Welcome to EverybodyWiki 😃 ! Nuvola apps kgpg.png Log in or ➕👤 create an account to improve, watchlist or create an article like a 🏭 company page or a 👨👩 bio (yours ?)...

Zorecimeran

From EverybodyWiki Bios & Wiki




Zorecimeran
Vaccine description
Target diseaseCOVID-19
TypemRNA
Clinical data
SynonymsCVnCoV
Routes of
administration
Intramuscular
Identifiers
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}

Zorecimeran, also known as CVnCoV is a COVID-19 vaccine candidate developed by CureVac and Coalition for Epidemic Preparedness Innovations (CEPI).

Description[edit]

Zorecimeran is an mRNA technology programmed with information about the coronavirus protein as an unknown pathogen, and activates the immune system against it.[1] As an mRNA vaccine, zorecimeran has established safety, and provides a minimal, harmless piece of the coronavirus spike protein to initiate an immune response against COVID-19 disease.[1][2] Zorecimeran technology does not interact with the human genome.[1]

Clinical trial progress[edit]

Phase I-II[edit]

In November 2020, CureVac reported results of a Phase I-II clinical trial that zorecimeran (CVnCoV) was well-tolerated, safe, and produced a robust immune response.[3][4]

Phase III[edit]

In December, CureVac began a Phase III clinical trial of zorecimeran with 36,500 participants.[5][6][6] Bayer will provide clinical trial support and international logistics for the Phase III trial, and may be involved in eventual manufacturing should the vaccine prove to be safe and effective.[7]

Manufacturing[edit]

Manufacturing of mRNA vaccines can be performed rapidly in high volume,[8] including use of portable, automated printers ("RNA microfactories") for which CureVac has a joint development partnership with Tesla.[9]

Cold chain[edit]

mRNA vaccines require stringent cold chain refrigeration throughout manufacturing, distribution and storage.[10][11] The CureVac technology for zorecimeran uses a non-modified, more natural mRNA less affected by hydrolysis, enabling storage at 5 °C (41 °F) and relatively simplified cold chain requirements that facilitate up to three months of storage and distribution to world regions that do not have specialized ultracold equipment.[1][8]

Preorders[edit]

CureVac has a European-based network to accelerate manufacturing of zorecimeran, if proven safe and effective, for production of up to 300 million doses in 2021 and 600 million doses in 2022.[8][12] An estimated 405 million doses will be provided to EU states.[12]

References[edit]

  1. 1.0 1.1 1.2 1.3 Schlake, Thomas; Thess, Andreas; Fotin-Mleczek, Mariola; Kallen, Karl-Josef (2012). "Developing mRNA-vaccine technologies". RNA Biology. 9 (11): 1319–1330. doi:10.4161/rna.22269. ISSN 1547-6286. PMC 3597572. PMID 23064118.
  2. "Understanding mRNA COVID-19 vaccines". US Centers for Disease Control and Prevention. 18 December 2020. Retrieved 5 January 2021.
  3. "CureVac's Covid-19 vaccine induces immune response in study". Clinical Trials Arena. 3 November 2020. Retrieved 5 January 2021.
  4. "CureVac's COVID-19 vaccine triggers immune response in Phase I trial". Reuters. 2 November 2020. Retrieved 5 January 2021.
  5. "Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older". EU Clinical Trials Register. 19 November 2020. Retrieved 5 January 2021. Proposed INN: "Zorecimeran"
  6. 6.0 6.1 "A Study to Determine the Safety and Efficacy of SARS-CoV-2 mRNA Vaccine CVnCoV in Adults". ClinicalTrials.gov. 8 December 2020. NCT04652102. Retrieved 19 December 2020.
  7. Ludwig Burger (6 January 2021). "CureVac strikes COVID-19 vaccine alliance with Bayer". Reuters. Retrieved 7 January 2021.
  8. 8.0 8.1 8.2 Allie Nawrat (3 December 2020). "Q&A with CureVac: resolving the ultra-cold chain logistics of Covid-19 mRNA vaccines". Pharmaceutical Technology. Retrieved 5 January 2021.
  9. "Tesla to make molecule printers for German COVID-19 vaccine developer CureVac". Reuters. 2 July 2020. Retrieved 19 December 2020.
  10. Kartoglu, Umit; Milstien, Julie (28 May 2014). "Tools and approaches to ensure quality of vaccines throughout the cold chain". Expert Review of Vaccines. 13 (7): 843–54. doi:10.1586/14760584.2014.923761. ISSN 1476-0584. PMC 4743593. PMID 24865112.
  11. Hanson, Celina M.; George, Anupa M.; Sawadogo, Adama; Schreiber, Benjamin (19 April 2017). "Is freezing in the vaccine cold chain an ongoing issue? A literature review". Vaccine. 35 (17): 2127–33. doi:10.1016/j.vaccine.2016.09.070. ISSN 0264-410X. PMID 28364920.
  12. 12.0 12.1 Fraiser Kansteiner (17 November 2020). "CureVac, armed with COVID-19 vaccine deal, plots 'pandemic-scale' Euro manufacturing expansion". FiercePharma, Questex LLC. Retrieved 5 January 2021.

External links[edit]


Others articles of the Topics Medicine AND Viruses  : List of healthcare systems forced to ration care for COVID-19 patients during the COVID-19 pandemic, COVID-19 pandemic deaths in April 2021, COVID-19 pandemic deaths in February 2021, COVID-19 pandemic deaths in May 2021, List of deaths due to COVID-19, COVID-19 pandemic deaths in January 2021, COVID-19 pandemic deaths in June 2020

Others articles of the Topics Viruses AND Coronavirus disease 2019 : List of SARS outbreaks, List of deaths due to COVID-19, ZyCoV-D, PTX-COVID19-B, List of healthcare systems forced to ration care for COVID-19 patients during the COVID-19 pandemic, ARCT-021, CoviVac

Others articles of the Topics Medicine AND Coronavirus disease 2019 : List of cancellations, closures and postponements in California during the 2020 coronavirus pandemic, CoviVac, ZyCoV-D, TrumpVirus, COVID-19 pandemic in the Commonwealth of Independent States, PTX-COVID19-B, List of deaths due to COVID-19

Others articles of the Topic Medicine  : Oxygen therapy, List of Indonesian people with COVID-19, COVID-19 pandemic deaths in August 2021, COVID-19 pandemic deaths in May 2020, COVID-19 pandemic deaths in November 2020, List of SARS outbreaks, Paul McMillian Davis Jr.

Others articles of the Topic Viruses  : COVID-19 pandemic deaths in April 2021, List of deaths due to COVID-19, COVID-19 pandemic deaths in August 2020, COVID-19 pandemic deaths in April 2020, COVID-19 pandemic deaths in June 2020, Coronavirus, ARCT-021

Others articles of the Topic Coronavirus disease 2019 : CoviVac, List of healthcare workers who died during COVID-19 pandemic, ZyCoV-D, PTX-COVID19-B, COVID-19 pandemic in the Commonwealth of Independent States, Impact of the COVID-19 pandemic on Universal Pictures, West Bengal COVID-19


This article "Zorecimeran" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Zorecimeran. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.