Transmembrane protein 236
Transmembrane protein 236 (TMEM236) is a protein that, in humans, is encoded by the transmembrane protein 236 gene.[1] TMEM128 contains 6 transmembrane domains and 1 disordered region.
Gene
The TMEM236 gene is located at 10p12.33.[2] The TMEM236 gene contains 4 exons with a length of 5515 nucleotides.[2] TMEM236 is also known by the aliases: family with sequence similarity 23, member A (FAM23A) and family with sequence similarity 23, member B (FAM23B).[1]
Transcripts
There is one known isoform of TMEM236, transmembrane protein 236 isoform X1.[1] TMEM236 isoform X1 is 289 aa [3] and is missing exon 1 of TMEM236. [1]
Protein
Transmembrane Protein 236 or TMEM236, is predicted to have a molecular weight of 39.7 kDa [4] and isoelectric point (pI) of 9.36.[5]. TMEM236 is 351 aa long and contains 6 experimentally confirmed transmembrane domains along with 1 experimentally confirmed disordered region.[2]
Structure
The secondary structure of TMEM236 contains predicted Alpha Helix regions (25.07%), Extended Strand regions (26.21%), and Random Coil regions (48.71%).[6]
The AlphaFold predicted tertiary structure of the protein shows many similarities to the predicted secondary structure.[7]
Gene level regulation
TMEM236 is most highly expressed in the small intestine, duodenum, and colon; it is also expressed in the appendix and placenta at a lesser rate. [1]
Protein level regulation
There is an experimentally confirmed N-Glycosylation site at 193-196[2]; along with predicted Casein kinase II phosphorylation, N-myristoylation, Protein kinase C phosphorylation, and Tyrosine kinase phosphorylation sites.[8]
| Modification | Location |
|---|---|
| N-Glycosylation | 193-196 |
| Casein kinase II phosphorylation | 174-177
229-232 |
| N-Myristoylation | 154-159
307-312 |
| Protein kinase C phosphorylation | 3-5
155-157 |
| Tyrosine kinase phosphorylation | 39-47 |
Homology
There are no paralogs found for TMEM236. TMEM236 was found to be conserved in fish, but not found in any reptilia, amphibia, or aves on record.[9]
Interacting Proteins
TMEM236 is suspected to interact with 10 different proteins, this information was found using the STRING program, each interaction was found via text mining.[10]
| Gene | Full name | Location |
|---|---|---|
| LRRC14B | Leucine-rich repeat-containing protein 14B | chr5:191,495-196,334 |
| OR13C8 | Olfactory receptor 13C8 | chr9:104,569,168-104,570,130 |
| IQSEC3 | IQ motif and SEC7 domain-containing protein 3 | chr12:66,767-178,455 |
| TMEM191B | Transmembrane protein 191B | chr22:18,527,802-18,530,573 |
| CALN1 | Calcium-binding protein 8 | chr7:71,779,491-72,504,279 |
| TTC9 | Tetratricopeptide repeat protein 9a | chr14:70,641,916-70,675,366 |
| MYCBP2 | E3 ubiquitin-protein ligase MYCBP2 | chr13:77,042,474-77,327,094 |
| RBMS3 | RNA-binding motif, single-stranded-
interacting protein 3 |
chr3:28,574,791-30,010,395 |
| MYO16 | Unconventional myosin-XVI | chr13:108,495,716-109,208,005 |
| C1orf115 | Chromosome 1 open reading frame 115 | chr1:220,690,363-220,699,153 |
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "TMEM236 transmembrane protein 236 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
- ↑ 2.0 2.1 2.2 2.3 "Homo sapiens transmembrane protein 236 (TMEM236), mRNA". April 2, 2023 – via NCBI Nucleotide.
- ↑ "transmembrane protein 236 isoform X1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov.
- ↑ "SAPS Results". www.ebi.ac.uk.
- ↑ "SIB Swiss Institute of Bioinformatics | Expasy". www.expasy.org.
- ↑ "[unknown]". Network Protein Sequence @nalysis.
- ↑ "AlphaFold Protein Structure Database". alphafold.ebi.ac.uk.
- ↑ "Motif Scan". myhits.sib.swiss.
- ↑ "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov.
- ↑ "[unknown]". STRING CONSORTIUM.
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