Albert Cardona
| Albert Cardona | |
|---|---|
| Born | |
| 💼 Occupation | |
| 👩 Spouse(s) | Marta Zlatic |
| 🌐 Website | Personal website Lab website |
Albert Cardona is a neuroscientist and connectomics researcher who is a Programme Leader at the MRC Laboratory of Molecular Biology and a Professor at the University of Cambridge in Cambridge, UK. His research focuses on understanding neural circuit structure and function, particularly in small animals such as the Drosophila, through the development of computational methods for large-scale neural reconstruction and the mapping of complete brain connectomes at synaptic resolution.
Education and career
Cardona completed his PhD at the University of Barcelona (2000–2005), where he studied developmental biology. He then undertook postdoctoral research on Drosophila neuroanatomy at UCLA (2005–2008) under Volker Hartenstein.
Between 2008 and 2011, Cardona was a Group Leader at the Institute of Neuroinformatics, jointly run by the University of Zurich and ETH Zurich. During this period, he developed computational and image-processing methods for neural circuit reconstruction and co-founded two influential open-source platforms that have become widely adopted in the neuroscience community.
Cardona joined the Howard Hughes Medical Institute (HHMI) Janelia Research Campus in 2012, serving as Group Leader until 2019.[1] In 2019, he was appointed Programme Leader at the MRC Laboratory of Molecular Biology and Professor at the University of Cambridge, where he leads research on whole-brain connectomics, circuit development, and structure–function relationships in neural systems.
Research contributions
Open-source software development
Cardona co-founded FIJI (Fiji Is Just ImageJ), an open-source platform for biological image analysis that has been adopted by thousands of research laboratories worldwide.[2] The platform extends ImageJ with features specifically designed for analyzing large biological datasets.
He also co-founded CATMAID (Collaborative Annotation Toolkit for Massive Amounts of Image Data), a web-based platform that enables distributed teams of researchers to collaboratively reconstruct neural circuits from electron microscopy data.[3]
Insect brain connectome
Cardona is a co-senior author of the first complete synaptic-resolution connectome of an insect brain, published in Science in 2023.[4] This work mapped approximately 3,000 neurons and 548,000 synapses in the Drosophila larva brain, representing a significant milestone in connectomics. The reconstruction involved an international collaboration spanning multiple years and required the development of new computational methods for handling and analyzing the large-scale electron microscopy datasets.
Cardona's laboratory has used these connectome datasets to investigate the neural basis of learning, sensory processing, and motor control in Drosophila, combining anatomical reconstructions with functional studies to understand how circuit structure relates to behavior.
References
- ↑ "Albert Cardona – Former Janelia Group Leader". HHMI Janelia Research Campus. Retrieved 2026-01-12.
- ↑ Schindelin, Johannes; Arganda-Carreras, Ignacio; Frise, Elke; Kaynig, Verena; Longair, Mark; Pietzsch, Thomas; Preibisch, Stephan; Rueden, Curtis; Saalfeld, Stephan; Schmid, Bernd; Tinevez, Jean-Yves; White, Daniel J.; Hartenstein, Volker; Eliceiri, Kevin; Tomancak, Pavel; Cardona, Albert (2012). "Fiji: an open-source platform for biological-image analysis". Nature Methods. 9 (7): 676–682. Bibcode:2012NatCB...9..676S. doi:10.1038/nmeth.2019. PMC 3855844.
- ↑ Saalfeld, Stephan; Cardona, Albert; Hartenstein, Volker; Tomancak, Pavel (2009). "CATMAID: collaborative annotation toolkit for massive amounts of image data". Bioinformatics. 25 (15): 1984–1986. doi:10.1093/bioinformatics/btp266. PMC 2712332. PMID 19376822.
- ↑ Winding, Michael; Pedigo, Brian D.; Barnes, Chris L.; Patsolic, Hannah G.; Park, Yongsoo; Kazimiers, Thomas; Fushiki, Akinao; Andrade, Inês V.; Khandelwal, Avinash; Valdes-Aleman, Javier; Li, Feng; Randel, Nadine; Barsotti, Elizabeth; Correia, Ana; Fetter, Richard D.; Hartenstein, Volker; Priebe, Carey E.; Vogelstein, Joshua T.; Cardona, Albert; Zlatić, Marta (2023). "The connectome of an insect brain". Science. 379 (6636): eadd9330. Bibcode:2023Sci...379d9330W. doi:10.1126/science.add9330. PMC 7614541 Check
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External links
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