Amy S. Gladfelter
| Amy S. Gladfelter | |
|---|---|
| Born | 27 April 1974 Philadelphia, Pennsylvania, United States |
| 🏡 Residence | US |
| 🏳️ Citizenship | American |
| 🎓 Alma mater |
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| 💼 Occupation | |
| 🏅 Awards |
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| 🌐 Website | gladfelterlab |
Amy S. Gladfelter (born 27 April 1974) is a quantitative cell biologist and Associate Professor of Biology at the University of North Carolina at Chapel Hill, where she mainly investigate cell cycle-control and the septin cytoskeleton.[4] During her work, she has discovered that multinucleated cells can undergo the cell cycle asynchronously. Additionally, she has been able to determine how septin filaments assemble and the impacts their malfunction have. She has trained and mentored many undergraduate and graduate students, as well as postdoctoral fellows. Due to her advancements in Cell Biology, the American Society for Cell Biology named her the winner of the 2015 WICB Mid-Career Award for Excellence in Research.
Early Life and Education[edit]
Gladfelter was born in Philadelphia, PA on April 27th, 1974. She grew up in Windermere, Florida and graduated from West Orange High School in 1992. It was during high school that Gladfelter became interested in Biology, primarily due to exploring the natural world that the Florida countryside had to offer.[5] Gladfelter attended and graduated from Princeton University with a B.A. in Molecular Biology in 1996. During her undergraduate summers, she spent extensive time doing research with Simon Lewis at the University of Texas Medical Branch, Toby Bradshaw at the University of Washington, and later Bonnie Bassler at Princeton. She then attended Duke University where she worked in Danny Lew’s lab, exploring how cells polarize and CDC42 signaling. In 2001 she graduated from Duke University with a Ph.D. in Genetics. Following her time at Duke, she conducted post-doctoral research on the control of nuclear division in multinucleate fungal cells with Peter Philippsen at the University of Basel Biozentrum in Basel, Switzerland. [6]
Cell Biology Research[edit]
Following her post doctorate work in Switzerland, Gladfelter returned to the United States and began work at Dartmouth College in 2006. She had her own lab which dealt with the arrangement of cells in time and space, and the organization of the septin cytoskeleton in cells. Her lab combined live cell microscopy and computational approaches with biochemistry and genetics analyses to attain results. [7] One of the most significant discoveries Gladfelter made was asynchronous nuclear division in multinucleated cells. This discovery came in Ashbya gossypii cells, where nuclei that shared the same cytoplasm were found to go through the cell cycle completely independent of each other.[8] During her time at Dartmouth, Gladfelter also taught a full load of courses while she served as an associate professor of Biology. Additionally, she mentored undergraduate and graduate students, as well as post doctorates in her lab. Her leadership earned her the Graduate Student Mentoring Award from Dartmouth in 2014.[2]
A few years after starting at Dartmouth, Gladfelter began to work with Rudolf Oldenbourg and Tomomi Tani during summers at the Marine Biological Laboratory in Woods Hole, MA.[9] One of her main focuses at the MBL is septin, and in particular the “orientation and dynamics of individual septin molecules with higher-order structures.”[10]
In 2016, Gladfelter left Dartmouth and began working at the University of North Carolina at Chapel Hill. She currently serves as an Associate Professor of Biology and has her own lab. [4] As before at Dartmouth, her lab at UNC employs both students and post-doctoral trainees to further investigate how cells are organized in time and space.[11] The two main concepts she covers are how the cytoplasm is spatially organized and how cells know their own geometry. “Large multinucleate cells such as fungi, mammalian cancer lines, muscle, and placenta” are used to study the construction of the cytoplasm. It is these cells that are of interest because of the challenges they face in cell division and growth due to their size. [12] Additionally, multinucleate cells are common in tumors, making her lab work extremely relevant as we try to better understand how multinucleate tumor cells form. Recent discoveries include the aggregation of proteins that form liquid-like droplets within the cytosol, representing biological phase separation (liquid-liquid phase separation).
The second area Gladfelter’s lab explores is how the plasma membrane organizes and remodels itself. Because septins are used by the plasma membrane in areas that change shape, they are the proteins Gladfelter and her team examine. Septin is involved in many processes that occur in eukaryotic cells. Along with other things, septin plays a significant role during cytokinesis, forms diffusion barriers to hold cellular components in place, and regulates cellular processes such as the release of neurotransmitters and microtubule dynamics.[13] Because septin has such a fundamental role in various cellular processes, understanding more about it can lead to a better understanding of the cell itself. Gladfelter has “discovered how septins polymerize with [her] establishment of the first reconstitution system that can analyze septin dynamics on supported lipid bilayers.”[12] Septin malfunctions have been linked to many different types of tumors, making Gladfelter’s investigation of them useful in understanding septin's impact on malignant cells. [14]
Awards and honors[edit]
- NSF Post-Doctoral Fellow (2002-2005)
- Roche Research Foundation Fellow (2002-2003)
- Basil O’Connor Scholar, March of Dimes (2008-2010)
- Lemann, Colwin and Spiegel research awards, Marine Biological Lab, Woods Hole, MA (2010, 2011, 2012)[15][16][17]
- Karen E. Wetterhahn Memorial Award for Distinguished Creative and Scholarly Achievement (2012)[3]
- Douglas C. Floren Fellow (2012-2013)
- Nikon Fellow, MBL, Woods Hole, MA (2013)[9]
- Dartmouth Graduate Advising Mentoring Award (2014)[2]
- American Society for Cell Biology, 2015 WICB Mid-Career Award for Excellence in Research Achievement (2015)
- HHMI Faculty Scholar (2016)[1]
Personal life[edit]
Gladfelter is married to Mark Borsuk, an Associate Professor of Civil and Environmental Engineering at Duke University.[18][19] They live in North Carolina with their two children. She returns to Woods Hole, MA every summer with her family to enjoy Cape Cod and continue her work at the MBL. [10][20]
References[edit]
- ↑ 1.0 1.1 "The 2016 Faculty Scholars". Howard Hughes Medical Institute. Retrieved November 30, 2017.
- ↑ 2.0 2.1 2.2 "Faculty Mentoring Award". Dartmouth. Retrieved November 30, 2017.
- ↑ 3.0 3.1 Chapman, Keith (July 20, 2012). "Ten Professors Honored with Faculty Awards". Dartmouth. Dartmouth News. Retrieved November 30, 2017.
- ↑ 4.0 4.1 "The Gladfelter Lab". The University of North Carolina at Chapel Hill. Retrieved November 30, 2017.
- ↑ Salazar, Desiree (September 1, 2015). "Serpe, Gladfelter, and Amon to Receive 2015 WICB Awards". American Society of Cell Biology. Retrieved November 30, 2017.
- ↑ "Curriculum Vitae: Amy S. Gladfelter" (PDF). Dartmouth Directory. March 2013. Retrieved November 30, 2017.
- ↑ "Gladfelter Lab". Dartmouth. December 13, 2011. Retrieved November 30, 2017.
- ↑ Gladfelter, Amy; Hungerbuehler, Katrin; Philippsen, Peter (January 30, 2006). "Asynchronous nuclear division cycles in multinucleated cells". The Journal of Cell Biology. 172: 347–362. doi:10.1083/jcb.200507003.
- ↑ 9.0 9.1 "Amy Gladfelter". Marine Biology Laboratory. Retrieved November 30, 2017.
- ↑ 10.0 10.1 Sedwick, Caitlin (February 17, 2014). "Amy Gladfelter: Fungi with a streak of individuality". The Journal of Cell Biology. 204: 464–465. doi:10.1083/jcb.2044pi.
- ↑ Marine Biological Laboratory. "How molecules in cells 'find' one another and organize into structures." ScienceDaily. ScienceDaily, 12 April 2018. <www.sciencedaily.com/releases/2018/04/180412141037.htm>
- ↑ 12.0 12.1 "Amy Gladfelter". UNC Lineberger. Retrieved November 30, 2017.
- ↑ Valadares, Napoleão; Pereira, Humberto; Araujo, Ana Paula; Garratt, Richard (October 2017). "Septin Structure and filament assembly". Biophysical Reviews. 9: 481–500. doi:10.1007/s12551-017-0320-4.
- ↑ Angelis, Dimitrios; Spiliotis, Elias (November 9, 2016). "Septin Mutations in Human Cancers". Frontiers in Cell and Developmental Biology. 4: 122. doi:10.3389/fcell.2016.00122.
- ↑ "2010 MBL Research Awards". Marine Biological Laboratory. Retrieved November 30, 2017.
- ↑ "2011 MBL Research Awards". Marine Biological Laboratory. Retrieved November 30, 2017.
- ↑ "2012 MBL Research Awards". Marine Biological Laboratory. Retrieved November 30, 2017.
- ↑ Solomon, Brian (April 8, 2016). "We Lose Another Star (Or Two)". Dartmouth’s Daily Blog. Retrieved November 30, 2017.
- ↑ "Mark Borsuk". Duke University. Retrieved November 30, 2017.
- ↑ Heppert, Jennifer (January 5, 2017). "How Cell Biologists Work: Amy Gladfelter on the "random-skip," using your intuition, and crossing things off". American Society of Cell Biology. Retrieved November 30, 2017.
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