Texas Biomedical Device Center
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| Texas Biomedical Device Center | |
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The Texas Biomedical Device Center (TxBDC) specializes in the creation of biomedical devices to combat neurological injury and disease. Founded in 2012 with donations from Texas Instruments and a private donor[1], it is maintained and hosted by The University of Texas at Dallas and is led by Michael Kilgard, Interim Executive Director and Chief Science Officer; Robert Rennaker, Associate Director and Chief Technology Officer; Seth Hays, Director of Preclinical Research; and Jane Wigginton, Chief Medical Officer. [2]
Devices[edit]
Vagus Nerve Stimulator Systems[edit]
The TxBDC has developed a system it calls "Targeted Plasticity Therapy", which uses an implantable vagus nerve stimulator along with physical therapy to improve the results of therapy.[3] The center has developed 4 classes of vagus nerve stimulator systems, classified by what ailment these stimulators treat.
ReThink:[edit]
ReThink can be used to treat PTSD by reducing the fear response in patients. Vagus nerve stimulation is used alongside therapy with a licensed therapist once a week. The therapist records the session on the TxBDC smart phone app and adds cues to stimulate the vagus nerve when triggers are mentioned. The patient can then listen to the recorded therapy session and receive vagus nerve stimulation afterwards.[4]
RePlay/ReTrieve:[edit]
RePlay can be used to aid physical therapy for upper limb recovery using controllers that measure hand and arm movements to trigger vagus nerve stimulation. These controllers include: a knob, similar to a doorknob, that rotates, a pinch controller to practice opening and closing one's fingers, a wrist controller that practices moving one's wrist back and forth, and a twist controller similar to a lid found on a water bottle. These controllers allow video games to be played that emphasize specific hand movements.
ReTrieve is used as an emphasis for motor and tactile function in the hand using differently shaped and textured objects to be retrieved given a prompt, veiled by a machine that gives the prompt to retrieve a specific object. As the patient improves their abilities, the shapes become incrementally harder to distinguish.[5]
RePair:[edit]
RePair can be used to aid physical therapy for arm and leg recovery by pairing sensors on the arms and legs with vagus nerve stimulation. The TxBDC smart phone app is then able to trigger vagus nerve stimulation during daily activities.[6]
ReLief:[edit]
ReLief can be used to treat tinnitus by pairing sound with vagus nerve stimulation. This is done by playing sounds, above and below the perceived frequency caused by tinnitus, to shrink the hyperactive part of the brain responsible for tinnitus.[7]
The TxBDC intends to use vagus nerve stimulation to treat strokes, tinnitus, spinal cord injury, traumatic brain injury, PTSD, and peripheral nerve injury.[8]
Additional Devices[edit]
In 2014, the TxBDC developed a set of devices that could detect concussions. The first part uses an array of sensors to detect the force, frequency, and direction of a taken hit. After sustaining a severe impact, the second part involves a set of goggles that tracks eye motion to detect whether or not the user's visual tracking ability is impaired.[9]
Research[edit]
Since 2012, the TxBDC has made 157 publications documenting their research, with 15 of them being patents. Many of these studies document their developments in neuroplasticity.[10] It has also coordinated 3 clinical trials covering Vagus Nerve Stimulation to treat stroke[11], spinal cord injury[12], and PTSD[13], respectively, that are currently ongoing.[14]
In 2015, the TxBDC was awarded a four-year grant from DARPA that resulted in funding up to $6.4 million for their potential treatment of PTSD using "Targeted Plasticity Therapy".[15]
In 2021, the FDA approved the TxBDC's "Targeted Plasticity Therapy" for the potential treatment of stroke.[16]
References[edit]
- ↑ "About TxBDC". Unknown parameter
|url-status=ignored (help) - ↑ "TxBDC Leadership". Unknown parameter
|url-status=ignored (help) - ↑ "TxBDC - Research". Unknown parameter
|url-status=ignored (help) - ↑ "TxBDC - ReThink Technology".
- ↑ "TxBDC RePlay/ReTrieve Technology".
- ↑ "TxBDC - RePair Technology".
- ↑ "TxBDC - ReLief Technologies".
- ↑ "TxBDC - Possibilities".
- ↑ "TxBDC - Reducing Concussions" (PDF). Unknown parameter
|url-status=ignored (help) - ↑ "TxBDC - Publications". Unknown parameter
|url-status=ignored (help) - ↑ "TxBDC - Stroke Recovery Clinical Trial". Unknown parameter
|url-status=ignored (help) - ↑ "TxBDC - Spinal Cord Injury Clinical Trial". Unknown parameter
|url-status=ignored (help) - ↑ "TxBDC - PTSD Clinical Trial". Unknown parameter
|url-status=ignored (help) - ↑ "TxBDC - Clinical Trials". Unknown parameter
|url-status=ignored (help) - ↑ "Team Wins DARPA Grant to Explore Potential Treatment for PTSD". Unknown parameter
|url-status=ignored (help) - ↑ "FDA Approves Stroke Rehabilitation Therapy Created at UT Dallas". Unknown parameter
|url-status=ignored (help)
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