David Beeson
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David Beeson FMedSci is an Emeritus Professor in the Nuffield Department of Clinical Neurosciences at the University Of Oxford[1] and a fellow of St Cross College.[2] Working closely with clinical colleagues, he and his team discovered many of the genetic causes and pathogenic mechanisms of Congenital Myasthenic Syndromes, and helped develop the use of personalised treatments to target different mechanisms of disease.[3] This led to the NHS commissioning a National Specialist Diagnostic and Advisory Service for congenital myasthenic syndromes led from Oxford.[3][4]
Career and research[edit]
Beeson studied for his undergraduate degree at Magdalene College Cambridge, before undertaking a PhD with Professor Eric Barnard at Imperial College, London focusing on the first cloning of muscle acetylcholine receptors. He joined the groups of John Newsom-Davis and Angela Vincent at the Royal Free Hospital, London before the completion of his PhD in 1987. He moved with them as part of the Neurosciences Group to the Weatherall Institute of Molecular Medicine, University of Oxford in 1988. In 1995 he was made an Honorary University Lecturer by the University of Oxford. In 1998 Beeson received an MRC Senior Non-Clinical Fellowship, which was renewed in 2003. In 2004 he received a personal chair from the University of Oxford.[1]
Beeson was the first to sequence the epsilon gene of human muscle acetylcholine receptors, which he published in 1993.[5] This was critical to the discovery of the genetic origins of Congenital Myasthenic Syndromes, as these are most commonly found in this gene. His group later identified numerous other genes in which mutations lead to congenital myasthenic syndromes, including several that are involved in protein glycosylation, despite their ubiquitous expression.[6][7][8]
His group also demonstrated how beta adrenergic receptor agonists like salbutamol work for patients of congenital myasthenic syndromes, and helped establish their use in combination with choline esterase inhibitors as a frontline treatment for this condition[9]
References[edit]
- ↑ 1.0 1.1 "David Beeson". www.ndcn.ox.ac.uk.
- ↑ "Professor David Beeson". www.stx.ox.ac.uk. Retrieved 2021-10-16.
- ↑ 3.0 3.1 "Professor David Beeson | The Academy of Medical Sciences". acmedsci.ac.uk.
- ↑ "Oxford Congenital Myasthenia Service - Oxford University Hospitals". www.ouh.nhs.uk.
- ↑ Beeson, David; Brydson, Martin; Betty, Maria; Jeremiah, Steve; Povey, Sue; Vincent, Angela; Newsom-Davis, John (October 13, 1993). "Primary structure of the human muscle acetylcholine receptor". European Journal of Biochemistry. 215 (2): 229–238. doi:10.1111/j.1432-1033.1993.tb18027.x. PMID 7688301 – via Wiley Online Library.
- ↑ Belaya, Katsiaryna; Finlayson, Sarah; Slater, Clarke R.; Cossins, Judith; Liu, Wei Wei; Maxwell, Susan; McGowan, Simon J.; Maslau, Siarhei; Twigg, Stephen R.F.; Walls, Timothy J.; Pascual Pascual, Samuel I.; Palace, Jacqueline; Beeson, David (July 13, 2012). "Mutations in DPAGT1 Cause a Limb-Girdle Congenital Myasthenic Syndrome with Tubular Aggregates". American Journal of Human Genetics. 91 (1): 193–201. doi:10.1016/j.ajhg.2012.05.022. PMC 3397259. PMID 22742743.
- ↑ Cossins, Judith; Belaya, Katsiaryna; Hicks, Debbie; Salih, Mustafa A.; Finlayson, Sarah; Carboni, Nicola; Liu, Wei Wei; Maxwell, Susan; Zoltowska, Katarzyna; Farsani, Golara Torabi; Laval, Steven; Seidhamed, Mohammed Zain; Donnelly, Peter; Bentley, David; McGowan, Simon J.; Müller, Juliane; Palace, Jacqueline; Lochmüller, Hanns; Beeson, David (March 13, 2013). "Congenital myasthenic syndromes due to mutations in ALG2 and ALG14". Brain. 136 (3): 944–956. doi:10.1093/brain/awt010. PMC 3580273. PMID 23404334.
- ↑ Belaya, Katsiaryna; Rodríguez Cruz, Pedro M.; Liu, Wei Wei; Maxwell, Susan; McGowan, Simon; Farrugia, Maria E.; Petty, Richard; Walls, Timothy J.; Sedghi, Maryam; Basiri, Keivan; Yue, Wyatt W.; Sarkozy, Anna; Bertoli, Marta; Pitt, Matthew; Kennett, Robin; Schaefer, Andrew; Bushby, Kate; Parton, Matt; Lochmüller, Hanns; Palace, Jacqueline; Muntoni, Francesco; Beeson, David (September 13, 2015). "Mutations in GMPPB cause congenital myasthenic syndrome and bridge myasthenic disorders with dystroglycanopathies". Brain. 138 (9): 2493–2504. doi:10.1093/brain/awv185. PMC 4547052. PMID 26133662.
- ↑ Vanhaesebrouck, An E; Webster, Richard; Maxwell, Susan; Rodriguez Cruz, Pedro M; Cossins, Judith; Wickens, James; Liu, Wei-wei; Cetin, Hakan; Cheung, Jonathan; Ramjattan, Hayley; Palace, Jacqueline; Beeson, David (December 1, 2019). "β2-Adrenergic receptor agonists ameliorate the adverse effect of long-term pyridostigmine on neuromuscular junction structure". Brain. 142 (12): 3713–3727. doi:10.1093/brain/awz322. PMC 6892641 Check
|pmc=value (help). PMID 31633155 – via Silverchair.
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