Tropogen
Tropogen is a term coined by Stanford University virologist Dr. Robert Siegel, referring to the glycoprotein on the outside of a virus that attaches to the cell receptor to facilitate entry into the cell. The specificity of the tropogen-receptor interaction determines why viruses can enter only some cells over others, and it plays a role in tissue tropism and host range interactions.
Examples
For example, hemagglutinin on the surface of the Influenza virus is an example of a tropogen, as it binds to sialic acid on the surface of host cells in order to infect the cell, usually in the respiratory tract.[1] Another example of a tropogen is the spike (S) protein of SARS-CoV-2 which binds to the Angiotensin-converting enzyme 2 or ACE2 in order to enter the cell.[2]
References
- ↑ "Influenza Hemagglutinin (HA) Protein Function". Sino Biological. Sino Biological. Retrieved 16 November 2020.
- ↑ Huang, Yuan. "Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19". Nature. Nature. PMID 32747721 Check
|pmid=value (help). Retrieved 16 November 2020.
Tropogen
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