Zhongping Chen
| Zhongping Chen | |
|---|---|
| File:Zhongping Chen UCI.jpgZhongping_Chen_UCI.jpg | |
| Born | |
| 🏳️ Citizenship | American |
| 🎓 Alma mater | Shanghai Jiao Tong University; Cornell University |
| 💼 Occupation | |
| Known for | Optical Coherence Tomography, Doppler Optical Coherence Tomography |
Zhongping Chen
Zhongping Chen is a Professor of Biomedical Engineering and Director of the F-OCT Laboratory at the University of California, Irvine.[1] He is a co-founder and chairman of the board of directors of OCT Medical Imaging, Inc.
Education and Career
Dr. Chen received his B.S. degree from Shanghai Jiao Tong University and his M.S. and Ph.D. degrees from Cornell University. At UCI, he leads the Functional Optical Coherence Tomography Laboratory (F-OCT)[2], focusing on translational technologies for medical imaging and diagnosis.
Research Contributions
Zhongping Chen is a pioneering figure in biomedical optics, best known for his fundamental work in expanding the capabilities of optical coherence tomography (OCT) from purely structural imaging into functional imaging. He was among the first to publish on Doppler OCT[3] [4] [5], a technology that allows for the visualization and quantification of blood flow in microcirculation, and his group has played a leading role in developing other functional extensions including OCT angiography, optical coherence elastography[6] [7] , and second harmonic OCT, which provide critical contrast mechanisms for mapping clinically important parameters. The Doppler OCT and OCTA technologies developed by his team have been widely adopted in brain research and clinical ophthalmology[8]. His lab also designed some of the first miniaturized endoscopic and intravascular probes—including rotational and linear 2-D scanners—for OCT and fiber-based multiphoton microscopy (MPM), enabling high-resolution imaging inside the body. A key translational achievement was the development of an integrated intravascular OCT/ultrasound (US) system [9], demonstrating the first in vivo co-registered imaging with a single miniature probe. Furthermore, his group created a high-speed Fourier domain long-range OCT system for imaging the full airway in pediatric patients with obstructive sleep apnea, with studies encompassing over 400 human subjects. His work has translated these optical imaging technologies into clinical applications for diagnosing diseases in cardiology, ophthalmology, airway management, and oncology. He has authored more than 400 peer-reviewed publications and holds over 25 patents in the fields of biomaterials, biosensors, and biomedical imaging.[10]
Awards and Honors
- Fellow, Optica (formerly Optical Society of America), 2007.[11]
- Fellow, SPIE (International Society for Optics and Photonics)
- Fellow, American Institute of Medical and Biological Engineering (AIMBE)
- Michael S. Feld Biophotonics Award, 2024.[12]
References
- ↑ "Zhongping Chen – UCI Engineering Profile". University of California, Irvine. Retrieved 2025-08-28.
- ↑ "Functional OCT Laboratory (F-OCT)". University of California, Irvine. Retrieved 2025-08-28.
- ↑ Chen, Z.; Milner, T. E.; Srinivas, S.; Wang, X.; Malekafzali, A.; van Gemert, M. J.; Nelson, J. S. (1997). "Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography". Optics Letters. 22 (14): 1119–1121. Bibcode:1997OptL...22.1119C. doi:10.1364/OL.22.001119. PMID 18185770.
- ↑ Chen, Z.; Milner, T. E.; Dave, D.; Nelson, J. S. (1997). "Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media". Optics Letters. 22 (1): 64–66. Bibcode:1997OptL...22...64C. doi:10.1364/OL.22.000064. PMID 18183104.
- ↑ Zhao, Y.; Chen, Z.; Saxer, C.; Xiang, S.; de Boer, J. F.; Nelson, J. S. (2000). "Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity". Optics Letters. 25 (2): 114–116. Bibcode:2000OptL...25..114Z. doi:10.1364/OL.25.000114. PMID 18059800.
- ↑ Qi, W.; Chen, R.; Chou, L.; Liu, G.; Zhang, J.; Zhou, Q.; Chen, Z. (2012). "Phase-resolved acoustic radiation force optical coherence elastography". Journal of Biomedical Optics. 17 (11): 110505. Bibcode:2012JBO....17k0505Q. doi:10.1117/1.JBO.17.11.110505. PMC 3487536. PMID 23123971.
- ↑ Li, R.; Hua, Y.; Zhang, F.; Qian, X.; Gong, C.; Wan, X.; Zhou, Q. (2025). "Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties". Science Advances. 11 (28): eadp8631. doi:10.1126/sciadv.adp8631. PMC 12239965 Check
|pmc=value (help). PMID 40632852 Check|pmid=value (help). - ↑ Wang, J.; Ye, Q.; Chou, L.; Qiu, S.; Xu, X.; Chen, Z. (2024). "Miniaturized head-mount Doppler optical coherence tomography scope for freely moving mouse". ACS Photonics. 11 (8): 3381–3389. doi:10.1021/acsphotonics.4c00702. PMC 11342407 Check
|pmc=value (help). PMID 39184188 Check|pmid=value (help). - ↑ Yin, J.; Li, X.; Jing, J.; Li, J.; Mukai, D.; Mahon, S.; Chen, Z. (2011). "Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging". Journal of Biomedical Optics. 16 (6): 060505–060505–3. Bibcode:2011JBO....16f0505Y. doi:10.1117/1.3589097. PMC 3124531. PMID 21721799.
- ↑ "Zhongping Chen – Google Scholar". Google Scholar. Retrieved 2025-08-28.
- ↑ "2007 Optica Fellows". Optica. Retrieved 2025-08-28.
- ↑ "2024 Michael S. Feld Biophotonics Award Winner". Optica. 2024. Retrieved 2025-08-28.
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