Stephanie Schorge
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Stephanie Schorge is a Professor of Neuroscience in the Department of Neuroscience, Physiology and Pharmacology at University College London (UCL)[1][2][3][4][5].
Education and career[edit]
Schorge grew up in Lenox MA, USA and attended Yale University, graduating with a BS in 1994[2]. She obtained a PhD in Neuroscience from Brown University[5], working with Diane Lipscombe on RNA processing in voltage gated calcium channels[6] [7][paper Schorge et al., Nature Neuroscience 1999]. In 1999 Schorge moved to the UK to join the UCL Department of Pharmacology as a postdoctoral researcher[1][8] in single channel biophysics of NMDA receptors[9] [10] with David Colquhoun. In 2005 she began a short post-doctoral position with Dimitri Kullmann at UCL Institute of Neurology (ION)[8], investigating the functional impacts of mutations in ion channels that are linked to human neurological disorders, the channelopaties[11]. She obtained her first Fellowship from the Worshipful Company of Pewterers in late 2005[3], for which she began looking at genetics and functions of mutations linked to epilepsy, particularly in sodium channels[12]. She obtained her second fellowship, a University Research Fellowship (URF), from the Royal Society[1] in 2010, and this was renewed in 2015, allowing her to consolidate a collaboration with Kullmann and Matthew Walker exploring potential gene therapy treatments for epilepsy[13] [Wykes et al., 2013 Science Translational medicine]. In 2017 along with Kullmann and Walker, Schorge obtained funding from the MRC to carry out a first in human trial for gene therapy in epilepsy[14] [ClinicalTrials.gov Identifier: NCT04601974; EudraCT Number: 2019-000923-41].
In 2018 Schorge moved to the UCL School of Pharmacy (SoP) to become Professor in Translational Neuroscience, and Head of the Research Department of Pharmacology[1], with the aim of streamlining the translation of a growing portfolio gene therapy research into clinical applications particularly by supporting the UCL GeneTxNeuro core facility for production of gene therapy tools for UCL. The Gene Therapy for Epilepsy collaboration expanded to include Gabriele Lignani at the ION[15], and to encompass new potential gene therapy treatments using CRISPR[16] [17][Colasante et al., 2020] and DREADDs [18][Katzel et al., 2014 Nat Comm].
In 2021 she moved again and became Head of the Research Department of Neuroscience, Physiology and Pharmacology (NPP), in the UCL Division of Biosciences[2]. Schorge is currently working to build links between NPP, ION and SoP, as well as working with the Translational Research Office to build a virtual pipeline leading from basic science to clinical delivery to support translational research across UCL.
Research[edit]
Stephanie Schorge has a long-standing interest in how mutations in ion channels can cause neurological disease[8], and conversely how manipulating ion channels can be used to treat disease. Along with her collaborators, Schorge is currently working to translate a portfolio of gene therapy approaches to first in human clinical trials to treat severe drug-refractory epilepsy[19]. Schorge has published 115 scientific articles.[3][1]
References[edit]
- ↑ 1.0 1.1 1.2 1.3 1.4 "Dr. Stephanie Schorge - AcademiaNet". www.academia-net.org. Retrieved 2022-01-06.
- ↑ 2.0 2.1 2.2 UCL (2021-07-12). "Prof Stephanie Schorge". UCL Division of Biosciences. Retrieved 2022-01-06.
- ↑ 3.0 3.1 3.2 "Iris View Profile". iris.ucl.ac.uk. Retrieved 2021-12-30.
- ↑ "Stephanie Schorge". scholar.google.co.uk. Retrieved 2022-01-06.
- ↑ 5.0 5.1 "ORCID". orcid.org. Retrieved 2022-01-06.
- ↑ Schorge, S.; Gupta, S.; Lin, Z.; McEnery, M. W.; Lipscombe, D. (1999-09-02). "Calcium channel activation stabilizes a neuronal calcium channel mRNA". Nature Neuroscience. 2 (9): 785–790. doi:10.1038/12153. ISSN 1097-6256. PMID 10461216. Unknown parameter
|s2cid=
ignored (help) - ↑ Lin, Z.; Lin, Y.; Schorge, S.; Pan, J. Q.; Beierlein, M.; Lipscombe, D. (1999-07-01). "Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calcium channels in central and peripheral neurons". The Journal of Neuroscience: The Official Journal of the Society for Neuroscience. 19 (13): 5322–5331. doi:10.1523/JNEUROSCI.19-13-05322.1999. ISSN 0270-6474. PMC 6782300 Check
|pmc=
value (help). PMID 10377343. - ↑ 8.0 8.1 8.2 Admin, ERUK (2019-05-09). "Stephanie Schorge | Epilepsy Research UK". epilepsyresearch.org.uk. Retrieved 2022-01-06.
- ↑ Schorge, Stephanie; Elenes, Sergio; Colquhoun, David (2005-12-01). "Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits". The Journal of Physiology. 569 (Pt 2): 395–418. doi:10.1113/jphysiol.2005.095349. ISSN 0022-3751. PMC 1464248. PMID 16223763.
- ↑ Schorge, Stephanie; Elenes, Sergio; Colquhoun, David (2005). "Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits". The Journal of Physiology. 569 (2): 395–418. doi:10.1113/jphysiol.2005.095349. ISSN 1469-7793. PMC 1464248. PMID 16223763.
- ↑ Schorge, Stephanie (2018-02-14). "Channelopathies go above and beyond the channels". Neuropharmacology. 132: 1–2. doi:10.1016/j.neuropharm.2018.02.011. ISSN 1873-7064. PMID 29454019. Unknown parameter
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ignored (help) - ↑ Tate, Sarah K.; Depondt, Chantal; Sisodiya, Sanjay M.; Cavalleri, Gianpiero L.; Schorge, Stephanie; Soranzo, Nicole; Thom, Maria; Sen, Arjune; Shorvon, Simon D.; Sander, Josemir W.; Wood, Nicholas W. (2005-04-12). "Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin". Proceedings of the National Academy of Sciences of the United States of America. 102 (15): 5507–5512. Bibcode:2005PNAS..102.5507T. doi:10.1073/pnas.0407346102. ISSN 0027-8424. PMC 556232. PMID 15805193.
- ↑ Wykes, Robert C.; Heeroma, Joost H.; Mantoan, Laura; Zheng, Kaiyu; MacDonald, Douglas C.; Deisseroth, Karl; Hashemi, Kevan S.; Walker, Matthew C.; Schorge, Stephanie; Kullmann, Dimitri M. (2012-11-21). "Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy". Science Translational Medicine. 4 (161): 161ra152. doi:10.1126/scitranslmed.3004190. PMC 3605784. PMID 23147003.
- ↑ "CTG Labs - NCBI". beta.clinicaltrials.gov. Retrieved 2021-12-30.
- ↑ UCL (2020-06-04). "Dr Gabriele Lignani". UCL Queen Square Institute of Neurology. Retrieved 2022-01-06.
- ↑ Colasante, Gaia; Qiu, Yichen; Massimino, Luca; Di Berardino, Claudia; Cornford, Jonathan H.; Snowball, Albert; Weston, Mikail; Jones, Steffan P.; Giannelli, Serena; Lieb, Andreas; Schorge, Stephanie (2020-03-01). "In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy". Brain: A Journal of Neurology. 143 (3): 891–905. doi:10.1093/brain/awaa045. ISSN 1460-2156. PMC 7089667 Check
|pmc=
value (help). PMID 32129831 Check|pmid=
value (help). - ↑ Colasante, Gaia; Lignani, Gabriele; Brusco, Simone; Di Berardino, Claudia; Carpenter, Jenna; Giannelli, Serena; Valassina, Nicholas; Bido, Simone; Ricci, Raffaele; Castoldi, Valerio; Marenna, Silvia (2020-01-08). "dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice". Molecular Therapy: The Journal of the American Society of Gene Therapy. 28 (1): 235–253. doi:10.1016/j.ymthe.2019.08.018. ISSN 1525-0024. PMC 6952031 Check
|pmc=
value (help). PMID 31607539. - ↑ Kätzel, Dennis; Nicholson, Elizabeth; Schorge, Stephanie; Walker, Matthew C.; Kullmann, Dimitri M. (2014-05-27). "Chemical-genetic attenuation of focal neocortical seizures". Nature Communications. 5: 3847. Bibcode:2014NatCo...5.3847K. doi:10.1038/ncomms4847. ISSN 2041-1723. PMC 4050272. PMID 24866701.
- ↑ "Engineered Potassium Channel gene therapy for epilepsy". UK Research and Innovation. Retrieved 2022-01-07. Unknown parameter
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External links[edit]
- University College London
- Stephanie Schorge publications indexed by Google Scholar
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