DHDK
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| File:1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one.png | |
| File:1,7-Bis(4-hydroxyphenyl)hepta-4-6-dien-3-one Ball-and-Stick Model.png | |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}} |
| Chemical and physical data | |
| Formula | C19H18O3 |
| Molar mass | 294.3 g·mol−1 |
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DHDK is a natural chemical derivative from Viscum coloratum leaves[1], a subspecies of mistletoe, where it acts as a plant metabolite. This chemical has been theorized to have great cancer fighting properties, especially among breast cancer[2] and lung cancer[3].[1]
Reasoning for DHDK being targeted for cancer treatment is its increased bioavailability, anti-tumor activity, and better stability[1] compared to Curcuma longa[4].
References
- ↑ 1.0 1.1 1.2 Hong, Jing; Meng, Lin; Yu, Peipei; Zhou, Ceng; Zhang, Zhaoyan; Yu, Zhiguo; Qin, Feng; Zhao, Yunli (2020). "Novel drug isolated from mistletoe (1E,4E)-1,7-bis(4-hydroxyphenyl)hepta-1,4-dien-3-one for potential treatment of various cancers: synthesis, pharmacokinetics and pharmacodynamics". RSC Advances. 10 (46): 27794–27804. Bibcode:2020RSCAd..1027794H. doi:10.1039/d0ra03674a. ISSN 2046-2069. PMC 9055608 Check
|pmc=value (help). PMID 35516963 Check|pmid=value (help). - ↑ Grossarth-Maticek, R.; Ziegler, Renatus (2006-11-30). "Randomised and non-randomised prospective controlled cohort studies in matched-pair design for the long-term therapy of breast cancer patients with a mistletoe preparation (Iscador): a re-analysis". European Journal of Medical Research. 11 (11): 485–495. ISSN 0949-2321. PMID 17182361.
- ↑ Bar-Sela, Gil; Wollner, Mira; Hammer, Liat; Agbarya, Abed; Dudnik, Elizabeth; Haim, Nissim (March 2013). "Mistletoe as complementary treatment in patients with advanced non-small-cell lung cancer treated with carboplatin-based combinations: a randomised phase II study". European Journal of Cancer (Oxford, England: 1990). 49 (5): 1058–1064. doi:10.1016/j.ejca.2012.11.007. ISSN 1879-0852. PMID 23218588.
- ↑ Anand, Preetha; Kunnumakkara, Ajaikumar B.; Newman, Robert A.; Aggarwal, Bharat B. (2007). "Bioavailability of curcumin: problems and promises". Molecular Pharmaceutics. 4 (6): 807–818. doi:10.1021/mp700113r. ISSN 1543-8384. PMID 17999464. Unknown parameter
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hepta-4,6-dien-3-one.png){kind=link}
hepta-4-6-dien-3-one_Ball-and-Stick_Model.png){kind=link}