Jieping Zhu
| Professor Jieping Zhu | |
|---|---|
| File:EPFL Zhu Jieping 2021.jpgEPFL Zhu Jieping 2021.jpg Jieping Zhu in 2021 | |
| Born | 1965 (age 60–61) Xiaoshan, Hangzhou, China |
| 🏳️ Citizenship | France |
| 💼 Occupation | |
| Known for | Total synthesis of complex natural products and bioactive compounds, development of novel multicomponent reactions, domino process and catalytic enantioselective transformation |
| 🏅 Awards | 2016 Natural Product Chemistry Award (RSC) Prix SCF-DCO Chang Jiang Scholars CNRS Silver Medal |
| 🌐 Website | https://www.epfl.ch/labs/lspn/ |
Jieping Zhu (个人简介; born 1965 in Xiaoshan, Hangzhou, China) is an organic chemist specialized in specialized in natural product total synthesis and organometallics. He is a professor of chemistry at EPFL (École Polytechnique Fédérale de Lausanne) and the head of the Laboratory of Synthesis and Natural Products.[1]
Career
Zhu studied chemistry at Hangzhou Normal University and at Lanzhou University, both in China. He then joined Henri-Philippe Husson and Jean-Charles Quirion to pursue a PhD in organic chemistry at the Institute de Chimie des Substances Naturelles at the French National Centre for Scientific Research.[2] In 1991, he graduated with a thesis on Synthèse asymétrique de dérivés de l'histrionicotoxine et de spiropipéridines apparentées (Asymmetric synthesis of histrionicotoxin derivatives and related spiropiperidines).[3]
As a postdoctoral researcher he went to work with Derek Barton at the Texas A&M University and pursue research on phosphonic acid synthesis.[4] In 1992, he joined Institut de Chimie des Substances Naturelles (ICSN) as a chargé de recherche. In 2000, he was promoted to directeur de recherche 2nd class, then 1st class in 2006 in the same institute.
Since 2010, he has been full professor of chemistry at EPFL's School of Basic Sciences of EPFL.
Research
Zhu’s research focuses on the development of new methods for the synthesis of of multicomponent reactions,[5][6][7] catalytic enantioselective transformations,[8][9][10] and transition metal catalyzed domino processes.[11][12][13] He is also immersed in the total synthesis of complex natural products and bioactive molecules.[14][15][16][17]
Distinctions
Zhu is the recipient of among others the 2016 Natural Product Chemistry Award from the Royal Society of Chemistry (RSC) Natural Product Chemistry Award,[18] the 2010 Division of Organic Chemistry (Prix SCF-DCO) award from the Société chimique de France (French Chemical Society),[19] the 2009 Chang Jiang Scholars (Qinghua University) awarded by the Chinese Ministry of Education, the 2009 Silver Medal of CNRS,[20] the 2008 Novartis Chemistry Lectureship, the 2004 Liebig Lectureship of the German Chemical Society,[21] and the 2003 Prix “Emile Jungfleisch” of French Academy of Science.[22]
He is a fellow of the Royal Society of Chemistry. He is editor at the journal Tetrahedron Letters.[23]
Selected works
Books
- Zhu, Jieping; Bienaymé, Hugues (6 March 2006). Multicomponent Reactions. ISBN 9783527604241. Search this book on
- Zhu, Jieping; Wang, Qian; Wang, Meixiang (15 October 2014). Multicomponent Reactions in Organic Synthesis. ISBN 9783527678204. Search this book on
Papers
- Zhu, Jieping (2003). "Recent Developments in the Isonitrile‐Based Multicomponent Synthesis of Heterocycles". European Journal of Organic Chemistry. 2003 (7): 1133–1144. doi:10.1002/ejoc.200390167.
- Janvier, Pierre; Sun, Xiaowen; Bienaymé, Hugues; Zhu, Jieping (2002). "Ammonium Chloride-Promoted Four-Component Synthesis of Pyrrolo[3,4-b]pyridin-5-one". Journal of the American Chemical Society. 124 (11): 2560–2567. doi:10.1021/ja017563a. PMID 11890807.
- Chen, Jinchun; Chen, Xiaochuan; Bois-Choussy, Michèle; Zhu, Jieping (2006). "Total Synthesis of Ecteinascidin 743". Journal of the American Chemical Society. 128 (1): 87–89. doi:10.1021/ja0571794. PMID 16390134.
- Xu, Zhengren; Wang, Qian; Zhu, Jieping (2015). "Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine e, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines a and C". Journal of the American Chemical Society. 137 (20): 6712–6724. doi:10.1021/jacs.5b03619. PMID 25946614.
- Andres, Rémi; Wang, Qian; Zhu, Jieping (2020). "Asymmetric Total Synthesis of (−)-Arborisidine and (−)-19-epi-Arborisidine Enabled by a Catalytic Enantioselective Pictet–Spengler Reaction". Journal of the American Chemical Society. 142 (33): 14276–14285. doi:10.1021/jacs.0c05804. PMID 32692169 Check
|pmid=value (help). - Delayre, Bastien; Piemontesi, Cyril; Wang, Qian; Zhu, Jieping (2020). "Ti Cl 3 ‐Mediated Synthesis of 2,3,3‐Trisubstituted Indolenines: Total Synthesis of (+)‐1,2‐Dehydroaspidospermidine, (+)‐Condyfoline, and (−)‐Tubifoline". Angewandte Chemie International Edition. 59 (33): 13990–13997. doi:10.1002/anie.202005380. PMID 32415682 Check
|pmid=value (help).
References
- ↑ "LSPN". www.epfl.ch. Retrieved 2021-04-13.
- ↑ Zhu, Jieping; Quirion, Jean Charles; Husson, Henri Philippe (1993-11-XX). "Asymmetric synthesis. 29. Preparation of 1,8-diazaspiro[5.5]undecane derivatives". The Journal of Organic Chemistry. 58 (23): 6451–6456. doi:10.1021/jo00075a048. ISSN 0022-3263. Check date values in:
|date=(help) - ↑ Zhu, Jieping; Husson, Henri-Philippe (1991). Synthèse asymétrique de dérivés de l'histrionicotoxine et de spiropipéridines apparentées. Search this book on
- ↑ Barton, Derek H. R.; Zhu, Jieping (1993-03-XX). "Elemental white phosphorus as a radical trap: a new and general route to phosphonic acids". Journal of the American Chemical Society. 115 (5): 2071–2072. doi:10.1021/ja00058a082. ISSN 0002-7863. Check date values in:
|date=(help) - ↑ Bao, Xu; Yokoe, Takayuki; Ha, Tu M.; Wang, Qian; Zhu, Jieping (2018-09-13). "Copper-catalyzed methylative difunctionalization of alkenes". Nature Communications. 9 (1): 3725. Bibcode:2018NatCo...9.3725B. doi:10.1038/s41467-018-06246-6. ISSN 2041-1723. Unknown parameter
|s2cid=ignored (help) - ↑ Tong, Shuo; Piemontesi, Cyril; Wang, Qian; Wang, Mei-Xiang; Zhu, Jieping (2017). "Silver-Catalyzed Three-Component 1,1-Aminoacylation of Homopropargylamines: α-Additions for Both Terminal Alkynes and Isocyanides". Angewandte Chemie International Edition. 56 (27): 7958–7962. doi:10.1002/anie.201704727. ISSN 1521-3773. PMID 28493495.
- ↑ Bunescu, Ala; Ha, Tu M.; Wang, Qian; Zhu, Jieping (2017-08-21). "Copper-Catalyzed Three-Component Carboazidation of Alkenes with Acetonitrile and Sodium Azide". Angewandte Chemie. 129 (35): 10691–10694. doi:10.1002/ange.201705353.
- ↑ Zheng, Sheng-Cai; Wang, Qian; Zhu, Jieping (2019). "Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles". Angewandte Chemie International Edition. 58 (5): 1494–1498. doi:10.1002/anie.201812654. ISSN 1521-3773. PMID 30480863.
- ↑ Kong, Wangqing; Wang, Qian; Zhu, Jieping (2015-12-30). "Palladium-Catalyzed Enantioselective Domino Heck/Intermolecular C–H Bond Functionalization: Development and Application to the Synthesis of (+)-Esermethole". Journal of the American Chemical Society. 137 (51): 16028–16031. doi:10.1021/jacs.5b11625. ISSN 0002-7863. PMID 26681502.
- ↑ Wu, Hua; Wang, Qian; Zhu, Jieping (2019-07-24). "Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters". Journal of the American Chemical Society. 141 (29): 11372–11377. doi:10.1021/jacs.9b04551. ISSN 0002-7863. PMID 31282151.
- ↑ Budai, Balázs; Leclair, Alexandre; Wang, Qian; Zhu, Jieping (2019-07-22). "Copper‐Catalyzed 1,2‐Methoxy Methoxycarbonylation of Alkenes with Methyl Formate". Angewandte Chemie. 131 (30): 10411–10415. doi:10.1002/ange.201904263. ISSN 0044-8249.
- ↑ Piou, Tiffany; Bunescu, Ala; Wang, Qian; Neuville, Luc; Zhu, Jieping (2013). "Palladium‐Catalyzed Through‐Space C(sp3)–H and C(sp2)–H Bond Activation by 1,4‐Palladium Migration: Efficient Synthesis of [3,4]‐Fused Oxindoles". Angewandte Chemie International Edition. 52 (47): 12385–12389. doi:10.1002/anie.201306532. ISSN 1521-3773. PMID 24105995.
- ↑ Bao, Xu; Wang, Qian; Zhu, Jieping (2019-02-11). "Dual Photoredox/Copper Catalysis for the Remote C(sp 3 )−H Functionalization of Alcohols and Alkyl Halides by N -Alkoxypyridinium Salts". Angewandte Chemie International Edition. 58 (7): 2139–2143. doi:10.1002/anie.201813356. PMID 30589177.
- ↑ Li, Guang; Piemontesi, Cyril; Wang, Qian; Zhu, Jieping (2019-02-25). "Stereoselective Total Synthesis of Eburnane‐Type Alkaloids Enabled by Conformation‐Directed Cyclization and Rearrangement". Angewandte Chemie International Edition. 58 (9): 2870–2874. doi:10.1002/anie.201813920. ISSN 1433-7851. PMID 30600890.
- ↑ Torres-Ochoa, Rubén O.; Buyck, Thomas; Wang, Qian; Zhu, Jieping (2018-05-14). "Heteroannulation of Arynes with α-Amino Imides: Synthesis of 2,2-Disubstituted Indolin-3-ones and Application to the Enantioselective Total Synthesis of (+)-Hinckdentine A". Angewandte Chemie International Edition. 57 (20): 5679–5683. doi:10.1002/anie.201800746. PMID 29600593.
- ↑ Piemontesi, Cyril; Wang, Qian; Zhu, Jieping (2016-09-07). "Enantioselective Synthesis of (+)-Peganumine A". Journal of the American Chemical Society. 138 (35): 11148–11151. doi:10.1021/jacs.6b07846. ISSN 0002-7863. PMID 27558528.
- ↑ "Research". www.epfl.ch. Retrieved 2021-04-14.
- ↑ "Royal Society of Chemistry Prizes and Awards 2016". Angewandte Chemie International Edition. 55 (35): 10181–10182. 2016. doi:10.1002/anie.201605977. ISSN 1521-3773.
- ↑ "Lauréats - Société Chimique de France". www.societechimiquedefrance.fr. Retrieved 2021-04-14.
- ↑ "Jieping Zhu | CNRS". www.cnrs.fr. Retrieved 2021-04-14.
- ↑ "Liebig-Lectureship | Gesellschaft Deutscher Chemiker e.V." www.gdch.de (in Deutsch). Retrieved 2021-04-14.
- ↑ "Jieping Zhu". Angewandte Chemie International Edition. 52 (27): 6812–6813. 2013. doi:10.1002/anie.201210061. ISSN 1521-3773.
- ↑ "Professor Jieping Zhu". Elsevier. Retrieved 2021-04-14. Unknown parameter
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External links
- Zhu Jieping publications indexed by Google Scholar
- Website of the Laboratory of Synthesis and Natural Products
Category:1965 births Category:Living people Category:Hangzhou Normal University alumni Category:Lanzhou University alumni Category:École Polytechnique Fédérale de Lausanne faculty Category:Chemists
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