Assembloids
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Assembloids are self-organizing three-dimensional multi-cellular structures obtained from the combination of different organoids or the combination of organoids and other cell lineages. They can be derived from stem cells or tissue parts, and can be used to study cell migration, neural circuit formation and other cell-cell interactions and tissue processes.[1][2]. For instance, forebrain assembloids can model interneuron migration into the cerebral cortex, and cortico-motor assembloids can reconstitute aspects of the cortico-spinal-muscle circuit in vitro[3]. The development and applicatiosn of assembloids was described in a 2022 TED talk. [4]
References[edit]
- ↑ Pasca, SP (2019). "Assembling human brain organoids". Science. 363 (6423): 126–127. Bibcode:2019Sci...363..126P. doi:10.1126/science.aau5729. PMID 30630918. Unknown parameter
|s2cid=ignored (help) - ↑ Schmidt, C (2021). "The rise of the assembloid". Nature. 597 (7878): S22–S23. Bibcode:2021Natur.597S..22S. doi:10.1038/d41586-021-02628-x. Unknown parameter
|s2cid=ignored (help) - ↑ Fan, Shelly (12 January 2021). "Meet Assembloids, Mini Human Brains With Muscles Attached". Singularity Hub.
- ↑ "Sergiu P. Pasca: How we're reverse engineering the human brain in the lab". 24 August 2022.
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