Synchron, Inc.
Synchron, Inc. is a technology company building implantable neural interface solutions, including the world's first endovascular brain-computer interface, originally envisioned by Thomas Oxley, MD, PhD. The company, which was spun out of the University of Melbourne, is initially targeting novel therapies for paralysis due to a range of neurological conditions. In a recently approved first in human clinical trial, the company is assessing the safety of the Stentrode[1] and BrainOS,[2] a platform API technology enabling hands-free user control of third-party assistive technologies. Other applications of the platform may include therapies for epilepsy and movement disorders.
History[edit]
Company co-founder and CEO Thomas Oxley a neurointerventionist at Mount Sinai Hospital in New York City, conceived the idea for the Stentrode in 2007. In 2010, Oxley made a cold-call pitch to Colonel Geoffrey Ling at the United States Army with a new concept for a brain-computer interface.[3] Funding for Synchron’s technology commenced in 2012 and included grants from U.S. Defense Advanced Research Projects Agency (DARPA), United States Department of Defense (DoD) and the National Health and Medical Research Council of Australia, among other sources. Oxley’s group in Australia was the only non-US-based funded by DARPA as part of the Reliable Neural Interfaces Technology (RE-NET) program.[4]
Oxley founded the Australian startup SmartStent in 2012, which was flipped into Synchron in 2016,[5] the company continues to have close ties to the Vascular Bionics Laboratory in the Department of Medicine (Royal Melbourne Hospital), University of Melbourne. In 2016, the group published a seminal proof-of-concept paper in Nature Biotechnology, demonstrating the potential for a neural recording device to be engineered onto a stent and chronically implanted into a blood vessel in the brain, without the need for open brain surgery. The company is working towards a first-in-human clinical trial of a pioneering minimally invasive brain-computer interface Stentrode technology for the direct thought-control of operating systems and a suite of assistive technology applications for patients with paralysis. The Stentrode technology has achieved widespread international media attention, including an endorsement by then-President Obama subsequently highlighted the potential benefit of the Stentrode technology in a video on Discovery’s Science Channel.
In 2017, Series A funding was led by NeuroTechnology Investors, and veteran neurovascular entrepreneur Martin Dieck took on the role of Chairman of the Board. In 2018, Dr. Oxley announced in a TEDxSyndey Talk that the company, Synchron, would initiate clinical trials of the Stentrode device with the goal of assisting paralyzed patients to regain the ability to communicate.
In 2019, a statement from FDA Commissioner Scott Gottlieb, M.D., he lent support to the industry, issuing draft guidance to help spur the development of brain-computer interface (BCI) devices.[6]
References[edit]
- ↑ "STENTRODE First in Human Early Feasibility Study (SWITCH)". ClinicalTrials.gov. U.S. National Library of Medicine. Retrieved 2019-07-03.
- ↑ "Synchron Initiates First-ever Clinical Trial to Evaluate Thought-to-Text™ Brain-Computer Interface Technology in Patients with Severe Paralysis". Biospace.com. BioSpace. Retrieved 2019-07-03.
- ↑ Margo, Jill. "The prosthesis that can read your mind and move your limbs". afr.com. Financial Review. Retrieved 2019-07-03.
- ↑ "Reliable Neural-Interface Technology (RE-NET)". darpa.mil. Defense Advanced REsearch Projects Agency. Retrieved 2019-07-03.
- ↑ Densford, Fink. "Neural interface developer Synchron raises $10m in Series A". massdevice.com. Mass Device. Retrieved 2019-07-03.
- ↑ "Statement from FDA Commissioner Scott Gottlieb, M.D., on efforts to spur development of innovative devices, including new advancements in novel brain implants, that can help patients with paralysis or amputation gain mobility". fda.gov. US Food & Drug Administration. Retrieved 2019-07-03.
External links[edit]
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