Reesha Patel
| Reesha Patel | |
|---|---|
| Born | |
| 🎓 Alma mater | Indiana University Indiana University School of Medicine |
| 💼 Occupation | |
| 🌐 Website | https://reeshapatellab.org/ |
Reesha Patel is a scientist researching the neurological mechanics of alcoholism at the Northwestern University Feinberg School of Medicine. After completing a postdoctoral fellowship at the Northwestern University Salk Institute, she will assume the role of Assistant Professor in January 2023. Her primary interests are the effect of alcohol use on the amygdala, and the association between social stress and alcohol addiction [1].
Education and early career
In 2016, Patel received a BS in Neuroscience from Indiana University. She went on to graduate studies at the university’s school of medicine, where she earned her PhD in Medical Neuroscience [1]. Her doctoral advisor was Theodore R. Cummins, an investigator of ion channel biology [2]. Patel’s doctoral research focused on the Nav1.1 and Nav1.6 subtypes of voltage-gated sodium channels, mutations of which are associated with rare, difficult-to-treat epileptic syndromes [3]. She found that mutations in the genes responsible for Nav1.6 receptors slowed inactivation following action potentials, leading to resurgent electrical current in the affected neurons. Importantly, she was able to pharmacologically inhibit Nav1.6 mutated receptors, which decreased excitability [3]. Her findings provided critical insights into developing new treatments for epilepsies. Patel completed a postdoctoral fellowship at the Scripps Research Institute in the Marisa Roberto Lab [1]. There, she began studying the effects of alcohol-use disorder on the amygdala. For example, she studied the differences in interleukin expression due to chronic alcohol intoxication. She found that interleukin-1β is more highly expressed in alcohol-dependent mice, and that its expression regulated neuronal GABA transmission [4].
Current research
In 2019, Dr. Patel began a postdoctoral fellowship under the mentorship of Dr. Kay Tye at the Salk Institute for Biological Studies [1]. Much of her research there has involved studying different neural and glial populations in the amygdala, and how they are affected by alcohol consumption. She continued to study interleukin expression, such as her recent work on the effects of interleukin IL-1R and IL-10 systems on GABA transmission in the amygdala. In 2021, Patel published a paper indicating that overexpression of IL-10 helped decrease escalation of alcohol consumption by normalizing GABA transmission in the amygdala [5]. This finding points to possible new treatment options for alcohol use disorder. In 2023, Dr. Patel will start her role as an assistant professor at Northwestern University Feinberg School of Medicine. She has also become principal investigator of her own lab, and is continuing to explore her research interests. Since her last fellowship, she has studied the effects of corticotropin releasing factors, and the neurons that express CRF receptors. In 2022, she published results showing that prefrontal CRF-1 neurons regulate anxiety and reward during alcohol withdrawal [6]. Additionally, she is starting a project on the neuroimmune effects of social stress-induced alcohol dependence, for which she has received funding from the NIH [7]. She also received two previous funding awards from the NIH in 2017 and 2018 for her postdoctoral work in the Roberto lab [1].
Awards and honors
- 2021 Early Career Investigator Winner of the NIDA-NIAAA Frontiers in Addiction Research
- 2021 Research Society on Alcoholism: Enoch Gordis Award Winner
- 2020 Salk Institute for Biological Sciences – Society of Research Fellows Travel Award
- 2019 Research Society on Alcoholism: AARIO Young Investigator Award
Select publications
- Patel, R. R., Wolfe, S. A., Borgonetti, V., Gandhi, P. J., Rodriguez, L., Snyder, A. E., D'Ambrosio, S., Bajo, M., Domissy, A., Head, S., Contet, C., Dayne Mayfield, R., Roberts, A. J., & Roberto, M. (2022). Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol. Molecular psychiatry, 10.1038/s41380-022-01642-3. https://doi.org/10.1038/s41380-022-01642-3
- Patel, R. R., Wolfe, S. A., Bajo, M., Abeynaike, S., Pahng, A., Borgonetti, V., D'Ambrosio, S., Nikzad, R., Edwards, S., Paust, S., Roberts, A. J., & Roberto, M. (2021). IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake. Progress in neurobiology, 199, 101952. https://doi.org/10.1016/j.pneurobio.2020.101952
- Patel, R. R., Khom, S., Steinman, M. Q., Varodayan, F. P., Kiosses, W. B., Hedges, D. M., Vlkolinsky, R., Nadav, T., Polis, I., Bajo, M., Roberts, A. J., & Roberto, M. (2019). IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala. Brain, behavior, and immunity, 75, 208–219. https://doi.org/10.1016/j.bbi.2018.10.009
References
[1] Reesha Patel Lab. (n.d.) Retrieved November 7, 2022 from https://reeshapatellab.org/
[2] The Trustees of Indiana University. (n.d.). Theodore Cummins, Ph.D. School of Science: IUPUI. Retrieved November 8, 2022, from https://science.iupui.edu/people-directory/people/cummins-theodore.html
[3] Patel, Reesha R. (2016). Nav1. 1 and Nav1. 6: Electrophysiological properties, epilepsy-associated mutations and therapeutic targets. [Doctoral Dissertation, Indiana University-Purdue].
[4] Patel, R. R., Khom, S., Steinman, M. Q., Varodayan, F. P., Kiosses, W. B., Hedges, D. M., Vlkolinsky, R., Nadav, T., Polis, I., Bajo, M., Roberts, A. J., & Roberto, M. (2019). IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala. Brain, behavior, and immunity, 75, 208–219. https://doi.org/10.1016/j.bbi.2018.10.009
[5] Patel, R. R., Wolfe, S. A., Bajo, M., Abeynaike, S., Pahng, A., Borgonetti, V., D'Ambrosio, S., Nikzad, R., Edwards, S., Paust, S., Roberts, A. J., & Roberto, M. (2021). IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake. Progress in neurobiology, 199, 101952. https://doi.org/10.1016/j.pneurobio.2020.101952
[6] Patel, R. R., Wolfe, S. A., Borgonetti, V., Gandhi, P. J., Rodriguez, L., Snyder, A. E., D'Ambrosio, S., Bajo, M., Domissy, A., Head, S., Contet, C., Dayne Mayfield, R., Roberts, A. J., & Roberto, M. (2022). Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol. Molecular psychiatry, 10.1038/s41380-022-01642-3. https://doi.org/10.1038/s41380-022-01642-3
[7] U.S. Department of Health and Human Services. (n.d.). Search Results: Reesha Patel. NIH RePORT. Retrieved November 7, 2022, from https://reporter.nih.gov/search/Kbp7PP2cP0an_i2AstY05g/projects
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