Drupad K Trivedi

Dr Drupad K Trivedi PhD, AFHEA
Pronunciation	d-r-uu-p-uh-d
Born
🎓 Alma mater	Middlesex University (BSc Hons and PhD)
💼 Occupation	Researcher
Known for	Biotechnology, Metabolomics, Biomarkers
🏅 Awards	Community of Analytical Sciences Lectureship (2020), Royal Society of Chemistry Horizon Prize (2021).

Drupad K Trivedi is a British Indian biomedical scientist born in India, with an expertise in metabolomics and chemometrics analysis for disease diagnosis. He is a researcher and lecturer in the Department of Chemistry at The University of Manchester. His research is broadly based on detection of small molecules for biomarker discovery. His notable contributions are in the field of Parkinson's disease, tuberculosis and COVID-19 diagnosis using small molecules associated with the smell of diseases.

Education

Trivedi completed his Bachelor of Science degree in Metabolomics in 2008 at Middlesex University. He immediately embarked upon a PhD at the same university and successfully completed it in 2012. His doctoral work was published in 2012. after patenting the discovery. His PhD on discovery of Down syndrome biomarkers in maternal urine using hybrid mass spectrometry was supervised by Prof Ray K Iles.

Research and career

Upon completing his PhD, Trivedi completed his short postdoctoral research at London School of Hygiene and Tropical Medicine where he spent time on developing mass spectrometry assays to detect counterfeit anti-malaria drugs with Dr Harparkash Kaur. He then joined Prof Royston Goodacre in Manchester at the University of Manchester as a Post Doctoral Research Associate in cancer Metabolomics and informatics from 2013 to 2017. He started working with Prof Perdita Barran for detection of smell associated biomarkers of Parkinson's disease. Trivedi was the lead analytical scientist on the project who led volatilome and metabolome analysis. While working with Prof Barran, Trivedi continued exploring association of smell with diseases. After Joy Milne, the lady who can smell Parkinson's, visited Tanzania, Trivedi embarked on a journey to decode the smell of tuberculosis. In 2019, he authored the first paper that established a link between volatile organic compounds present in sebum and Parkinson's disease. In 2020, he was awarded a Lectureship at the University of Manchester, funded by Community of Analytical and Measurement Sciences where he began his independent research for tuberculosis wearables that can detect odourous compounds.

Notable work

In 2019, Trivedi and Barran published the first paper that linked odourous volatile compounds to a disease diagnostic pathway. Trivedi was the first author and analytical lead on the paper. This paper has led to a surge in investigation of sebum for disease diagnosis. This first paper in the field described sebum as a potential biofluid that can indicate state of a disease in humans. The landmark paper has been covered by 182 news outlets around the world including Discover Magazine, NPR and Scientific American. Following this work, recently a team of mass spectrometrists including Barran and Trivedi have shown the potential of sebum as a diagnostic biofluid for detection of COVID-19 infection using a simple skin swab.

Awards and nominations

In 2019, Trivedi was awarded for his outstanding achievement in analytical chemistry by the University of Manchester. In the same year, Royal Society of Chemistry awarded him for the best poster prize in RSC Analytical Sciences for communicating the science around smell of Parkinson's in RSC Poster competition on Twitter. In 2021, Trivedi was awarded Royal Society of Chemistry Horizon Prize along with the team that worked towards discovery of volatile organic compounds as biomarkers for Parkinson's disease.

Major publications

• Black R, Trivedi DK* et al (2021) Characterization of native protein structure with ion mobility mass spectrometry, multiplexed fragmentation strategies and multivariant analysis, International Journal of Mass Spectrometry, 464, 116588
• Sinclair E, Trivedi DK et al. (2021) Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease, Nature Communications, 12 (1), 1-9.
• Spick M, Trivedi DK* et al (2021), Changes to the sebum lipidome upon COVID-19 infection observed via rapid sampling from the skin, EClinicalMedicine, 33, 100786
• E Sinclair, Trivedi DK* et al (2021), Validating differential Volatilome profiles in Parkinson’s disease, ACS Central Sciences, 7(2), 300-306
• Trivedi DK, et al. (2019), Discovery of volatile biomarkers of Parkinson’s disease from sebum, ACS Central Sciences, DOI: 10.1021/acscentsci.8b00879
• Trivedi DK, Hollywood K and Goodacre R (2017), Metabolomics for the masses, the future of metabolomics in a personalized world, New Horizons in Translational Medicine, DOI:
• 10.1016/j.nhtm.2017.06.001
• Trivedi DK et al. (2016), Meat, the metabolites: an integrated metabolite profiling and lipidomics approach for the detection of the adulteration of beef with pork
• White MD, Payne KAP, Fisher K, Marshall SA, Parker D, Rattray NJW, Trivedi DK, Goodacre R, Rigby SEJ, Scrutton NS, Hay S and Leys D (2015) UbiX is a Flavin prenyltransferase required for bacterial ubiquinone biosynthesis, Nature, 522, 502-506
• Payne KAP, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJW, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SEJ, Scrutton MS, Hay S and Leys D (2015), New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition, Nature, 522, 497-501

^{*PI or co-I for the work.}

References

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