Artificial microRNA

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Artificial microRNA (amiRNA) ia a type of miRNA which is derived by replacing native miRNA duplexes from a natural miRNA precursor.

Key features of an amiRNA[edit]

  • An amiRNA should have secondary structural similarity that of its precursor.
  • It can be processed by host machinery as normal miRNA.
  • After processing it will produce amiRNA:amiRNA* duplex instead of natural miRNA:miRNA* duplex.
  • It should have the ability to confer PTGS to a specific target.

Types of amiRNA[edit]

  • monocistronic amiRNA- amiRNA produces only one amiRNA:amiRNA* duplex
  • Dicistronic amiRNA- produces two amiRNA:amiRNA duplex of same type or different type
  • Polycistronic amiRNA- can produce more than two types of amiRNA:amiRNA* duplex

Use of amiRNA[edit]

  • amiRNA is a new strategy having huge potential. As a PTGS, it is tested to confer viral resistance in plants. Nonetheless, more research must be done to improve a better strategy which can confer resistance to fungal and bacterial diseases.

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