TNMpilot
Type of site | Web-based bioinformatics platform |
|---|---|
| Available in | English |
| Created by | Ádám Bartha; Balázs Győrffy |
| Website | [1](https://tnmplot.com) |
| Commercial | no |
| Registration | Not required |
| Launched | 2021 |
TNMplot.com is an open-access bioinformatics web platform designed to compare gene expression levels across normal, tumor, and metastatic tissue samples. The tool provides a user-friendly interface to support translational cancer research by enabling researchers to analyze gene-level RNA expression across thousands of samples without requiring coding experience.[1]
Background and features
The platform was developed by researchers at Semmelweis University in Budapest, Hungary, and launched in 2021. TNMplot.com integrates multiple transcriptomic datasets from public repositories, including Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and GTEx, allowing users to perform differential gene expression analyses between normal, malignant, and metastatic samples.
TNMplot offers a range of statistical comparisons using non-parametric tests such as Mann–Whitney U and Kruskal–Wallis, along with visualization tools like boxplots and violin plots. Users can search genes by symbol and customize the dataset selection to focus on specific tissue types or cancer subtypes.
Scientific relevance
The TNMplot.com platform was formally described in a peer-reviewed scientific publication in the International Journal of Molecular Sciences, where its methodology, data curation and validation processes were detailed. The authors highlighted its utility in identifying cancer-specific expression patterns and potential biomarkers by enabling reproducible gene-level comparisons.
Applications
Researchers have used TNMplot.com to:
- compare gene expression profiles between tumor and adjacent normal tissues,
- explore candidate diagnostic and prognostic biomarkers,
- validate transcriptomic signatures across independent datasets,
- generate publication-ready visualizations for presentations and manuscripts.
See also
== References ==
- ↑ Bartha, Ádám; Győrffy, Balázs (2021). "TNMplot.com: A web tool for the comparison of gene expression in normal, tumor and metastatic tissues". International Journal of Molecular Sciences. 22 (5): 2622. doi:10.3390/ijms22052622. PMC 7961455 Check
|pmc=value (help). PMID 33807717 Check|pmid=value (help).
External links
- [[2](https://tnmplot.com) Official website]
Category:Web applications Category:Cancer research
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