SAP Domain

The SAF-A/B, Acinus, and PIAS (SAP) domain is a small, 35 amino acid motif named after SAF-A/B, Acinus and PIAS, three proteins that contain it.^[1]. The SAP domain sequence is found in various proteins involved in RNA processing, DNA repair, and chromatin organization^[1]. The SAP domain is predicted to contain two to three amphipathic alpha helices^[2]^[3]

References

↑ ^1.0 ^1.1 Aravind, L.; Koonin, Eugene V. (1 March 2000). "SAP – a putative DNA-binding motif involved in chromosomal organization". Trends in Biochemical Sciences. 25 (3): 112–114. doi:10.1016/s0968-0004(99)01537-6. ISSN 0968-0004. PMID 10694879.
↑ Hnízda, Aleš; Tesina, Petr; Nguyen, Thanh-Binh; Kukačka, Zdeněk; Kater, Lukas; Chaplin, Amanda K.; Beckmann, Roland; Ascher, David B.; Novák, Petr; Blundell, Tom L. (29 January 2021). "SAP domain forms a flexible part of DNA aperture in Ku70/80". The FEBS Journal. 288 (14): 4382–4393. doi:10.1111/febs.15732. ISSN 1742-464X. PMC 8653891 Check |pmc= value (help). PMID 33511782 Check |pmid= value (help).
↑ Payliss, Brandon J.; Tse, Ying Wah E.; Reichheld, Sean E.; Lemak, Alexander; Yun, Hwa Young; Houliston, Scott; Patel, Ayushi; Arrowsmith, Cheryl H.; Sharpe, Simon; Wyatt, Haley D.M. (25 October 2022). "Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease". Cell Reports. 41 (4): 111537. doi:10.1016/j.celrep.2022.111537. ISSN 2211-1247. PMID 36288699 Check |pmid= value (help).

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[:0-1] 1.0 ^1.1 Aravind, L.; Koonin, Eugene V. (1 March 2000). "SAP – a putative DNA-binding motif involved in chromosomal organization". Trends in Biochemical Sciences. 25 (3): 112–114. doi:10.1016/s0968-0004(99)01537-6. ISSN 0968-0004. PMID 10694879.

[2] Hnízda, Aleš; Tesina, Petr; Nguyen, Thanh-Binh; Kukačka, Zdeněk; Kater, Lukas; Chaplin, Amanda K.; Beckmann, Roland; Ascher, David B.; Novák, Petr; Blundell, Tom L. (29 January 2021). "SAP domain forms a flexible part of DNA aperture in Ku70/80". The FEBS Journal. 288 (14): 4382–4393. doi:10.1111/febs.15732. ISSN 1742-464X. PMC 8653891 Check |pmc= value (help). PMID 33511782 Check |pmid= value (help).

[3] Payliss, Brandon J.; Tse, Ying Wah E.; Reichheld, Sean E.; Lemak, Alexander; Yun, Hwa Young; Houliston, Scott; Patel, Ayushi; Arrowsmith, Cheryl H.; Sharpe, Simon; Wyatt, Haley D.M. (25 October 2022). "Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease". Cell Reports. 41 (4): 111537. doi:10.1016/j.celrep.2022.111537. ISSN 2211-1247. PMID 36288699 Check |pmid= value (help).

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