian rejuvenation is an experimental fertility treatment that uses either the patient's own Platelet-rich plasma[1][2] (PRP) or Stem-cell therapy such as Adipose-Derived Stem Cells (ADSCs)[3][4] to improve ovarian function and to improve oocyte (egg) quality and/or quantity. The procedure involves injecting the PRP or stem cells into the ovaries to encourage the development of new and healthier eggs, potentially increasing the chances of conception either naturally or via Assisted reproductive technology.
It is used for women with low or diminished ovarian reserve, which typically declines with age or in conditions like Primary ovarian insufficiency.
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- ↑ Éliás, M.; Kónya, M.; Kekk, Z.; Turan, C.; das Virgens IPA; Tóth, R.; Keszthelyi, M.; Hegyi, P.; Várbíró, S.; Sipos, M. (2024). "Platelet-rich plasma (PRP) treatment of the ovaries significantly improves fertility parameters and reproductive outcomes in diminished ovarian reserve patients: a systematic review and meta-analysis". J Ovarian Res. 17 (1): 104. doi:10.1186/s13048-024-01423-2. PMC 11100055 Check
|pmc=value (help). PMID 38760869 Check|pmid=value (help). - ↑ Seckin, S.; Ramadan, H.; Mouanness, M.; Kohansieh, M.; Merhi, Z. (2022). "Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action". J Assist Reprod Genet. 39 (1): 37–61. doi:10.1007/s10815-021-02385-w. PMC 8866624 Check
|pmc=value (help). PMID 35175511 Check|pmid=value (help). - ↑ Mashayekhi, M.; Mirzadeh, E.; Chekini, Z.; Ahmadi, F.; Eftekhari-Yazdi, P.; Vesali, S.; Madani, T.; Aghdami, N. (2021). "Evaluation of safety, feasibility and efficacy of intra-ovarian transplantation of autologous adipose derived mesenchymal stromal cells in idiopathic premature ovarian failure patients: non-randomized clinical trial, phase I, first in human". J Ovarian Res. 14 (1): 5. doi:10.1186/s13048-020-00743-3. PMC 7786909 Check
|pmc=value (help). PMID 33407794 Check|pmid=value (help). - ↑ Ai, G.; Meng, M.; Guo, J.; Li, C.; Zhu, J.; Liu, L.; Liu, B.; Yang, W.; Shao, X.; Cheng, Z.; Wang, L. (2023). "Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence". Stem Cell Res Ther. 14 (1): 75. doi:10.1186/s13287-023-03297-5. PMC 10088140 Check
|pmc=value (help). PMID 37038203 Check|pmid=value (help).
