Philip J. Gerrish
| Philip J. Gerrish | |
|---|---|
| File:Headshot0.pngHeadshot0.png Gerrish in 2026 | |
| Born | Burlington, Vermont, U.S. |
| 🎓 Alma mater | Hope College; Michigan State University |
| 💼 Occupation | |
| Known for | Mathematical theory of clonal interference |
Philip J. Gerrish is an American evolutionary biologist whose work uses mathematical and experimental approaches to study adaptation in microbial and viral populations. He is known for work with Richard Lenski on clonal interference, the competition among independently arising beneficial mutations in asexual populations. A later review described their 1998 paper as the first systematic statistical treatment of the phenomenon.[1]
Early life and education
Gerrish was born in Burlington, Vermont. Three weeks after his birth, his family moved to Nigeria. He spent much of his primary-school education in Michigan before moving to Malawi, where he attended St Andrew's school in Blantyre, and later returned to Michigan to finish high school.[citation needed]
At Hope College, Gerrish studied physics and philosophy, receiving bachelor's degrees in both subjects in 1988.[citation needed] He then lived for four years in Honduras, where he taught physics and philosophy at a college-preparatory school and violin and viola in the music department of the National Autonomous University of Honduras.[citation needed]
Gerrish earned a master's degree in biosystems engineering from Michigan State University in 1994 and a doctorate in zoology there in 1998. His doctoral research, supervised by Richard Lenski, focused on population genetics and microbial evolution.[citation needed]
Career and research
Gerrish held postdoctoral appointments at the Centers for Disease Control and Prevention and Los Alamos National Laboratory. He later worked at the Santa Fe Institute, the Instituto Gulbenkian de Ciência, the University of New Mexico, and the Georgia Institute of Technology. The University of New Mexico has listed him as a research associate professor of biology.[2] Los Alamos National Laboratory maintains an institutional record of his publications.[3]
Clonal interference and adaptation
In 1998, Gerrish and Lenski developed a model for the fate of competing beneficial mutations in asexual populations.[4] The model quantified how a beneficial mutation that would otherwise spread can be displaced by a fitter mutation arising in another lineage. Subsequent theoretical and experimental work adopted this framework to study the rate and genetic composition of adaptation in large microbial populations.[1][5]
Gerrish has also studied the evolution of mutation rates and the circumstances under which excessive mutation can impede adaptation or weaken natural selection.[6] His other research has addressed mutation-rate estimation,[7] evolutionary forecasting,[8] and applications of evolutionary theory to infectious disease and cancer.[9]
Music
Music has been a continuing part of Gerrish's life alongside his scientific career. A violinist and violist, he has performed with orchestras and chamber ensembles in Michigan, Honduras, Georgia, and New Mexico, and has taught string players in institutional and volunteer programs.[citation needed]
Selected publications
- Gerrish, Philip J.; Lenski, Richard E. (1998). "The fate of competing beneficial mutations in an asexual population". Genetica. 102–103: 127–144. doi:10.1023/A:1017067816551.
- Sniegowski, Paul D.; Gerrish, Philip J.; Lenski, Richard E. (1997). "Evolution of high mutation rates in experimental populations of E. coli". Nature. 387: 703–705. doi:10.1038/42701.
- de Visser, J. Arjan G. M.; Zeyl, Clifford W.; Gerrish, Philip J.; Blanchard, Jeffrey L.; Lenski, Richard E. (1999). "Diminishing returns from mutation supply rate in asexual populations". Science. 283 (5400): 404–406. doi:10.1126/science.283.5400.404.
- Gerrish, Philip J.; Colato, Alexandre; Perelson, Alan S.; Sniegowski, Paul D. (2007). "Complete genetic linkage can subvert natural selection". Proceedings of the National Academy of Sciences. 104 (15): 6266–6271. doi:10.1073/pnas.0607280104.
References
- ↑ 1.0 1.1 Park, Su-Chan; Krug, Joachim (2007). "Clonal interference in large populations". Proceedings of the National Academy of Sciences. 104 (46): 18135–18140. doi:10.1073/pnas.0705778104. PMC 2084291. PMID 17989231.
- ↑ "Philip Gerrish, PhD". Center for Evolutionary and Theoretical Immunology. University of New Mexico. Retrieved 16 July 2026.
- ↑ "Philip John Gerrish". Los Alamos Research Online. Los Alamos National Laboratory. Retrieved 16 July 2026.
- ↑ Gerrish, Philip J.; Lenski, Richard E. (1998). "The fate of competing beneficial mutations in an asexual population". Genetica. 102–103: 127–144. doi:10.1023/A:1017067816551. PMID 9720276.
- ↑ Maddamsetti, Rohan; Lenski, Richard E.; Barrick, Jeffrey E. (2015). "Adaptation, clonal interference, and frequency-dependent interactions in a long-term evolution experiment with Escherichia coli". Genetics. 200 (2): 619–631. doi:10.1534/genetics.115.176677. PMC 4492384. PMID 25911659.
- ↑ Gerrish, Philip J.; Colato, Alexandre; Sniegowski, Paul D. (2013). "Genomic mutation rates that neutralize adaptive evolution and natural selection". Journal of the Royal Society Interface. 10 (85): 20130329. doi:10.1098/rsif.2013.0329. PMC 4043158. PMID 23720539.
- ↑ Gerrish, Philip J. (2008). "A simple formula for obtaining markedly improved mutation rate estimates". Genetics. 180 (3): 1773–1778. doi:10.1534/genetics.108.091777. PMC 2581948. PMID 18791260.
- ↑ Gerrish, Philip J.; Sniegowski, Paul D. (2012). "Real time forecasting of near-future evolution". Journal of the Royal Society Interface. 9 (74): 2268–2278. doi:10.1098/rsif.2012.0119. PMC 3405750. PMID 22513783.
- ↑ Sprouffske, Kathleen; Merlo, Lauren M. F.; Gerrish, Philip J.; Maley, Carlo C.; Sniegowski, Paul D. (2012). "Cancer in light of experimental evolution". Current Biology. 22 (17): R762–R771. doi:10.1016/j.cub.2012.06.065. PMC 3457634. PMID 22975016.
External links
Category:Living people Category:American evolutionary biologists Category:American population geneticists Category:Mathematical biologists Category:Hope College alumni Category:Michigan State University alumni
This article "Philip J Gerrish" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Philip J Gerrish. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
