AsdA small RNA
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| AsdA sRNA (antisense RNA of dnaA mRNA) | |
|---|---|
 Predicted secondary structure and sequence conservation of AsdA small RNA | |
| Identifiers | |
| Rfam | RF02674 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0043488 |
| SO | SO:0000077, SO:0000370 |
| PDB structures | PDBe |
AsdA (antisense RNA of dnaA) is a cis-encoded antisense RNA of dnaA described in Salmonella enterica serovar Typhi.[1] It was discovered by deep sequencing and its transcription was confirmed by Northern blot and RACE analysis. AsdA, estimated to be about 540 nucleotides long,[2] and represents the complementary strand to that encoding DnaA, a protein that plays a central role in the initiation of DNA replication and hence cellular division.[1] In rich media, it is highly expressed only after reaching the stationary growth phase, but it under limiting iron or osmotic stress it is already expressed during exponential growth.[1] Overexpression of AsdA stabilizes dnaA mRNA, increasing its levels and thereby enhance its rate of translation.[1] This suggests that AsdA is a regulator of DNA replication.[1]
The AsdA sRNA should not be confused with protein-coding asdA genes which encode aminotransferases and other enzymes.
References[edit]
- ↑ 1.0 1.1 1.2 1.3 1.4 Oliva, Giulia; Sahr, Tobias; Buchrieser, Carmen (2015-05-25). "Small RNAs, 5′ UTR elements and RNA-binding proteins in intracellular bacteria: impact on metabolism and virulence". FEBS Microbiology Reviews. 39 (3): 331–349. doi:10.1093/femsre/fuv022. PMID 26009640.
- ↑ Dadzie, Isaac; Xu, Shungao; Ni, Bin; Zhang, Xiaolei; Zhang, Haifang; Sheng, Xiumei; Xu, Huaxi; Huang, Xinxiang (2013-01-01). "Identification and characterization of a cis-encoded antisense RNA associated with the replication process of Salmonella enterica serovar Typhi". PloS One. 8 (4): e61308. doi:10.1371/journal.pone.0061308. ISSN 1932-6203. PMC 3634043. PMID 23637809.
External links[edit]
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