Protein AF
Protein Antisecretory Factor (AF) is multifunctional and facilitates clinical protection against different types of pathological secretion states and inflammation[1][2][3][4]. Mapping the effects of Protein AF in vivo and in vitro has been ongoing since early in the 1980's, and its cDNA has been cloned and sequenced. The antisecretory and anti-inflammatory activity is localized in the amino-terminal part of the 41 kD large AF-Protein, and is exerted by a variety of peptide sequences[5]. Protein AF is part of the innate immune system. Protein AF has been found in all examined tissue, and the protein excretes in blood, bile, breast milk, faces, liqvor, saliva, and tear fluid. The endogenous production of Protein AF is stimulated, for instance, by bacterial toxins, but it can also be stimulated in both people and animals by intake of special foods.
The effects of Protein AF in vivo has been mapped out in mice, rats, pigs, and humans. The development of Protein AF-stimulated pig feed was initiated in 1986 when Sweden prohibited the addition of antibiotics in feeds. The research resulted in the possibility of replacing antibiotic-stimulated feeds with Protein AF-stimulated feeds. These feeds gave equal or better production results than antibiotic-stimulated feeds, while also eliminated the risk of developing a bacterial resistance.
Protein AF-stimulated foods for humans has, through clinical studies, led to significant improvements when suffering from diseases such as inflammatory bowel diseases[6][7][8], diarrhea in relation to carcinoid tumors[9], Menieres disease[10], diarrhea in children[11], and mastitis[12]. Inflammatory reactions and secretory disorders are the most important common denominators for all mentioned diseases. It is also on these clinical variables that Protein AF has its effect.
Further research on Protein AF is largely supported by Lantmännen, who has concentrated Protein AF in two consumer products (SPC-Flakes and Salovum) which can be found in pharmacies in Sweden and another ten countries.
References[edit]
- ↑ Johansson E, Lonnroth I, Lange S, Jonson I, Jennische E, Lonnroth C. Molecular-Cloning and Expression of a Pituitary-Gland Protein Modulating Intestinal Fluid Secretion. Journal of Biological Chemistry. 1995; 270:20615-20
- ↑ Lange S, Lonnroth I. The antisecretory factor: synthesis, anatomical and cellular distribution, and biological action in experimental and clinical studies. International Review of Cytology. 2001; 210:39-75
- ↑ Zaman S, Aamir K, Hanson LA, Lange S. High doses of Antisecretory Factor stop diarrhea fast without recurrence for six weeks post treatment. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2018; 71:48-52
- ↑ Gustafsson AM, Fransson E, Dubicke A, Hjelmstedt AK, Ekman-Ordeberg G, Silfverdal SA, et al. Low levels of anti-secretory factor in placenta are associated with preterm birth and inflammation. Acta obstetricia et gynecologica Scandinavica. 2018; 97:349-56
- ↑ Johansson E, Lange S, Lonnroth I. Identification of an active site in the antisecretory factor protein. Biochimica et biophysica acta. 1997; 1362:177-82
- ↑ Bjorck S, Bosaeus I, Ek E, Jennische E, Lonnroth I, Johansson E, et al. Food induced stimulation of the antisecretory factor can improve symptoms in human inflammatory bowel disease: a study of a concept. Gut. 2000; 46:824-9
- ↑ Eriksson A, Shafazand M, Jennische E, Lonnroth I, Lange S. Antisecretory factor-induced regression of Crohn's disease in a weak responder to conventional pharmacological treatment. Inflammatory bowel diseases. 2003; 9:398-400
- ↑ Eriksson A, Shafazand M, Jennische E, Lange S. Effect of antisecretory factor in ulcerative colitis on histological and laborative outcome: a short period clinical trial. Scandinavian journal of gastroenterology. 2003; 38:1045-9
- ↑ Laurenius A, Wangberg B, Lange S, Jennische E, Lundgren BK, Bosaeus I. Antisecretory factor counteracts secretory diarrhoea of endocrine origin. Clinical nutrition. 2003; 22:549-52
- ↑ Hanner P, Rask-Andersen H, Lange S, Jennische E. Antisecretory factor-inducing therapy improves the clinical outcome in patients with meniere's disease. Acta oto-laryngologica. 2010; 130:223-7
- ↑ Zaman S, Aamir K, Hanson LA, Lange S. High doses of Antisecretory Factor stop diarrhea fast without recurrence for six weeks post treatment. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2018; 71:48-52
- ↑ Svensson K, Lange S, Lonnroth I, Widstrom AM, Hanson LA. Induction of anti-secretory factor in human milk may prevent mastitis. Acta paediatrica. 2004; 93:1228-31
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