Spectradyne LLC
| Limited Liability Company | |
| ISIN | 🆔 |
| Industry | microfluidics |
| Founded 📆 | 2013 |
| Founders 👔 | Jean-Luc Fraikin (CEO), Peter Meinhold, Franklin Monzon, Andrew N Cleland |
| Headquarters 🏙️ | , Torrance CA , USA |
Area served 🗺️ | |
| Products 📟 | Analytic instrumentation |
| Members | |
Number of employees | |
| 🌐 Website | http://www.nanoparticleanalyzer.com |
| 📇 Address | |
| 📞 telephone | |
Spectradyne LLC is a privately-held, limited liability company based in Torrance, California. Founded in 2013, the company has implemented a patented form of the resistive pulse sensing (RPS) technology, using a microfluidic format, where this technique is known as microfluidic resistive pulse sensing, or MRPS.
The capabilities covered by Spectradyne LLC’s product range include high resolution particle sizing, size distribution measurement, and concentration analysis.
Technology
Spectradyne LLC’s technology is focused on detecting individual particles in weakly conducting fluids such as phosphate-buffered saline (PBS) or other biologically-compatible fluids, including blood serum and other bodily fluids. Using an implementation of microfluidic resistive pulse sensing (MRPS), individual particles suspended in the fluid pass through a nanoconstriction in a microfluidic cartridge, changing the electrical resistance of the fluid in the constriction by an amount proportional to the size of the particle. These individual events are digitized and analyzed, and the instrument then provides data in the form of absolute concentration as a function of particle diameter.
Products
The nCS1 is the firm's principal product. This instrument provides pressure control and electrical power to a disposable microfluidic cartridge that is inserted into the instrument. Electrical signals from the cartridge, generated as particles pass through the nanopore at the heart of the cartridge, are digitized and analyzed using custom software.
Spectradyne LLC sells a range of different cartridge designs, the TS-300, the TS-400 and the TS-2000, each optimized for a different range of particle sizes. Together these cartridges cover a range of particles from below 50 nm to above 1 micron in diameter, over four orders of magnitude in volume.
The technology in the nCS1 and its microfluidic cartridges was developed at the University of California, Santa Barbara by two of the company founders. A paper describing this technology was published in Nature Nanotechnology in 2011[1].
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References
- ↑ J.-L. Fraikin, T. Teesalu, C.M. McKenney, E. Ruoslahti and A.N. Cleland, “A high-throughput label-free nanoparticle analyzer,” Nature Nanotechnology 6, 308-313 (2011)
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