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Deborah Marie Muoio

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Deborah Marie Muoio
Dr.
BornDeborah Marie Molnar
🏳️ NationalityAmerican
💼 Occupation
👩 Spouse(s)Joseph Muoio
🏅 AwardsGeorge Barth Geller Distinguished Professor of Cardiovascular Disease-Duke University (2021).

Duke Claude D. Pepper Older Americans Independence Center Scholar Award- Duke University (2009)

Journal of Lipid Research Lectureship & Award, Keystone Symposium on Diabetes (Journal of Lipid Research) (2011)
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Deborah Marie Muoio is an American professor of medicine, cancer biology, cardiovascular disease, and pharmacology at Duke University for the past 21 years, She has been recognized for her research in diabetes, metabolic regulation, mitochondrial energy, muscle physiology and exercise. She has published over one hundred articles in scientific journals, in addition to her book, “Metabolic Mechanisms of Muscle Insulin Resistance.” She attended the University of Florida and University of North Carolina, Chapel Hill while earning her bachelor’s degree and PhD. Muoio is a member of the Duke Cancer Institute and has earned several distinguished awards for her research and contributions to science.

Early life and Education[edit]

Deborah Marie Muoio, born Deborah Marie Molnar, grew up in the Buffalo area of New York. She earned her Bachelor’s of Science Degree at the University of Florida. After which she originally planned to pursue medical school but instead returned to western New York to University of Buffalo to complete her masters degree in nutrition in 1988. During her time in the masters program she began extended research and decided that she wanted to continue her career as a researcher[1]. In September of 1989 she married her husband Joseph Muoio in Buffalo New York. She then went on to earn her PhD in nutritional biochemistry at the University of North Carolina, Chapel Hill in 1999. Deborah Marie Muoio completed postdoctoral fellowships at East Carolina and Duke Universities working in muscle physiology and metabolic disease and continues to focus on research and mentoring students.[2]

Career and Research[edit]

Dr. Deborah Marie Muoio is a Professor of Medicine Division of Endocrinology, and Director of Basic Research at the Duke Molecular Physiology Institute[3]. Munio is known for her research in diabetes, physiological aspects of exercise and muscles, metabolism, mitochondria, and obesity/ [4]  Her laboratory focuses on the mechanisms of metabolic control and molecular events that link nutrition and exercise to health outcomes. Her lab possesses a translational approach combining basic science and human studies with mass spectrometry [3]. As a professor, Munio conducts many lectures about her research, such as Michael Brownlee Visiting Professor Lectureship in Diabetes Research in the Joslin Diabetes Center, Boston, MA (2020).

The overarching goal of her work is “to guide the development of new lifestyle, nutraceutical and/or pharmacological strategies to maintain mitochondrial and metabolic health”.

Dr. Muoio laboratory has developed a platform for deep and comprehensive assessment of mitochondrial bioenergetics and energy transduction. [5] As a Professor in Duke, currently teaches Pharmacology 393, 493, and 494 which are all independent research studies at Duke.

Awards and Recognition[edit]

  • July 2021– George Barth Geller Distinguished Professor of Cardiovascular Disease (Duke University)[6].
  • 2017- Anna Lee Memorial Lecture (BIDMC, Division of Endocrinology)[7].
  • 2017- Frank Weaver Booth III Lectureship in Physical Activity, Exercise, and Health (University of Missouri)[8].
  • 2014- Ed Tapscott Memorial Lecture, Taft Diabetes and ECDOI (East Carolina University)[9].
  • 2011- Journal of Lipid Research Lectureship & Award, Keystone Symposium on Diabetes (Journal of Lipid Research)[10].
  • 2009- Duke Claude D. Pepper Older Americans Independence Center Scholar Award (Duke University)[11].
  • 2008- David L. Williams Lectureship & Award (Kern Aspen Lipid Conference)[12].

Grants Awarded[edit]

Dr. Muoio has received multiple grants and awards in order to support her research, and continue to develop her ongoing investigations. She has served multiple roles while involved in such grants, and throughout her time as a researcher she has received over 20 different grants for various projects.

Some of her notable grants are:

  • Probing the Role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart, awarded by the University of Pennsylvania in 2017 and continued through 2019. In this grant she served as the principal investigator[13]
  • Ketone Dysregulation and Muscle Insulin Resistance, awarded by the National Institutes of Health in 2004 and which continued through 2007. In this grant she served as the principal investigator[14].
  • Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience, awarded by the National Institutes of Health in 2022 and which will continue on until 2027. In this grant she serves as the principal investigator[15].
  • STIM1 and metabolic flexibility which was awarded by the National Institutes of Health in 2017 and it continued through 2022. In this grant she served as the co-primary investigator[16].
  • Role of carnitine acetyltransferase in mitochondrial function and insulin action, awarded by the National Institutes of Health in 2007 and which continued through 2009. In this grant she served as the principal investigator[17].

Publications[edit]

Dr. Muoio has published over 120 articles in numerous different scientific journals since she began publishing research in 1994. Since 1994 she has continued to publish research as recently as January 2023. Her worked has been cited in over more than 15,000 different publications.

Some key publications she has been involved in and which has been cited most frequently in further research include:

  • Metabolic Mechanisms of Muscle Insulin Resistance - a chapter in a novel published in 2007 in which she co-authored[18].
  • Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance- an academic article in which she co-authored in 2008. This article has been cited in further research the most of any of her other papers.
  • Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis- an academic article in which she co-authored in July of 2022[19].
  • Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism- an academic article in which she co-authored in December 2022[19].
  • Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population- an academic article published by the clinical journal of the American Society of Nephrology, in which she co-authored, in January 2023[19].

References[edit]

  1. "Exercise and Nutrition Sciences". publichealth.buffalo.edu. Retrieved 2023-03-14.
  2. "Deborah M Muoio Phd | Diabetes Research Centers". diabetescenters.org. Retrieved 2023-03-14.
  3. 3.0 3.1 "Deborah M Muoio Phd | Diabetes Research Centers". diabetescenters.org. Retrieved 2023-03-14.
  4. "Deborah Marie Muoio | Duke Department of Medicine". medicine.duke.edu. Retrieved 2023-03-14.
  5. "Muoio, Deborah Marie". Duke Cancer Institute. Retrieved 2023-03-14.
  6. "Deborah Marie Muoio | Duke University School of Medicine". medschool.duke.edu. Retrieved 2023-03-14.
  7. "Endocrinology Grand Rounds". www.bidmc.org. Retrieved 2023-03-14.
  8. "Frank Weaver Booth III Lectureship in Physical Activity, Exercise and Health . University of Missouri. | Scholars@Duke". scholars.duke.edu. Retrieved 2023-03-14.
  9. "Ed Tapscott Memorial Lecture, Taft Diabetes and ECDOI. East Carolina University, Greenville, NC. | Scholars@Duke". scholars.duke.edu. Retrieved 2023-03-14.
  10. "Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics". tks.keystonesymposia.org. Retrieved 2023-03-14.
  11. https://www.peppercenter.org/docs/annualdir/2009OAIC_Directory.pdf
  12. https://www.kernconference.org/archive/2008_program.pdf
  13. "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2023-03-13.
  14. "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2023-03-13.
  15. "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2023-03-13.
  16. "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2023-03-14.
  17. "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2023-03-14.
  18. editor., Mohan, Viswanathan, editor. Unnikrishnan, Ranjit. Type 2 diabetes mellitus. ISBN 978-93-5250-103-8. OCLC 1055594071.CS1 maint: Extra text: authors list (link) Search this book on
  19. 19.0 19.1 19.2 "Deborah M Muoio's research while affiliated with Molecular Biology Institute of Barcelona and other places".


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