Wisdom Panel
Wisdom Panel is a consumer pet genetics test, providing dog DNA testing services to pet owners, breeders, veterinarians, and shelters.
| Private Company | |
| ISIN | 🆔 |
| Industry | Genetic Genealogy, Biotechnology |
| Founded 📆 | 2005 |
| Founder 👔 | |
Area served 🗺️ | |
| Products 📟 | Wisdom Panel dog DNA test |
| Services | Genetic testing, genetic genealogy, clinical research |
| Members | |
Number of employees | |
| Parent | Mars Petcare |
| 🌐 Website | wisdompanel |
| 📇 Address | |
| 📞 telephone | |
History
In 2005, Mars Veterinary became a division of Mars Symbioscience based at Nottingham Laboratory. [1] In 2007, Mars Veterinary launched Wisdom Panel MX — a DNA test designed to identify the breeds in a mixed breed dog — into veterinary hospitals in the United States in 2007. [2]
In 2009, Mars Veterinary launched the Wisdom Panel Insights test into the consumer market. [3] In 2010, Mars Veterinary launched Optimal Selection, a test meant to evaluate and align potential breeding dogs based on genetic diversity. [4]
In 2013, Mars Veterinary launched Wisdom Panel 2.0 [5], followed by Wisdom Panel 3.0 — which featured testing for the multi-drug sensitivity (MDR1) mutation — in 2015. [6] Also in 2015, Mars Veterinary transitioned into the Mars Petcare segment. [7]
In early 2017, Mars Veterinary launched the Optimal Selection test for feline breeders [8] and the Wisdom Panel 4.0 test, which introduced trait analysis and screening for the exercise-induced collapse (EIC) mutation. [9] In 2017, Mars Veterinary changed its business name to “Wisdom Health,” [10] introduced the Wisdom Panel Health breed and disease test for consumers [11], and acquired Finnish research and diagnostics company, Genoscoper Laboratories. [12]
In 2018, Wisdom Panel acquired genetics research firm Optigen, LLC. [13]
Wisdom Panel's DNA database recently surpassed two million consumer dog DNA tests. [14]
Research
In October 2019, PLOS One published a study based on submissions from the Wisdom Panel veterinary science and research team in partnership with Purdue University on dog coat color genes and traits. The study referenced the DNA results database behind Wisdom Panel tests to examine physical trait variation of almost 12,000 purebred dogs from 212 breeds and four wild canine species. [15] The study found 'many dog breeds carry gene variants for unexpected physical traits such as coat colors, which could randomly appear in future generations.’ [16]
In April 2018, PLOS Genetics published a study analyzing over 100,000 mixed and purebred dogs detailing the frequency and distribution of 152 genetic disease variants across 330 breeds, types, and varieties from Wisdom Panel veterinary science researchers. The study found that while fewer mixed breed dogs are affected by the most common disease-causing mutations tested than purebred dogs, mixed-breed dogs are still at risk of genetic disorders. Additionally, the study found that two in five dogs carried at least one copy of the disease variants studied. [17] Summary statistics per breed from this paper are publicly available through MyBreedData to serve the breeder, veterinary and scientific communities.
PLOS One published a study in November 2017 describing the frequency of five inherited disease-causing mutations in mixed breed dogs, including hyperuricosuria and hyperuricemia (HUU), cystinuria (CYST), factor VII deficiency (FVIID), myotonia congenita (MYC) and phosphofructokinase deficiency (PKFD). The University of Wisconsin - River Falls Summer Scholars Program supported the study, which relied on data from Wisdom Panel tests and collaboration with the company's veterinary science researchers. [18]
In January 2014, researchers at Wisdom Panel published a study in PLOS One utilizing genome analysis to determine genes leading to hip dysplasia in Labrador Retrievers. Through a genome association study of Dutch Labrador Retrievers, the study compared data from nearly 18,000 single nucleotide polymorphisms identified genes that may cause a dog to be susceptible to hip dysplasia. [19]
Other notable studies involving Wisdom Panel
- Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication (2010)[20]
- Genetic Mapping of Fixed Phenotypes: Disease Frequency as a Breed Characteristic (2009)[21]
- Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes (2008)[22]
- Population Structure and Inbreeding From Pedigree Analysis of Purebred Dogs (2008)[23]
Licensure and Partnerships
Wisdom Panel holds the worldwide license for the genetic breed detection process pioneered by canine geneticist Dr. Elaine Ostrander during her time at the Fred Hutchinson Cancer Research Institute. [24] Additionally, Wisdom Panel holds the only commercial license in the United States for the multi-drug sensitivity (MDR1) screening from Washington State University. [25]
Wisdom Panel partners with groups such as the International Partnership for Dogs (IPFD), International Society for Animal Genetics (ISAG), Morris Animal Foundation (MAF), and Orthopedic Foundation for Animals (OFA). [26]
See also
References
- ↑ "About Wisdom Health, Makers of the Wisdom Panel Dog DNA Test - Wisdom Panel". About Wisdom Health, Makers of the Wisdom Panel Dog DNA Test - Wisdom Panel.
- ↑ "DNA Study Unlocks Mystery To Diverse Traits In Dogs". ScienceDaily. Retrieved 2019-11-15.
- ↑ "Mars Veterinary Launches DIY DNA Kit for Dog Owners | Mars Symbioscience". www.marssymbioscience.com.
- ↑ "Optimal Selection™ Canine and Feline DNA Tests". www.optimal-selection.com. Retrieved 2019-11-15.
- ↑ "NEW IMPROVED DOG DNA TEST NOW COVERS 200 BREEDS AND VARIETIES | Mars Symbioscience". www.marssymbioscience.com.
- ↑ "Mars Veterinary Release: Wisdom Panel Launches New Canine DNA Test To Reveal Potentially Life-Saving Genetic Information". BioSpace.
- ↑ "About Wisdom Health, Makers of the Wisdom Panel Dog DNA Test - Wisdom Panel". About Wisdom Health, Makers of the Wisdom Panel Dog DNA Test - Wisdom Panel.
- ↑ Staff, Pet Product News. "Mars Veterinary Offers Optimal Selection DNA Test for Feline Breeders". PetProductNews.com. zero width space character in
|title=at position 50 (help) - ↑ "Unlocking the genetic secrets of your dog". American Veterinary Medical Association.
- ↑ https://help.wisdompanel.com/s/article/Is-Wisdom-Health-the-same-as-Mars-Veterinary. Missing or empty
|title=(help) - ↑ https://help.wisdompanel.com/s/article/When-were-the-Wisdom-Panel-canine-DNA-tests-launched. Missing or empty
|title=(help) - ↑ "Mars Acquires Genoscoper for Discovery of Genetic Health Markers | Mars, Incorporated". www.mars.com.
- ↑ Petcare, Mars. "Mars Petcare Acquisition of OptiGen, LLC Will Enable Discovery of New Genetic Health Markers for Dogs". www.prnewswire.co.uk. Retrieved 2019-11-15.
- ↑ "Wisdom Health Genetics DNA Database, Powering Wisdom Panel™ Products, Surpasses Two Million Dogs Tested". www.businesswire.com. 19 August 2020.
- ↑ Dreger, Dayna L.; Hooser, Blair N.; Hughes, Angela M.; Ganesan, Balasubramanian; Donner, Jonas; Anderson, Heidi; Holtvoigt, Lauren; Ekenstedt, Kari J. (2019-10-28). "True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential". PLOS ONE. 14 (10): e0223995. Bibcode:2019PLoSO..1423995D. doi:10.1371/journal.pone.0223995. ISSN 1932-6203. PMC 6816562 Check
|pmc=value (help). PMID 31658272. - ↑ Health, Wisdom. "First-of-its-kind study reveals genetic traits determining coat colors and physical appearance in over 200 dog breeds". www.prnewswire.com. Retrieved 2019-11-14.
- ↑ Donner, Jonas; Anderson, Heidi; Davison, Stephen; Hughes, Angela M.; Bouirmane, Julia; Lindqvist, Johan; Lytle, Katherine M.; Ganesan, Balasubramanian; Ottka, Claudia; Ruotanen, Päivi; Kaukonen, Maria (2018-04-30). "Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs". PLOS Genetics. 14 (4): e1007361. doi:10.1371/journal.pgen.1007361. ISSN 1553-7404. PMC 5945203. PMID 29708978.
- ↑ Zierath, Sharon; Hughes, Angela M.; Fretwell, Neale; Dibley, Mark; Ekenstedt, Kari J. (2017-11-22). "Frequency of five disease-causing genetic mutations in a large mixed-breed dog population (2011–2012)". PLOS ONE. 12 (11): e0188543. Bibcode:2017PLoSO..1288543Z. doi:10.1371/journal.pone.0188543. ISSN 1932-6203. PMC 5699815. PMID 29166669.
- ↑ Lavrijsen, Ineke C. M.; Leegwater, Peter A. J.; Martin, Alan J.; Harris, Stephen J.; Tryfonidou, Marianna A.; Heuven, Henri C. M.; Hazewinkel, Herman A. W. (2014-01-30). "Genome Wide Analysis Indicates Genes for Basement Membrane and Cartilage Matrix Proteins as Candidates for Hip Dysplasia in Labrador Retrievers". PLOS ONE. 9 (1): e87735. Bibcode:2014PLoSO...987735L. doi:10.1371/journal.pone.0087735. ISSN 1932-6203. PMC 3907504. PMID 24498183.
- ↑ vonHoldt, Bridgett M.; Pollinger, John P.; Lohmueller, Kirk E.; Han, Eunjung; Parker, Heidi G.; Quignon, Pascale; Degenhardt, Jeremiah D.; Boyko, Adam R.; Earl, Dent A.; Auton, Adam; Reynolds, Andy (2010-04-08). "Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication". Nature. 464 (7290): 898–902. Bibcode:2010Natur.464..898V. doi:10.1038/nature08837. ISSN 0028-0836. PMC 3494089. PMID 20237475.
- ↑ Chase, Kevin; Jones, Paul; Martin, Alan; Ostrander, Elaine A.; Lark, Karl G. (2009). "Genetic Mapping of Fixed Phenotypes: Disease Frequency as a Breed Characteristic". Journal of Heredity. 100 (Suppl 1): S37–S41. doi:10.1093/jhered/esp011. ISSN 0022-1503. PMC 3139361. PMID 19321632.
- ↑ Jones, Paul; Chase, Kevin; Martin, Alan; Davern, Pluis; Ostrander, Elaine A.; Lark, Karl G. (June 2008). "Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes". Genetics. 179 (2): 1033–1044. doi:10.1534/genetics.108.087866. ISSN 0016-6731. PMC 2429857. PMID 18505865.
- ↑ Calboli, Federico C. F.; Sampson, Jeff; Fretwell, Neale; Balding, David J. (May 2008). "Population Structure and Inbreeding From Pedigree Analysis of Purebred Dogs". Genetics. 179 (1): 593–601. doi:10.1534/genetics.107.084954. ISSN 0016-6731. PMC 2390636. PMID 18493074.
- ↑ "Vancouver's Wisdom Health tests dog DNA for breed, genetic diseases". The Columbian.
- ↑ Karow, Julia (Sep 27, 2017). "Dog DNA Testing Market Grows As Vendors Target Consumers, Breeders, Vets". genomeweb.
- ↑ "Research on Canine Genetics | Wisdom Panel - Wisdom Panel". Research on Canine Genetics | Wisdom Panel - Wisdom Panel.
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