Synthetic Notch Protein
Synthetic notch protein receptors are present in most animals. It is theorized and documented to help treat cancers, though testing is in early phases.
Synthetic notch (SynNotch) chimeric antigen receptors (CARs), also known as SynNotch-CAR, has been shown to help fight glioblastoma, astrocytoma, and meningioma. For example, Synthetic notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma[1] Another example, Multi-antigen prime-and-kill recognition circuits provide flexibility and precision to overcome these challenges in the context of glioblastoma[2]
SynNotch can be described as mimicking the molecular design from mother nature with alterations to combat what you don't want. In classic treatments such as leukemia, it would also target healthy cells. SynNotch CAR T cells can target only the cancerous cells while leaving the good healthy cells alone. It's like going from a shotgun to a programmed sniper rifle. You're sniping in the brain.[3] Said by Liem Le from the Talks With Liem Le video podcast.
References
- ↑ Choe, Joseph H.; Watchmaker, Payal B.; Simic, Milos S.; Gilbert, Ryan D.; Li, Aileen W.; Krasnow, Nira A.; Downey, Kira M.; Yu, Wei; Carrera, Diego A.; Celli, Anna; Cho, Juhyun (2021-04-28). "SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma". Science Translational Medicine. 13 (591): eabe7378. doi:10.1126/scitranslmed.abe7378. PMC 8362330 Check
|pmc=value (help). PMID 33910979 Check|pmid=value (help). - ↑ Choe, Joseph H.; Watchmaker, Payal B.; Simic, Milos S.; Gilbert, Ryan D.; Li, Aileen W.; Krasnow, Nira A.; Downey, Kira M.; Yu, Wei; Carrera, Diego A.; Celli, Anna; Cho, Juhyun (2021-04-28). "SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma". Science Translational Medicine. 13 (591): eabe7378. doi:10.1126/scitranslmed.abe7378. ISSN 1946-6242. PMC 8362330 Check
|pmc=value (help). PMID 33910979 Check|pmid=value (help). - ↑ Curing Brain Cancer With Doctor Milos Simic, retrieved 2021-09-02
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