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Sergio Lavandero

From EverybodyWiki Bios & Wiki




File:2IMG 5757.png
Sergio Lavandero, Chilean Scientist

Sergio Lavandero González (Santiago, September 19, 1959[1]) is a Chilean pharmaceutical chemist[2] and doctor in biochemistry[3]. In 2019, he was part of the 6 scientific leaders invited by the journal Nature Reviews in Cardiology, to describe the most important scientific advances in cardiovascular medicine that have occurred in the last 15 years, those that are occurring in the present and those that are projected for the next 15 years (15th Anniversary Viewpoint, Nature Reviews Cardiology, 2019)[4]. In 2020, he was recognized by Expertscape as the number one in Latin America and Chile, regarding research on the heart and cardiac mitochondria for the last ten years[5][6][7]

In the field of teaching and scientific research, he is dedicated to the area of signal transduction of cardiovascular diseases[8]. Currently, he is a full professor at the Faculty of Chemical and Pharmaceutical Sciences & Faculty of Medicine of the University of Chile, adjunct professor at the University of Texas Southwestern Medical Center, director and researcher of the Advanced Center for Chronic Diseases (ACCDiS) and researcher at the Center for Molecular Studies of the Cell (CEMC)[9].

Biography

He studied at the Instituto Nacional and then he began to study Chemistry and Pharmacy at the University of Chile, continuing his doctoral studies in biochemistry at the same university[3]. He obtained his doctorate degree with the thesis supervised by Professor Mario Sapag-Hagar. He studied the role of growth factors in the development and function of breast tissue[10]. He also have been improved in various institutions: National Heart & Lung Institute of the Imperial College of Science, Technology & Medicine (London, England), Erasmus Universitat (Rotterdam, Holland), National Institutes of Health (Bethesda, USA), St. Vincent's Hospital, Research Cardiovascular Center (Melbourne, Australia) and the University of Texas Southwestern Medical Center (Dallas, Texas, USA)[3].

Within the University of Chile, he has held positions in the university administration such as: member of the Higher Commission for Academic Qualification (2008 and 2010); member of the Evaluation Council (2010 and 2012); Vice Chancellor for Research and Development of the University of Chile (2012-2014)[11] and currently serves as a University Senator in the period from 2018 to 2022[8].

Line of research

His research focuses on the communication systems that control the various normal cellular functions and their alterations that lead to the genesis and development of cardiovascular diseases and diabetes, both highly prevalent pathologies in Chile and worldwide[12][13][14]. His studies as a researcher have been financed by multiple national and international projects: such as the National Fund for Scientific and Technological Development (FONDECYT), Science and Technology Research Ring, Regional Associative Project for Scientific Dissemination and Assessment and Technological EXPLORA, Fund for the Promotion of Scientific and Technological Development (FONDEF) and Fund for Financing Research Centers in Priority Areas (FONDAP)[3].

His research focuses on the discovery of new mechanisms in the development of cardiovascular diseases, which are the number one cause of death worldwide, and are estimated to claim 17.9 million lives each year (31% of deaths global)[15].

a) New mechanisms in the development of cardiovascular diseases. He described ideas, mechanisms and cellular processes that occur in the genesis and development of cardiac pathologies as well as potential therapeutic targets for their treatment[16][17][18][19][20][21][22].

b) Angiotensin-(1-9); new regulator of the function and structure of the cardiovascular system. In collaboration with doctors María Paz Ocaranza, Jorge Jalil and Mario Chiong, they described at the first time, that the peptide angiotensin-(1-9) generated by ACE2 from angiotensin I, it is a new regulator of the functioning and structure of the cardiovascular system. This peptide has cardioprotective, anti-hypertensive, anti-inflammatory and anti-fibrotic actions. The ACE2 system, angiotensin-(1-7) and angiotensin-(1-9) are considered both a counterregulator of the ACE/angiotensin II system and a new pharmacological target[23][24]. Interestingly, ACE2 is also the receptor for the coronavirus SARS-CoV-2. This virus destroys ACE2 and probably alters the activity of this new counterregulatory system[25].

Public health policies and scientific dissemination

  • Creation and direction of the first Chilean Center for the study of Chronic Diseases Advanced Center for Chronic Diseases, (ACCDiS) formed by the University of Chile and the Pontifical Catholic University of Chile[8]. In ACCDiS, transdisciplinary research is carried out on cardiovascular diseases and cancer; it also forms advanced human capital, develops a national and international scientific collaboration network and contributes to the development of public health policies[26][27][28][29]. This institution studies for the first time in Chile, the natural history of chronic non-communicable diseases through the Maule Cohort (MAUCO)[30]. Recently, ACCDiS ranked 3rd (2246 of the total) among all the Chilean research institutions in the SCImago Institutions Ranking (SIR) 2020, after the University of Chile and the Pontificia Universidad Católica de Chile, who were ranked according to a combination of three performance indicators: research, innovation and social impact[31].
  • Installation and initial management of the Regional Associative Project for Scientific and Technological Dissemination and Assessment EXPLORA: PAR Explora Northern Metropolitan Region (2019-2022). Its principal aim is to summon girls, boys, young people and adults to participate in activities for the dissemination and assessment of science and technology, arousing curiosity and bringing them closer to knowledge from different scientific areas. This project also allows educating and disseminating to society issues related to chronic non-communicable diseases and their prevention. Its actions cover 33% of the population of the Metropolitan Region (approximately 410,000 preschool, basic and secondary education students) who reside in 17 communes in the north and east area[32][33].

Job Positions

  • Director and Principal Investigator of the Advanced Center for Chronic Diseases[34][35] (ACCDIS).
  • Full Professor of the Faculty of Chemical and Pharmaceutical Sciences and the Faculty of Medicine of the University of Chile[3].
  • Full member of the Chilean Academy of Sciences[37] and the Latin American Academy of Sciences[38].
  • Member of the external editorial committee of Nature Reviews in Cardiology[39].
  • Adjunct Professor at the University of Texas Southwestern Medical Center (Dallas, USA)[40].
  • Full member and President of the Academy of Pharmaceutical Sciences of Chile (period 2017-2020)[6][41].
  • International evaluator of the Ibero-American Program of Science and Technology for Development (CYTED)[42].
  • Institutional Advisor to the Regional Associative Project for Scientific and Technological Dissemination and Assessment EXPLORA, Metropolitan Region[43].
  • Vice President of the Chilean Academy of Science[44].

Awards and honours

  • Andes Foundation Doctoral Scholarship (1988-1991)[45]
  • Boehringer-Mannheim Prize for Young Researcher in Basic Research in Cardiology (1994).[11]
  • British-Council Post-doctoral Fellowship (1996).[11]
  • Chilean Foundation of Cardiology Awards for the best basic research in 1996, 1998 and 2005.[11]
  • Global Level Expert in the Heart Area 2021, by Expertscape.[7]
  • Conference Osvaldo Cori, by the SBBMCH (2021)[46]

References

  1. ↑ "Lavandero González, Sergio Alejandro | ACAL". www.acal-scientia.org. Retrieved 2022-02-23.
  2. ↑ "Tesis de Pregrado Sergio Lavandero". www.bibliotecadigital.uchile.cl. Retrieved 2022-02-23.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 "Portafolio Académico - Sergio Alejandro Lavandero González". www.uchile.cl. Retrieved 2022-02-23.
  4. ↑ Kalman, Jonathan M.; Lavandero, Sergio; Mahfoud, Felix; Nahrendorf, Matthias; Yacoub, Magdi H.; Zhao, Dong (November 2019). "Looking back and thinking forwards — 15 years of cardiology and cardiovascular research". Nature Reviews Cardiology. 16 (11): 651–660. doi:10.1038/s41569-019-0261-7. ISSN 1759-5010. PMID 31570832. Unknown parameter |s2cid= ignored (help)
  5. ↑ Palma, Lorenzo. "Sergio Lavandero es reconocido como el científico N°1 de Latinoamérica en investigación cardiovascular | Ciencia en Chile" (in español). Retrieved 2022-02-23.
  6. ↑ 6.0 6.1 "Myocardium: Worldwide - Expertscape.com". www.expertscape.com. Retrieved 2022-02-23.
  7. ↑ 7.0 7.1 "Myocardium: Lavandero, S - Expertscape.com". www.expertscape.com. Retrieved 2022-02-23.
  8. ↑ 8.0 8.1 8.2 "Sergio Alejandro Lavandero González - Universidad de Chile". uchile.cl. Retrieved 2022-02-23.
  9. ↑ "CEMC | Sergio Lavandero". cmcmed.cl. Retrieved 2022-02-23.
  10. ↑ "https://www.bibliotecadigital.uchile.cl/discovery/fulldisplay?docid=alma991006760679703936&context=L&vid=56UDC_INST:56UDC_INST&lang=es&search_scope=MyInst_and_CI&adaptor=Local%20Search%20Engine&tab=Everything&query=any,contains,Sergio%20Lavandero&facet=rtype,include,dissertations&facet=searchcreationdate,include,1983%7C,%7C2005&facet=creator,include,Lavandero%20Gonz%C3%A1lez%20Sergio&facet=creator,include,Sapag%20Hagar%20Mario&offset=0". www.bibliotecadigital.uchile.cl. Retrieved 2022-02-23. External link in |title= (help)
  11. ↑ 11.0 11.1 11.2 11.3 "Prof. Sergio Lavandero asume como nuevo Vicerrector de Investigación y Desarrollo de la U. de Chile - Universidad de Chile". uchile.cl. Retrieved 2022-02-23.
  12. ↑ "World Diabetes Day".
  13. ↑ "Ministerio de Salud de Chile".
  14. ↑ "Líneas de Investigación". Centro Avanzado de Enfermedades Crónicas (in español). Retrieved 2022-02-23.
  15. ↑ "Cardiovascular diseases (CVDs)". www.who.int. Retrieved 2022-02-23.
  16. ↑ Contreras-Briceño, Felipe; Herrera, Sebastián; Vega-Adauy, Julian; Salinas, Manuel; Ocaranza, María Paz; Jalil, Jorge E.; Mandiola, Jorge; García, Lorena; Chiong, Mario; Castro, Pablo F.; Lavandero, Sergio (2021-11-01). "Circulating Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Associated With Left Atrial Remodeling in Long-Distance Runners". Frontiers in Cardiovascular Medicine. 8: 737285. doi:10.3389/fcvm.2021.737285. ISSN 2297-055X. PMC 8591189 Check |pmc= value (help). PMID 34790706 Check |pmid= value (help).
  17. ↑ Contreras-Briceño, Felipe; Vega, Julián; Mandiola, Jorge; Ocaranza, María Paz; Herrera, Sebastián; Salinas, Manuel; Fernández, Rodrigo; Jalil, Jorge E.; Lavandero, Sergio; Chiong, Mario; Godoy, Paz (2021-09-24). "Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners". Journal of Cardiovascular Development and Disease. 8 (10): 118. doi:10.3390/jcdd8100118. ISSN 2308-3425. PMC 8541355 Check |pmc= value (help). PMID 34677187 Check |pmid= value (help).
  18. ↑ Fernández, Carolina; Torrealba, Natalia; Altamirano, Francisco; Garrido-Moreno, Valeria; Vásquez-Trincado, César; Flores-Vergara, Raúl; López-Crisosto, Camila; Ocaranza, María Paz; Chiong, Mario; Pedrozo, Zully; Lavandero, Sergio (2021-08-18). "Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy". PLOS ONE. 16 (8): e0255452. Bibcode:2021PLoSO..1655452F. doi:10.1371/journal.pone.0255452. ISSN 1932-6203. PMC 8372926 Check |pmc= value (help). PMID 34407099 Check |pmid= value (help).
  19. ↑ Olivares-Silva, Francisco; De Gregorio, Nicole; Espitia-Corredor, Jenaro; Espinoza, Claudio; Vivar, Raúl; Silva, David; Osorio, José Miguel; Lavandero, Sergio; Peiró, Concepción; Sánchez-Ferrer, Carlos; Díaz-Araya, Guillermo (2021-12-01). "Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1867 (12): 166241. doi:10.1016/j.bbadis.2021.166241. ISSN 0925-4439. PMID 34400298 Check |pmid= value (help).
  20. ↑ Gatica, Damián; Chiong, Mario; Lavandero, Sergio; Klionsky, Daniel J. (2021-05-06). "The role of autophagy in cardiovascular pathology". Cardiovascular Research. 118 (4): 934–950. doi:10.1093/cvr/cvab158. ISSN 1755-3245. PMC 8930074 Check |pmc= value (help). PMID 33956077 Check |pmid= value (help).
  21. ↑ Tong, Dan; Schiattarella, Gabriele G.; Jiang, Nan; Altamirano, Francisco; Szweda, Pamela A.; Elnwasany, Abdallah; Lee, Dong I.; Yoo, Heesoo; Kass, David A.; Szweda, Luke I.; Lavandero, Sergio (2021-05-28). "NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction". Circulation Research. 128 (11): 1629–1641. doi:10.1161/CIRCRESAHA.120.317046. PMC 8159891 Check |pmc= value (help). PMID 33882692 Check |pmid= value (help).
  22. ↑ Luo, Yuxuan; Jiang, Nan; May, Herman I.; Luo, Xiang; Ferdous, Anwarul; Schiattarella, Gabriele G.; Chen, Guihao; Li, Qinfeng; Li, Chao; Rothermel, Beverly A.; Jiang, Dingsheng (2021-07-06). "Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy". Circulation. 144 (1): 34–51. doi:10.1161/CIRCULATIONAHA.120.052384. ISSN 0009-7322. PMC 8247545 Check |pmc= value (help). PMID 33821668 Check |pmid= value (help).
  23. ↑ Mendoza-Torres, Evelyn; Oyarzún, Alejandra; Mondaca-Ruff, David; Azocar, Andrés; Castro, Pablo F.; Jalil, Jorge E.; Mario; Lavandero, Sergio; Ocaranza, María Paz (August 2015). "ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension". Therapeutic Advances in Cardiovascular Disease. 9 (4): 217–237. doi:10.1177/1753944715597623. ISSN 1753-9447. PMID 26275770. Unknown parameter |s2cid= ignored (help)
  24. ↑ Norambuena-Soto, Ignacio; Ocaranza, Maria Paz; Cancino-Arenas, Nicole; Sanhueza–Olivares, Fernanda; Paulina; Leiva–Navarrete, Sebastian; Mancilla-Medina, Cristian; Moya, Jacqueline; Novoa, Ulises; Jalil, Jorge E.; Castro, Pablo F. (2020-10-01). "Angiotensin-(1–9) prevents vascular remodeling by decreasing vascular smooth muscle cell dedifferentiation through a FoxO1-dependent mechanism". Biochemical Pharmacology. 180: 114190. doi:10.1016/j.bcp.2020.114190. ISSN 0006-2952. PMID 32768401 Check |pmid= value (help). Unknown parameter |s2cid= ignored (help)
  25. ↑ Chaudhry, Farhan; Lavandero, Sergio; Xie, Xiang; Sabharwal, Basera; Zheng, Ying-Ying; Correa, Ashish; Narula, Jagat; Phillip (2020-12-01). "Manipulation of ACE2 expression in COVID-19". Open Heart. 7 (2): e001424. doi:10.1136/openhrt-2020-001424. ISSN 2053-3624. PMC 7757413 Check |pmc= value (help). PMID 33443121 Check |pmid= value (help).
  26. ↑ "Nosotros". Centro Avanzado de Enfermedades Crónicas (in español). Retrieved 2022-02-23.
  27. ↑ "Publicaciones". Centro Avanzado de Enfermedades Crónicas (in español). Retrieved 2022-02-23.
  28. ↑ "Internacional". Centro Avanzado de Enfermedades Crónicas (in español). Retrieved 2022-02-23.
  29. ↑ "Nacional". Centro Avanzado de Enfermedades Crónicas (in español). Retrieved 2022-02-23.
  30. ↑ "MAUCO". Centro Avanzado de Enfermedades Crónicas (in español). Retrieved 2022-02-23.
  31. ↑ "Research and Innovation Rankings 2020". www.scimagoir.com. Retrieved 2022-02-23.
  32. ↑ "Quiénes Somos". www.explora.cl (in español). Retrieved 2022-02-23.
  33. ↑ "Quiénes Somos". RM Norte (in español). Retrieved 2022-02-23.
  34. ↑ "Investigadores Principales". Centro Avanzado de Enfermedades Crónicas (in español). Retrieved 2022-02-23.
  35. ↑ "Líneas de Investigación". Centro Avanzado de Enfermedades Crónicas (in español). Retrieved 2022-02-23.
  36. ↑ "Integrantes en ejercicio - Universidad de Chile". uchile.cl. Retrieved 2022-02-23.
  37. ↑ "Miembros de Número | ACADEMIA DE CIENCIAS" (in español). Archived from the original on 2022-03-03. Retrieved 2022-02-23.
  38. ↑ "Directorio de Miembros | ACAL". www.acal-scientia.org. Retrieved 2022-02-23.
  39. ↑ "Journal Credits | Nature Reviews Cardiology". www.nature.com. Retrieved 2022-02-23.
  40. ↑ "Former Members - Hill Lab - UT Southwestern Medical Center". www.utsouthwestern.edu. Retrieved 2022-02-23.
  41. ↑ "Academy of pharmaceutical sciences » Statement of the President of the Academy of pharmaceutical sciences". Retrieved 2022-02-23.
  42. ↑ "CYTED reune importante grupo de expertos en Lima para la evaluación de propuestas 2016. | CYTED. Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo". www.cyted.org. Retrieved 2022-02-23.
  43. ↑ "Quiénes Somos". RM Norte (in español). Retrieved 2022-02-23.
  44. ↑ "Sergio Lavandero, es el nuevo vicepresidente de la Academia Chilena de Ciencias". Centro Avanzado de Enfermedades Crónicas (in español). Retrieved 2022-02-23.
  45. ↑ "Prof. Sergio Lavandero González - Universidad de Chile". uchile.cl. Retrieved 2022-02-23.
  46. ↑ "Conference Osvaldo Cori" (PDF).

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