Paul Kubes
| Paul Kubes | |
|---|---|
| Born | April 23, 1962 Czechoslovakia |
| 🏡 Residence | Calgary, Alberta, Canada |
| 🏳️ Citizenship | Canadian |
| 🎓 Alma mater | Queen's University, Ontario, Canada |
| 💼 Occupation | |
| Known for | Use of inhaled nitric oxide as a potential therapy for excessive inflammation, live imaging of leukocyte recruitment during various pathological conditions |
| 🏅 Awards | Henry Friesen Award 2010,
Canada's health researcher of the year 2011, Hardy Cinder Award 2012, |
Paul Kubes (born April 23, 1962) is a Canadian immunologist specializing in visualizing the role of immune cells such as neutrophils, monocytes, NKT cells and Kupffer cells during infection and inflammation.[1] He is a Professor at the University of Calgary’s Faculty of Medicine and the Founding Director of the Snyder Institute for Chronic Disease[2]. He was named Canada’s Health Researcher of the Year by the Canadian Institutes of Health Research (CIHR) in 2011 for his work on how the brain affects immunity.
Education
Kubes received his college degree in 1981 from John Abbott College, Quebec, Canada in Health Science and his BScHons, MSc and PhD degrees from Queen's University, Ontario, Canada. He completed his BScHons in 1984 under the guidance of P. Johansen. Then, under the supervision of Chris Chapler, he completed his MSc in 1986 and PhD degree in 1988 in the area of Cardiovascular Physiology.
Career and Research
After his Ph.D., he went on to work with Neil Granger at Louisiana State University (Medical Center) on a post-doctoral fellowship in 1988. His research involved studying the excessive inflammation associated with heart attacks and strokes. He developed a system to visualize the behaviour of leukocytes in blood vessels under normal conditions and heart conditions like an ischemic episode in the heart. He returned to Canada in 1991 as Assistant Professor at the University of Calgary. Here he continued to study the mechanisms that lead to recruitment of leukocytes in cardiovascular diseases. Kubes and his team identified that an endogenously produced gas, nitric oxide, functions to reduce leukocyte recruitment and that inhaled NO can be used as a potential therapy for excessive inflammation during ischemia[3]. Since then he has branched his field of research to understand leukocyte recruitment in various models of inflammatory disease in various tissues including the brain[4], liver[5] and the gut[6]. He currently holds a full Professor position at the University of Calgary’s Faculty of Medicine, Department of Physiology and Pharmacology. The current primary focus of his lab is to directly visualize the roles of immune cells such as platelets, neutrophils and neutrophil extracellular traps(NETs)[7] during inflammation, infection and sepsis and tissue injury using cutting edge technology, including spinning-disk confocal, resonant-scanning confocal, and multi-photon microscopy[8].
In 2008, Kubes was involved in the founding of the Snyder Institute for Chronic Diseases and has been the founding director of the institute since then. He holds a Canada Research Chair in Leukocyte Recruitment in Inflammatory Disease[9]. He is appointed as the Snyder Research Chair in Critical Care Medicine. He operates a translational laboratory that supports critical care clinical trials with molecular lab tests. Kubes runs a training program geared towards elucidating the cellular, molecular, and physiologic mechanisms of infectious and immune disease and a clinical program entitled the AHFMR Alberta Sepsis Network[10]. Any patient that enters an Alberta ICU enters this program.
Kubes presently holds twelve peer-reviewed grants, six of which are CIHR grants. He has published over 300 peer-reviewed papers in high impact science journals including Cell, Science and Nature Medicine as well as clinical journals like Lancet.
Prominent Awards
2019 Gabor Kaley Memorial Lectureship
2018 Killam Annual Professor Award
2018 Smith Faculty Award
2016 Seymour Heisler Memorial Lectureship Award
2015 Chair Gairdner Award MAB committees, Member F1000
2012 CSI Cinader Award/Lecture[11]
2011 CIHR Researcher of the Year
2011 CAG Research Excellence Award Lecturer
2010 Canadian Society Clinical Investigation (CSCI)/Royal College Physicians Surgeons Canada (RCPSC) Henry Friesen Award
2010 Canadian Society of Immunology Investigator Award
2009 Distinguished Scholar Award, Royal Society of Canada
2005 Alberta Science and Technology Award[12]
2003 Faculty of Medicine Smith Distinguished Achievement Award
2003 American Physiological Society, Henry Pickering Bowditch Lectureship
2002 Viventia Biotech Distinguished Professor of Immunology Lectureship
2001 Faculty of Medicine’s Smith Distinguished Achievement Award
Recent research contributions
- Liew PX, Kubes P. The Neutrophil's Role During Health and Disease. *Physiol Rev*. 2019 Apr 1;99(2):1223-1248. doi: 10.1152/physrev.00012.2018
- Zeng Z, Surewaard BGJ, Wong CHY, Guettler C, Petri B, Burkhard R, Wyss M, Le Moual H, Devinney R, Thompson GC, Blackwood J, Joffe AR, McCoy KD, Jenne CN, Kubes P. Sex-hormone-driven innate antibodies protect females and infants against EPEC infection. *Nat Immunol*. 2018 Oct;19(10):1100-1111. doi: 10.1038/s41590-018-0211-2. Epub 2018 Sep 24.
- Bogoslowski A, Butcher EC, Kubes P. Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminating Staphylococcus aureus. *Proc Natl Acad Sci U S A*. 2018 Mar 6;115(10):2449-2454. doi: 10.1073/pnas.1715756115. Epub 2018 Jan 29.
- Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P. Visualizing the function and fate of neutrophils in sterile injury and repair. *Science*. 2017 Oct 6;358(6359):111-116. doi: 10.1126/science.aam9690.
- Wang J, Kubes P. A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair. *Cell*. 2016 Apr 21;165(3):668-78. link
Personal life
Born in Czechoslovakia, Kubes came with his family to Canada after escaping from Russian invasion in 1968. After immigrating to Canada, his father George Kubes worked at McGill as a professor in Chemical Engineering and his mother Milena was a psychologist.
References
- ↑ "Paul Kubes Research Lab".
- ↑ "Synder Institute for Chronic diseases".
- ↑ Fox-Robichaud, A; Payne, D; Hasan, S U; Ostrovsky, L; Fairhead, T; Reinhardt, P; Kubes, P (1998-06-01). "Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds". Journal of Clinical Investigation. 101 (11): 2497–2505. doi:10.1172/jci2736. ISSN 0021-9738. PMC 508839. PMID 9616221.
- ↑ "The Hotchkiss Brain Institute".
- ↑ Wang, Jing; Kubes, Paul (April 2016). "A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair". Cell. 165 (3): 668–678. doi:10.1016/j.cell.2016.03.009. ISSN 0092-8674. PMID 27062926.
- ↑ "Calgary diseases expert on the importance of studying our guts". Retrieved 2019-03-26.
- ↑ McDonald, Braedon; Urrutia, Rossana; Yipp, Bryan G.; Jenne, Craig N.; Kubes, Paul (September 2012). "Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis". Cell Host & Microbe. 12 (3): 324–333. doi:10.1016/j.chom.2012.06.011. ISSN 1931-3128. PMID 22980329.
- ↑ Scott, Brittney N. V.; Sarkar, Tina; Kratofil, Rachel M.; Kubes, Paul; Thanabalasuriar, Ajitha (2019-02-18). "Unraveling the host's immune response to infection: Seeing is believing". Journal of Leukocyte Biology. doi:10.1002/JLB.4RI1218-503R. ISSN 1938-3673. PMID 30776153.
- ↑ Government of Canada, Industry Canada (2012-11-29). "Canada Research Chairs". www.chairs-chaires.gc.ca. Retrieved 2019-03-26.
- ↑ Services, Alberta Health. "Research". Alberta Health Services. Retrieved 2019-03-26.
- ↑ "Canadian Society of Immunologists Awards" (PDF).
- ↑ "Kubes, Paul – ASTech Foundation". Retrieved 2019-03-26.
External Sites
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