Eberhard Neumann
| Eberhard Neumann | |
|---|---|
| File:EberhardNeumann.jpgEberhardNeumann.jpg Neumann in 2006 | |
| Born | June 17, 1939 Breslau, Germany (now Wrocław, Poland) |
| 💼 Occupation | |
| Known for | Early work on electroporation for gene transfer into mammalian cells |
| 🏅 Awards | Honorary doctorate, University of Ljubljana (2006) |
Eberhard Neumann (born 17 June 1939) is a German biochemist and biophysicist associated with research on bioelectric phenomena in membranes and the use of electric pulses in biotechnology.[1] He is noted for early work that helped establish electroporation as a method for introducing DNA into mammalian cells.[2][3][4] [5] Later reviews credit Neumann and colleagues with coining the term "electroporation" in 1982.[6][4]
Biography
Neumann was born in Breslau on 17 June 1939.[7] He received a doctorate from the University of Münster in 1967 and completed his habilitation at the University of Konstanz in 1973.[1] From 1975 to 1983 he worked at the Max Planck Institute of Biochemistry in Martinsried.[1] In 1983 he became chair of physical and biophysical chemistry at the University of Bielefeld and retired in 2005.[1]
Research
Neumann's research has addressed the physical chemistry of biological electricity and biotechnological applications of electric pulses, including membrane transport processes relevant to drug and gene delivery.[1]
In early work on electric-field effects on membranes, Neumann and Kurt Rosenheck reported transient permeability changes induced by short electric impulses in vesicular membranes.[8]
In 1980, Neumann and co-workers demonstrated electrically induced cell fusion (electrofusion) in Dictyostelium.[9]
In a 1982 paper, Neumann and co-authors reported that brief high-field electric pulses increased DNA uptake in mouse cells, producing stable transformants, and proposed an "electroporation model" for membrane transport in strong electric fields.[10] [11] A 2006 Nature Methods historical overview described Neumann as an early pioneer who helped advance the use of electroporation for delivering DNA into mammalian cells and noted that his group "dubbed" the process electroporation.[2]
Memberships and honors
Neumann became a member of the European Molecular Biology Organization (EMBO) in 1980.[12] In 1998 he was elected a corresponding member of the Saxon Academy of Sciences and Humanities.[7] In 2004 he served as chair (Vorsitzender / 1. Vorsitzender) of the German Biophysical Society (Deutsche Gesellschaft für Biophysik, DGfB).[13] In 2006, the University of Ljubljana awarded him an honorary doctorate (doctor honoris causa), as reported by the University of Bielefeld.[1]
Selected works
- Neumann, E.; Schaefer-Ridder, M.; Wang, Y.; Hofschneider, P. H. (1982). "Gene transfer into mouse lyoma cells by electroporation in high electric fields". The EMBO Journal. 1(7): 841–845. doi:10.1002/j.1460-2075.1982.tb01257.x. PMID 6329708. PMCID PMC553119.
- Neumann, E.; Kakorin, S.; Toensing, K. (1999). "Fundamentals of electroporative delivery of drugs and genes". Bioelectrochemistry and Bioenergetics. 48(1): 3–16. doi:10.1016/S0302-4598(99)00008-2. PMID 10228565.
- Neumann, E.; Kakorin, S. (2018). "Membrane electroporation: chemical thermodynamics and flux kinetics revisited and refined". European Biophysics Journal. 47(4): 373–387. doi:10.1007/s00249-018-1305-3. PMID 29737373.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Ehrendoktorwürde für Professor Eberhard Neumann (Nr. 198/2006)". Universität Bielefeld (Pressemitteilungen) (in Deutsch). 4 December 2006. Retrieved 28 December 2025.
- ↑ 2.0 2.1 Eisenstein, Michael (January 2006). "A shock to the system". Nature Methods. 3: 66. doi:10.1038/nmeth0106-66.
- ↑ Young, Jennifer L.; Dean, David A. (2015). "Electroporation-mediated gene delivery". Advances in Genetics. 89: 49–88. doi:10.1016/bs.adgen.2014.10.003. PMC 6005385. PMID 25620008.
- ↑ 4.0 4.1 Yarmush, Martin L.; Golberg, Alexander; Serša, Gregor; Kotnik, Tadej; Miklavčič, Damijan (2014). "Electroporation-based technologies for medicine: principles, applications, and challenges". Annual Review of Biomedical Engineering. 16: 295–320. doi:10.1146/annurev-bioeng-071813-104622. PMID 24905876.
- ↑ Stewart, Martin P.; Langer, Robert; Jensen, Klavs F. (2018). "Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts". Chemical Reviews. 118 (16): 7409–7531. doi:10.1021/acs.chemrev.7b00678. PMC 6763210 Check
|pmc=value (help). PMID 30052023. - ↑ Balantič, Katja; Miklavčič, Damijan; Križaj, Igor; Kramar, Peter (2021). "The Good and the Bad of Cell Membrane Electroporation". Acta Chimica Slovenica. 68: 753–764. doi:10.17344/acsi.2021.7198.
- ↑ 7.0 7.1 "Eberhard Neumann, Prof. Dr. rer. nat. habil". Sächsische Akademie der Wissenschaften zu Leipzig (in Deutsch). Retrieved 28 December 2025.
- ↑ Neumann, E; Rosenheck, K (1972). "Permeability changes induced by electric impulses in vesicular membranes". Journal of Membrane Biology. 10 (3): 279–290. doi:10.1007/BF01867861. PMID 4667921.
- ↑ Neumann, E.; Gerisch, G.; Opatz, K. (1980). "Cell fusion induced by high electric impulses applied to Dictyostelium". Naturwissenschaften. 67: 414–415. doi:10.1007/BF00405493.
- ↑ Neumann, E.; Schaefer-Ridder, M.; Wang, Y.; Hofschneider, P. H. (1982). "Gene transfer into mouse lyoma cells by electroporation in high electric fields". The EMBO Journal. 1 (7): 841–845. doi:10.1002/j.1460-2075.1982.tb01257.x. PMC 553119. PMID 6329708.
- ↑ Heller, Richard (11 January 2002). "The development of electroporation". Science. 295 (5553): 277. doi:10.1126/science.295.5553.277a. PMID 11789539.
- ↑ "Eberhard Neumann". EMBO People. Retrieved 28 December 2025.
- ↑ "Rundschreiben 1/2004 (April 2004)" (PDF). Deutsche Gesellschaft für Biophysik e. V. (in Deutsch). Retrieved 28 December 2025.
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