Ozonized Glycerin
Overview
Ozonized glycerin (also known as ozonated glycerin) is a compound obtained by the reaction of glycerin with ozone. The oxidation of glycerin by ozone is resulting in the formation of ozonized compounds within the glycerin molecule. It is used in medical and cosmetic applications due to its antimicrobial, anti-inflammatory, and wound-healing properties. [1]
History
The use of ozonized glycerin in medicine can be traced back to the early 20th century. Around 1900, American chemist Charles Marchand published a book describing the medicinal applications of a compound known as Glycozone, which was essentially ozonized glycerin. At the time, it was marketed as a disinfectant and internal remedy. Despite this early interest, the use of ozonized glycerin gradually faded from medical practice, likely due to evolving pharmaceutical standards and limited understanding of ozone chemistry at the time. For over a century, the compound remained largely forgotten until it was re-examined and technologically refined in the early 2000s. The original publication by Marchand has since been reissued and is now publicly available, offering historical insight into the early experimentation with ozone-based therapeutics.
Development and Background
Ozonized glycerin is based on a patented technology developed in 2001 by VMC (now Mediplus Pharma), a company established in 1973 in Japan. [2] This invention was inspired by the need to address challenges in the medical field.
Origins and Inspiration
Initially, ozonized water was used in medical settings and was used in medical settings to prevent skin irritation caused by frequent handwashing while also to promote skin regeneration. This led to further exploration of ozone’s potential in medical applications for a more stable form for practical use.
Technical Challenges
Ozone is highly unstable and decomposes rapidly, making its stable utilization a technical challenge. Additionally, its strong characteristic odor posed another issue for widespread use.
Solutions and Applications
VMC (now Mediplus Pharma) developed a process for the reaction of plant-derived glycerin with ozone. This process successfully stabilized the effects of ozone and eliminated its odor, leading to the registration of a patent (No. 7534001). [3] The following effects have been confirmed through this technology:
- Antimicrobial and bactericidal effects [4] [5] [6]
- Promotion of wound healing [7]
- Stimulation of cell proliferation [8] [9]
- Enhancement of collagen synthesis [8]
- Moisturizing and skin-brightening effects [1]
Initially, products using this technology were stable for up to three months at room temperature and approximately one year when frozen. However, further research was required to ensure stability at room temperature, and in 2022, a stable formulation was successfully developed.
Safety
Ozonized glycerin’s safety has been confirmed primarily for external use on the skin and oral applications. ________________________________________ [10] [11]
References
- ↑ 1.0 1.1 Keigo Hanada; Daiki Okuda; Ryuhei Ogi (June 2022). "Ozonized glycerin (OG)-based cosmetic products lighten age spots on human facial skin". Journal of Cosmetic Dermatology. 2; 21 (7): 3133–3139. doi:10.1111/jocd.15002. PMC 9544616 Check
|pmc=value (help). PMID 35435300 Check|pmid=value (help). - ↑ オゾン溶存グリセリン溶液の製造方法(特許第4677192号)
- ↑ オゾン処置グリセリン、オゾン処理グリセリンの製造方法、化粧料、飲食品、及び口腔用組成物 (特許第7575652号)
- ↑ Gotaro Shiota; Kikumi Suzuki; Seiji Yagi (2004). "オゾンジヱルの基礎的検討⑴一持続性オゾンジヱルの殺菌効果一". 日本褥瘡学会誌 (in 日本語). 5: 312.
- ↑ 新實 一仁; 金石 あずさ; Akihiko Shiba (2004). "オゾンジェルの殺菌効果について". 昭和歯学会雑誌. 24 (2): 103–109.
- ↑ Tatsuya Fukui; Kazuya Masuno; Yoshimasa Makita (2014). "歯周細菌に対するオゾンゲルの抗微生物作用 Antimicrobial Effects of Ozone Gel Against Periodontal Bacteria". Journal of Hard Tissue Biology. 23: 445–448. doi:10.2485/jhtb.23.445.
- ↑ 栗原 規剛 (2006). "オゾン軟膏塗布による創傷治癒の病理組織学的研究". 昭和歯学会雑誌. 26 (4): 338–347.
- ↑ 8.0 8.1 Wang Pao-Li; Yoichi Tachi; Kazuya Masuno (2018). "オゾンジェルがヒト骨肉腫細胞株Saos-2による骨基質産生に与える影響 The Effect of Ozone Gel on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2". Journal of Hard Tissue Biology. 27: 195–198. doi:10.2485/jhtb.27.195.
- ↑ Nobutaka Okusa; Hourei Oh; Kazuya Masuno (2023). "Comparative Study of Ozonated Glycerol and Macrogol Ointment on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2". Materials. 16 (10): 3857. Bibcode:2023Mate...16.3857O. doi:10.3390/ma16103857. PMC 10220665 Check
|pmc=value (help). PMID 37241484 Check|pmid=value (help). - ↑ Pao-Li Wang; Gotaro Shiota; Akihiko Shiba (2011). "Safety Evaluation of Ozone Gel for Skin and Eye on Animal Experiments". Journal of Hard Tissue Biology. 20 (4): 313–318. doi:10.2485/jhtb.20.313.
- ↑ Tatsuya Fukui; Kazuya Masuno; Yoshimasa Makita (2015). "Evaluation of Oral Mucosa Irritation produced by Ozone Gel". Journal of Hard Tissue Biology. 24 (1): 104–106. doi:10.2485/jhtb.24.104.
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