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Ali Yetisen

From EverybodyWiki Bios & Wiki


Ali Yetisen
Ali Kemal Yetisen Profile Picture.jpg Ali Kemal Yetisen Profile Picture.jpg
Ali Kemal Yetisen
Born
🏳️ CitizenshipBritish
🎓 Alma mater
💼 Occupation
👔 EmployerImperial College London
🏢 Organization
Known for
Notable work
  • Holographic Point-of-Care Diagnostic Devices ( 2014 thesis)
  • The Entrepreneurial Self (2023 thesis)
🏅 Awards
  • Fellow of the Royal Society of Chemistry (2021)
  • Fellow of the Institute of Physics (2022)
  • Fellow of the IET (2022)
  • Fellow of the IChemE (2022)
  • Fellow of the IOM3 (2022)
🌐 WebsiteImperial College profile

Ali K. Yetisen is an associate professor in the Department of Chemical Engineering at Imperial College London.[1]

Education

Yetisen received his bachelor's degree in mechanical engineering as an Ann and Norman Hilberry Scholar from the University of Arizona in 2010.[2] While at Arizona, he worked on the development of microsystem-based assays and an automated tissue diagnostics system in collaboration with Roche Diagnostics.[3]

He completed his PhD in chemical engineering and biotechnology at the University of Cambridge in 2014.[4]His doctoral dissertation, titled Holographic Point-of-Care Diagnostic Devices, was supervised by Professor Chris Lowe.[5] During this period, he collaborated with clinicians at the Wolfson Diabetes and Endocrine Clinic at Addenbrooke's Hospital to support the clinical testing of biosensing technologies.[6]

From 2015 to 2017, he was a Tosteson Fellow at Harvard University and the Wellman Center for Photomedicine at Massachusetts General Hospital under the supervision of Seok-Hyun "Andy" Yun.[7] His postdoctoral work focused on the development of optical biosensors for point-of-care diagnostics.[8]

In 2023, he earned a Master of Education (M.Ed.) from Imperial College London. His dissertation focused on entrepreneurial identity development among faculty members in a STEM higher education institution.[9]

Areas of Research

Optical Biosensors

Ali K. Yetisen has contributed to developing biosensing technologies for real-time monitoring of biomarkers in bodily fluids.[10] His research spans photonic crystal biosensors, wearable diagnostics, implantable optical fibre systems, and smartphone-integrated spectroscopy platforms.[11]

Yetisen developed pulse laser writing techniques for one-dimensional (1D) photonic crystal biosensors using photopolymer materials and interference lithography.[12]

These devices exploit Bragg diffraction to detect biomolecular changes through shifts in refractive index.[13] His work demonstrated doubly photopolymerized holographic sensors for continuous biological monitoring of biomarkers.[14]

Yetisen has contributed to developing soft polymer optical fibre sensors functionalized with fluorescent probes for real-time monitoring of biomarkers.[15]

His team has further developed optical fibre bundle sensors for multiplexed detection of biomarkers in cerebrospinal fluid.[16] Yetisen collaborated with Roche Diagnostics to develop a cell staining technology for automated and an in situ hybridisation slide staining system.[17] His other contributions to the field of biosensors include fluorescent microneedle arrays for glucose monitoring,[18] and colourimetric orthodontic ligatures and lipstick for non-invasive salivary biomarker detection.[19]

Microfluidics

Yetisen used microfluidic contact lens sensors incorporating in situ microchannels for the collection and analysis of tear fluid.[20] These devices allow real-time monitoring of biomarkers in tear fluid, including inflammation markers and oxidative stress indicators.[21] He has further explored the application of contact lenses for UV detection.[22]

Yetisen has made contributions to paper-based microfluidics and lateral-flow assay development for detecting metabolic biomarkers, diseases and disorders.[23] His translational work includes the development of a hydrogel-based embolic agent commercialised by Obsidio, Inc., later acquired by Boston Scientific in 2022.[24]

Nanophotonics

Ali K. Yetisen has contributed to developing optical structures and materials for sensing, data storage, and imaging applications. His early research examined the mechanism of multiple grating formation in high-energy holographic sensors.[25] He later developed a method for reconfigurable optical assembly of nanostructures using light-induced forces.[26]

Further work introduced rewritable three-dimensional holographic data storage systems based on optical forces.[27] Yetisen also contributed to fabricating colour-selective 2.5D holograms on flexible substrates, integrating angular multiplexing and spatial encoding for chemical sensing and security applications.[28]

He developed printable surface holograms through holographic laser ablation on flexible polymers,[29] printable nanophotonic devices,[30] and printable ink-based holograms.[31] His research on carbon nanotube-based biconvex microcavities enabled advanced light focusing and wavelength control.[32]

In optical imaging, Yetisen contributed to developing multispectral microscopic multiplexed (3M) imaging platforms using deep learning to classify atomically thin crystals.[33] His work on single-shot high-throughput phase imaging employed multibeam array interferometric microscopy.[34]

He contributed to creating 3D deep learning models for atomic-layer mapping of two-dimensional materials[33] and methods to compensate for low-pass filtering effects in digital holographic microscopy.[35]

Additional contributions include the development of line-scan hyperspectral imaging microscopy with linear unmixing for automated 2D crystal identification[36] and microscale spectroscopic mapping of two-dimensional optical materials.[37]

Artistic Applications of Nanotechnology and Biotechnology

In collaboration with Katia Vega, Pattie Maes and Joseph A. Paradiso from MIT Media Lab, Yetisen has developed the first dermal biosensors to monitor biomarkers in interstitial fluid, as part of the Dermal Abyss project.[38] This interdisciplinary initiative combined biotechnology, data visualisation, and speculative interface design to explore the body as an interactive medium.[39] His biosensor research enabled the development of dermal devices for continuously tracking metabolites such as pH, proteins, electrolytes, and glucose concentrations.[40] These biosensors use colourimetric or fluorescence signals for long-term, continuous physiological tracking, enabling continuous monitoring without electronics.[41]

His work on biological media in art investigates using genetically modified tissues, bioluminescent bacteria, and living scaffolds in conceptual and installation art.[42]

Engagement and Recognition

Yetisen is an Associate Editor of the Royal Society of Chemistry's Sensors & Diagnostics and Aggregate (Wiley), and serves on the editorial boards of Biosensors and, npj Biosensing, and Advanced Sensor and Energy Materials.[43][44]

References

  1. ↑ "Imperial College Profile". Imperial College London. Archived from the original on 9 December 2024. Retrieved 5 August 2025. Unknown parameter |url-status= ignored (help)
  2. ↑ "Prof. Ali Yetisen". Humboldt University of Berlin. Retrieved 5 August 2025.
  3. ↑ Yetisen, A K; Jiang; Cooper; Qin; Palanivelu; Zohar (2011). "A microsystem-based assay for studying pollen tube guidance in plant reproduction". Journal of Micromechanics and Microengineering. 21 (5). Bibcode:2011JMiMi..21e4018Y. doi:10.1088/0960-1317/21/5/054018. Archived from the original on 18 November 2023. Retrieved 5 August 2025. Unknown parameter |url-status= ignored (help)
  4. ↑ Yetisen, Ali (2015). Holographic Sensors. Springer Theses. doi:10.1007/978-3-319-13584-7. ISBN 978-3-319-13583-0. Retrieved 5 August 2025. Search this book on
  5. ↑ Yetisen, Ali (12 February 2015). Holographic Point-of-Care Diagnostic Devices. University of Cambridge (Thesis). doi:10.17863/CAM.16078. ISBN 978-3-319-13583-0. Retrieved 5 August 2025.
  6. ↑ Yetisen, Ali K.; Montelongo, Yunuen; Da Cruz Vasconcellos, Fernando; Martinez-Hurtado, J.L.; Neupane, Sankalpa; Butt, Haider; Qasim, Malik M.; Blyth, Jeffrey; Burling, Keith; Carmody, J. Bryan; Evans, Mark; Wilkinson, Timothy D.; Kubota, Lauro T.; Monteiro, Michael J.; Lowe, Christopher R. (2014). "Reusable, Robust, and Accurate Laser-Generated Photonic Nanosensor". Nano Letters. 14 (6): 3587–3593. Bibcode:2014NanoL..14.3587Y. doi:10.1021/nl5012504. PMID 24844116 – via American Chemical Society.
  7. ↑ "FY2015 Tosteson and FMD Winners". Massachusetts General Hospital. Archived from the original on 8 July 2025. Retrieved 5 August 2025. Unknown parameter |url-status= ignored (help)
  8. ↑ Yetisen, Ali K.; Jiang, Nan; Tamayol, Ali; Ruiz-Esparza, Guillermo U.; Zhang, Yu Shrike; Medina-Pando, Sofía; Gupta, Aditi; Wolffsohn, James S.; Butt, Haider; Khademhosseini, Ali; Yun, Seok-Hyun (2017). "Paper-based microfluidic system for tear electrolyte analysis". Royal Society of Chemistry. 17 (6): 1137–1148. doi:10.1039/C6LC01450J. PMC 5433427. PMID 28207920.
  9. ↑ Yetisen, Ali (2 May 2025). The Entrepreneurial Self: Exploring the Roles of Culture and Identity Development in Nurturing Entrepreneurialism in a STEM Higher Education Institution (Thesis). Imperial College London. Retrieved 5 August 2025.
  10. ↑ "Holographic diagnostics developed to monitor medical conditions". Univarsity of Cambridge. 23 January 2014. Archived from the original on 13 February 2025. Retrieved 5 August 2025. Unknown parameter |url-status= ignored (help)
  11. ↑ Butt, Haider (11 June 2018). "Wearables in Medicine". Advanced Materials. 30 (33). Bibcode:2018AdM....3006910Y. doi:10.1002/adma.201706910. PMC 6541866 Check |pmc= value (help). PMID 29893068. Unknown parameter |article-number= ignored (help)
  12. ↑ Yetisen, Ali K.; Butt, Haider; Da Cruz Vasconcellos, Fernando; Montelongo, Yunuen; Davidson, Colin A. B.; Blyth, Jeff; Chan, Leon; Carmody, J. Bryan; Vignolini, Silvia; Steiner, Ullrich; Baumberg, Jeremy J.; Wilkinson, Timothy D.; Lowe, Christopher R. (2 January 2014). "Light-Directed Writing of Chemically Tunable Narrow-Band Holographic Sensors". Advanced Optical Materials. 2 (3): 250–254. doi:10.1002/adom.201300375 – via Wiley (publisher).
  13. ↑ Pleasants, Simon (31 July 2014). "Photonic sugar detector". Nature Photonics. 8 (585): 585. doi:10.1038/nphoton.2014.182. Archived from the original on 17 April 2025. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  14. ↑ Davies, Samuel (21 February 2023). "Reusable Dual-Photopolymerized Holographic Glucose Sensors". Advanced Functional Materials. 33 (18). doi:10.1002/adfm.202214197. Archived from the original on 11 July 2025. Retrieved 1 September 2025 – via Wiley (publisher). Unknown parameter |url-status= ignored (help); Unknown parameter |article-number= ignored (help)
  15. ↑ Yetisen, Ali K.; Jiang, Nan; Fallahi, Afsoon; Montelongo, Yunuen; Ruiz-Esparza, Guillermo U.; Tamayol, Ali; Zhang, Yu Shrike; Mahmood, Iram; Yang, Su-A; Kim, Ki Su; Butt, Haider; Khademhosseini, Ali; Yun, Seok-Hyun (13 February 2017). "Glucose-Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid". Advanced Materials. 29 (15). Bibcode:2017AdM....2906380Y. doi:10.1002/adma.201606380. PMC 5921932. PMID 28195436. Unknown parameter |article-number= ignored (help)
  16. ↑ Zhang, Yuqian; Hu, Yubing; Liu, Qiao; Lou, Kai; Wang, Shuhan; Zhang, Naihan; Jiang, Nan; Yetisen, Ali K. (2 November 2022). "Multiplexed optical fiber sensors for dynamic brain monitoring". Matte. 5 (11): 3947–3976. doi:10.1016/j.matt.2022.07.024. Archived from the original on 7 November 2022. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  17. ↑ "WO2011139976 - Cell Staining With Air Quenched Steam Heating". WIPO Patentscope. Archived from the original on 11 August 2024. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  18. ↑ Hu, Y.; Pan, Z.; De Bock, M.; Tan, T. X.; Wang, Y.; Shi, Y.; Yan, N.; Yetisen, A. K. (2024). "S0956566324005475". Biosensors and Bioelectronic. 262. doi:10.1016/j.bios.2024.116542. PMID 38991372 Check |pmid= value (help). Retrieved 1 September 2025.
  19. ↑ Yetisen, A. K. (2024). "Virtual Science Laboratories in Biochemical Engineering". SocArXiv. doi:10.31235/osf.io/425pt. Retrieved 1 September 2025 – via OSF Preprints.
  20. ↑ Jiang, Nan; Montelongo, Yunuen; Butt, Haider; Yetisen, Ali K. (2018). "Microfluidic Contact Lenses". Small. 14 (15). Bibcode:2018Small..1404363J. doi:10.1002/smll.201704363. PMC 6607692 Check |pmc= value (help). PMID 29521022. Retrieved 1 September 2025. Unknown parameter |article-number= ignored (help)
  21. ↑ Moreddu, Rosalia; Wolffsohn, James S.; Vigolo, Daniele; Yetisen, Ali K. (2020). "Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid". Sensors and Actuators B: Chemica. 317. Bibcode:2020SeAcB.31728183M. doi:10.1016/j.snb.2020.128183. Archived from the original on 12 April 2024. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help); Unknown parameter |article-number= ignored (help)
  22. ↑ Kurz, Wolfgang; Yetisen, Ali K.; Kaito, Mihai Valer; Fuchter, Matthew J.; Jakobi, Martin; Elsner, Martin; Koch, Alexander W. (2020). "UV-Sensitive Wearable Devices for Colorimetric Monitoring of UV Exposure". Advanced Optical Materials. 8 (6). doi:10.1002/adom.201901969. Retrieved 1 September 2025. Unknown parameter |article-number= ignored (help)
  23. ↑ Jiang, Nan; Ahmed, Rajib; Damayantharan, Mylon; Ünal, Barış; Butt, Haider; Yetisen, Ali K. (2019). "Lateral and Vertical Flow Assays for Point-of-Care Diagnostics". Advanced Healthcare Materials. 8 (14). doi:10.1002/adhm.201900244. PMID 31081270. Retrieved 1 September 2025. Unknown parameter |article-number= ignored (help)
  24. ↑ "Boston Scientific Announces Acquisition of Obsidio, Inc". news.bostonscientific.com. 15 August 2022. Archived from the original on 25 June 2025. Retrieved 1 September 2025.
  25. ↑ Yetisen, Ali K.; Montelongo, Yunuen; Farandos, Nicholas M.; Naydenova, Izabela; Lowe, Christopher R.; Yun, Seok Hyun (31 December 2014). "Mechanism of Multiple Grating Formation in High". Applied Physics Letters. 105 (26). doi:10.1063/1.4905352. Archived from the original on 14 August 2024. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  26. ↑ Montelongo, Yunuen; Yetisen, Ali K.; Butt, Haider; Yun, Seok-Hyun (23 June 2016). "Reconfigurable optical assembly of nanostructures". Nature Communications. 7 (1). Bibcode:2016NatCo...712002M. doi:10.1038/ncomms12002. PMC 4931027. PMID 27337216. Unknown parameter |article-number= ignored (help)
  27. ↑ Yetisen, Ali K.; Montelongo, Yunuen; Butt, Haider (10 August 2016). "Rewritable Three Dimensional Holographic Data". Applied Physics Letters. 109 (6). doi:10.1063/1.4960710. Archived from the original on 7 February 2025. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  28. ↑ Yetisen, A.K.; Butt, H.; Mikulchyk, T.; Ahmed, R.; Montelongo, Y.; Humar, M.; Jiang, N.; Martin, S.; Naydenova, I.; Yun, S.H. (2016). "Color-Selective 2.5D Holograms on Large-Area Flexible Substrates for Sensing and Multilevel Security". Advanced Optical Materials. 4 (10): 1589–1600. doi:10.1002/adom.201600162.
  29. ↑ Vasconcellos, Fernando da Cruz; Yetisen, Ali K.; Montelongo, Yunuen; Butt, Haider; Grigore, Alexandra; Davidson, Colin A. B.; Blyth, Jeff; Monteiro, Michael J.; Wilkinson, Timothy D.; Lowe, Christopher R. (2014). "Printable Surface Holograms via Laser Ablation". ACS Phonetics. 1 (6): 489–495. Bibcode:2014ACSP....1..489V. doi:10.1021/ph400149m. Archived from the original on 16 November 2023. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  30. ↑ Zhao, Q.; Yetisen, A. K.; Sabouri, A.; Yun, S. H.; Butt, H. (2015). "Color-Selective 2.5D Holograms on Large-Area Flexible Substrates for Sensing and Multilevel Security". ACS Nano. 9 (9): 9062–9069. doi:10.1021/acsnano.5b03165. PMID 26301907. Archived from the original on 6 December 2023. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  31. ↑ Zhao, Qiancheng; Yetisen, Ali K.; Anthony, Carl J.; Fowler, William R.; Yun, Seok Hyun; Butt, Haider (2015). "Printable Ink Holograms". Applied Physics Letters. 107 (4). Bibcode:2015ApPhL.107d1115Z. doi:10.1063/1.4928046. Archived from the original on 16 November 2023. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help); Unknown parameter |article-number= ignored (help)
  32. ↑ Butt, Haider; Yetisen, Ali K.; Ahmed, Rajib; Yun, Seok Hyun; Dai, Qing (2015). "Carbon Nanotube Biconvex Microcavities". Applied Physics Letters. 106 (12). Bibcode:2015ApPhL.106l1108B. doi:10.1063/1.4916236. Archived from the original on 21 June 2024. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help); Unknown parameter |article-number= ignored (help)
  33. ↑ 33.0 33.1 Dong, Xingchen; Li, Hongwei; Wang, Kun; Menze, Bjoern; Jakobi, Martin; Yetisen, Ali K.; Koch, Alexander W. (18 June 2023). "Multispectral Microscopic Multiplexed (3M) Imaging of Atomically-Thin Crystals Using Deep Learning". Advanced Optical Materials. 12 (2). doi:10.1002/adom.202300860. Unknown parameter |article-number= ignored (help)
  34. ↑ Dong, Jie; Yetisen, Ali K.; Zhao, Chen; Dong, Xingchen; Brändle, Franziska; Wang, Qi; Jakobi, Martin; Saur, Dieter; Koch, Alexander W. (2021). "Single-Shot High-Throughput Phase Imaging with Multibeam Array Interferometric Microscopy". ACS Photonics. 8 (12): 3536–3547. Bibcode:2021ACSP....8.3536D. doi:10.1021/acsphotonics.1c01124.
  35. ↑ Dong, Jie; Yetisen, Ali K.; Dong, Xingchen; Pöller, Franziska; Jakobi, Martin; Liu, Zhanwei; Salazar Bloise, Félix; Koch, Alexander W. (24 September 2020). "Low Pass Filtering Compensation in Common Path". Applied Physics Letters. 117 (12). doi:10.1063/5.0019209. Archived from the original on 22 March 2025. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  36. ↑ Dong, Xingchen; Yetisen, Ali K.; Tian, Heng; Güler, İnci; Stier, Andreas V.; Li, Zhendong; Köhler, Michael H.; Dong, Jie; Jakobi, Martin; Finley, Jonathan J.; Koch, Alexander W. (2020). "Line-Scan Hyperspectral Imaging Microscopy with Linear Unmixing for Automated Two-Dimensional Crystals Identification". ACS Photonics. 7 (5): 1216–1225. Bibcode:2020ACSP....7.1216D. doi:10.1021/acsphotonics.0c00050.
  37. ↑ Dong, Xingchen; Yetisen, Ali K.; Köhler, Michael H.; Dong, Jie; Wang, Shengjia; Jakobi, Martin; Zhang, Xiaoxing; Koch, Alexander W. (23 May 2019). "Microscale Spectroscopic Mapping of 2D Optical Materials". Advanced Optical Materials. 7 (18). doi:10.1002/adom.201900324. Unknown parameter |article-number= ignored (help)
  38. ↑ Bresnahan, Samantha (26 July 2023). "Researchers are developing injectable 'smart tattoos' that could someday monitor your health". CNN. Archived from the original on 9 March 2025. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  39. ↑ Dhond, K.; Hu, Y.; Yetisen, A. K. (2023). "Rethinking point-of-care testing". Die Dermatologie. 74 (10): 819–821. doi:10.1007/s00105-023-05195-6. PMC 10516771 Check |pmc= value (help). PMID 37450053 Check |pmid= value (help).
  40. ↑ "These Color Changing Tattoos Could Help Millions Monitor Their Health". www.weforum.org. Retrieved 1 September 2025.
  41. ↑ "Tattoos Could Soon Be Used to Monitor Health". www.bbc.co.uk. Retrieved 1 September 2025.
  42. ↑ Yetisen, A. K.; Davis, J.; Coskun, A. F.; Church, G. M.; Yun, S. H. (2015). "Bioart". Biotechnology. 33 (12): 724–734. doi:10.1016/j.tibtech.2015.09.011. PMID 26617334. Retrieved 1 September 2025.
  43. ↑ "Sensors and Diagnostics". www.rsc.org. Archived from the original on 11 July 2025. Retrieved 1 September 2025. Unknown parameter |url-status= ignored (help)
  44. ↑ "Editorial Board". Advanced Sensor and Energy Materials. Retrieved 1 September 2025.



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