Tolufazepam

Tolufazepam
Identifiers
	IUPAC name 7-chloro-5-(2-chlorophenyl)-1-[2-(4-methylphenyl)sulfonylethyl]-3H-1,4-benzodiazepin-2-one;
CAS Number	86273-92-9 ;
PubChem CID	65647;
ChemSpider	59084 ;
UNII	98SR74X50D;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C24H20Cl2N2O3S
Molar mass	487.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc2ccccc2C(=NCC1=O)c3cc(Cl)ccc3N1CCS(=O)(=O)c(cc4)ccc4C;
	InChI InChI=1S/C24H20Cl2N2O3S/c1-16-6-9-18(10-7-16)32(30,31)13-12-28-22-11-8-17(25)14-20(22)24(27-15-23(28)29)19-4-2-3-5-21(19)26/h2-11,14H,12-13,15H2,1H3 ; Key:FFZOBTGTWSRRMB-UHFFFAOYSA-N ;
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Tolufazepam is a drug that is a benzodiazepine derivative.^[1] Studies have shown tolufazepam to have anticonvulsant and anxiolytic activity in animal subjects,^[2] including convulsions elicited by pentylenetetrazol.^[3]

References

↑ "List of International Non-Proprietary Names (INNs), Provided for Pharmaceutical Substances by the World Health Organization, Which Are Free of Duty". Official Journal of the European Communities. 23 October 2001. Archived from the original (PDF) on 27 June 2014. Retrieved 7 December 2009. Unknown parameter |url-status= ignored (help)
↑ Hrib NJ, Martin LL (1989). Chapter 2. Antianxiety Agents and Anticonvulsants. Annual Reports in Medicinal Chemistry. 24. pp. 11–20. doi:10.1016/s0065-7743(08)60524-2. ISBN 9780120405244. Search this book on
↑ Pérez C, Mondelo N, Stéfano FJ, Lores Arnaiz J (May 1988). "Pharmacological activity of novel alkylsulfonylaryl-1-substituted-1,4-benzodiazepine derivatives". Archives Internationales de Pharmacodynamie et de Therapie. 293: 57–68. PMID 2901826.

Template:Benzodiazepines Template:GABAAR PAMs

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[1] "List of International Non-Proprietary Names (INNs), Provided for Pharmaceutical Substances by the World Health Organization, Which Are Free of Duty". Official Journal of the European Communities. 23 October 2001. Archived from the original (PDF) on 27 June 2014. Retrieved 7 December 2009. Unknown parameter |url-status= ignored (help)

[2] Hrib NJ, Martin LL (1989). Chapter 2. Antianxiety Agents and Anticonvulsants. Annual Reports in Medicinal Chemistry. 24. pp. 11–20. doi:10.1016/s0065-7743(08)60524-2. ISBN 9780120405244. Search this book on

[3] Pérez C, Mondelo N, Stéfano FJ, Lores Arnaiz J (May 1988). "Pharmacological activity of novel alkylsulfonylaryl-1-substituted-1,4-benzodiazepine derivatives". Archives Internationales de Pharmacodynamie et de Therapie. 293: 57–68. PMID 2901826.

[1]

[2]

[3]

Identifiers

IUPAC name 7-chloro-5-(2-chlorophenyl)-1-[2-(4-methylphenyl)sulfonylethyl]-3H-1,4-benzodiazepin-2-one
CAS Number	86273-92-9^Y
PubChem CID	65647
ChemSpider	59084^N
UNII	98SR74X50D
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C₂₄H₂₀Cl₂N₂O₃S
Molar mass	487.40 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc2ccccc2C(=NCC1=O)c3cc(Cl)ccc3N1CCS(=O)(=O)c(cc4)ccc4C
InChI InChI=1S/C24H20Cl2N2O3S/c1-16-6-9-18(10-7-16)32(30,31)13-12-28-22-11-8-17(25)14-20(22)24(27-15-23(28)29)19-4-2-3-5-21(19)26/h2-11,14H,12-13,15H2,1H3^N Key:FFZOBTGTWSRRMB-UHFFFAOYSA-N^N
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Tolufazepam

See also

References