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Dr Edward John Wild

From EverybodyWiki Bios & Wiki

For other people named Edward Wild, see Edward Wild (disambiguation).


Dr Edward John Wild
Edward Wild in March 2015Edward_Wild.jpg Edward_Wild.jpg
Edward Wild in March 2015
Born
🏡 ResidenceLondon, UK
🏳️ NationalityBritish
🎓 Alma materChrist's College, Cambridge (1996-2001)
University College London (2005-2008)
💼 Occupation
Known forHuntington's disease research and outreach
🏅 AwardsHuntington’s Disease Society of America Researcher of the Year, 2014;
Huntington Society of Canada Community Leadership Award, 2013;
Huntington Study Group Insight of the Year, 2015.
🌐 Websiteedwild.com

Edward Wild, also known as Ed Wild, is a British neurologist and neuroscientist in the field of Huntington’s disease and advocate for scientific outreach to the public. He co-founded the Huntington’s research news platform HDBuzz. He is an MRC Clinician Scientist at UCL Institute of Neurology and Consultant neurologist at the National Hospital for Neurology & Neurosurgery in London.[1]

Career[edit]

Wild studied medicine at Christ's College, University of Cambridge. In his early career he studied and published on the neurological phenomenon of déjà vu.[2] He undertook a PhD at UCL Institute of Neurology, Queen Square, London,[3] during which his research established biomarkers for Huntington's disease using magnetic resonance imaging measures of brain atrophy[4][5][6] and biochemical analysis of blood.[7][8] His work has established him as an expert in the field of clinical research and biomarkers for Huntington's disease.[9][10][11] He described a novel pathogenic pathway of immune activation in Huntington’s[12][13] which later became the basis of clinical trials of immune-targeted therapies.[14] In 2015 he published the first successful detection and quantification of mutant huntingtin protein (the known cause of Huntington’s) in human cerebrospinal fluid, using a novel ‘single-molecule counting’ immunoassay. This finding was noted as a 'research highlight' by Nature Reviews Neurology and won Wild the Huntington Study group 'Insight of the Year' award in 2015.[15][16][17] He has also published novel genetic causes of 'phenocopy' syndromes that mimic Huntington's disease.[18][19] As of July 2016, Wild has authored 53 peer-reviewed publications with 3083 citations.[20]

He serves on the Medical Advisory Panel of the UK Huntington's Disease Association,[21] the Editorial Board of the Journal of Huntington's Disease[22] and the Review Board of PLoS Currents: Huntington's Disease,[23] and is a founder member of the advisory panel to the UK All-Party Parliamentary Group on Huntington's Disease.[24][25]

Public Engagement Work[edit]

In 2010, with Jeff Carroll, Wild founded HDBuzz, an online source of accessible news about Huntington's disease research,[26][27][28] which has received awards from patient advocacy groups.[29] Wild has described Huntington's as "the most curable incurable brain disorder" because of the possibility of targeting treatments to its known genetic cause.[30][31]

Wild appeared in the documentary feature film The Inheritance[32][33] and was a judge for the 2015 British Library / Europe PubMed Central 'Access to Understanding' contest for science writers.[34] He has appeared on the BBC Radio Naked Scientists programme.[35] In July 2016 he appeared on BBC Radio 4's Woman's Hour programme talking about Huntington's disease with Jenni Murray.[36]

Awards[edit]

References[edit]

  1. ↑ Hayden, Erika (23 February 2016). "Should you edit your children's genes?". Nature. 530 (7591): 402–405. doi:10.1038/530402a.
  2. ↑ Phillips, Helen (25 March 2009). "Déjà vu: Where fact meets fantasy" (PDF). New Scientist. New Scientist. pp. 3, 5. Archived from the original on 26 March 2009. Retrieved 31 March 2016.
  3. ↑ Wild, Edward. "Identification and evaluation of biomarkers for Huntington's disease (PhD Thesis)". UCL Discovery Institutional Document Repository. University College London.
  4. ↑ Wild, Edward J.; Henley, Susie M. D.; Hobbs, Nicola Z.; Frost, Chris; MacManus, David G.; Barker, Roger A.; Fox, Nick C.; Tabrizi, Sarah J. (2010-05-15). "Rate and acceleration of whole-brain atrophy in premanifest and early Huntington's disease". Movement Disorders: Official Journal of the Movement Disorder Society. 25 (7): 888–895. doi:10.1002/mds.22969. ISSN 1531-8257. PMID 20461806.
  5. ↑ Henley, Susie M. D.; Wild, Edward J.; Hobbs, Nicola Z.; Frost, Chris; MacManus, David G.; Barker, Roger A.; Fox, Nick C.; Tabrizi, Sarah J. (2009-04-30). "Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease". Movement Disorders: Official Journal of the Movement Disorder Society. 24 (6): 932–936. doi:10.1002/mds.22485. ISSN 1531-8257. PMID 19243073.
  6. ↑ Wild, Edward; Hobbs, Nicola; Henley, Susie (2011). "Huntington's Disease and Dementia". Neuroimaging in Dementia. Springer-Verlag. ISBN 3642008178. Search this book on
  7. ↑ Wild, Edward J.; Tabrizi, Sarah J. (2008-01-01). "Biomarkers for Huntington's disease". Expert Opinion on Medical Diagnostics. 2 (1): 47–62. doi:10.1517/17530059.2.1.47. ISSN 1753-0059. PMID 23485116.
  8. ↑ Weiss, Andreas; Träger, Ulrike; Wild, Edward J.; Grueninger, Stephan; Farmer, Ruth; Landles, Christian; Scahill, Rachael I.; Lahiri, Nayana; Haider, Salman (2012-10-01). "Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression". The Journal of Clinical Investigation. 122 (10): 3731–3736. doi:10.1172/JCI64565. ISSN 1558-8238. PMC 3461928. PMID 22996692.
  9. ↑ Wild, Edward; Tabrizi, Sarah (2014). "Premanifest and Early Huntington's Disease". Huntington's Disease (4th ed.). Oxford University Press. ISBN 0199929149. Search this book on
  10. ↑ "Genetic Brain Disease 'Far More Common'". Sky News (via archive.org). Retrieved 2016-03-31.
  11. ↑ Bates, Gillian P.; Dorsey, Ray; Gusella, James F.; Hayden, Michael R.; Kay, Chris; Leavitt, Blair R.; Nance, Martha; Ross, Christopher A.; Scahill, Rachael I. (2015-04-23). "Huntington disease". Nature Reviews Disease Primers: 15005. doi:10.1038/nrdp.2015.5.
  12. ↑ Björkqvist, M; Wild, EJ; Thiele, J; Silvestroni, A; Andre, R; Lahiri, N; Raibon, E; Lee, RV; Benn, CL; Soulet, D; Magnusson, A; Woodman, B; Landles, C; Pouladi, MA; Hayden, MR; Khalili-Shirazi, A; Lowdell, MW; Brundin, P; Bates, GP; Leavitt, BR; Möller, T; Tabrizi, SJ (4 August 2008). "A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease". The Journal of Experimental Medicine. 205 (8): 1869–77. doi:10.1084/jem.20080178. PMC 2525598. PMID 18625748.
  13. ↑ Dalrymple, A; Wild, EJ; Joubert, R; Sathasivam, K; Björkqvist, M; Petersén, A; Jackson, GS; Isaacs, JD; Kristiansen, M; Bates, GP; Leavitt, BR; Keir, G; Ward, M; Tabrizi, SJ (July 2007). "Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates". Journal of Proteome Research. 6 (7): 2833–40. doi:10.1021/pr0700753. PMID 17552550.
  14. ↑ "A Clinical Study in Subjects With Huntington's Disease to Assess the Efficacy and Safety of Three Oral Doses of Laquinimod - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2016-03-31.
  15. ↑ Wild, EJ; Boggio, R; Langbehn, D; Robertson, N; Haider, S; Miller, JR; Zetterberg, H; Leavitt, BR; Kuhn, R; Tabrizi, SJ; Macdonald, D; Weiss, A (May 2015). "Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients". The Journal of Clinical Investigation. 125 (5): 1979–86. doi:10.1172/JCI80743. PMC 4463213. PMID 25844897.
  16. ↑ Chase, Alex (21 April 2015). "Huntington disease: Cerebrospinal fluid and MRI biomarkers for prodromal HD". Nature Reviews Neurology. 11 (5): 245–245. doi:10.1038/nrneurol.2015.63.
  17. ↑ 17.0 17.1 "Announcing HSG's 2015 Award Winners". Huntington Study Group. Retrieved 2016-03-31.
  18. ↑ Hensman Moss, DJ; Poulter, M; Beck, J; Hehir, J; Polke, JM; Campbell, T; Adamson, G; Mudanohwo, E; McColgan, P; Haworth, A; Wild, EJ; Sweeney, MG; Houlden, H; Mead, S; Tabrizi, SJ (28 January 2014). "C9orf72 expansions are the most common genetic cause of Huntington disease phenocopies". Neurology. 82 (4): 292–9. PMID 24363131.
  19. ↑ Wild, EJ; Mudanohwo, EE; Sweeney, MG; Schneider, SA; Beck, J; Bhatia, KP; Rossor, MN; Davis, MB; Tabrizi, SJ (15 April 2008). "Huntington's disease phenocopies are clinically and genetically heterogeneous". Movement disorders : official journal of the Movement Disorder Society. 23 (5): 716–20. PMID 18181206.
  20. ↑ "Dr Edward J Wild - Google Scholar Citations". scholar.google.co.uk. Retrieved 16 August 2016.
  21. ↑ "HDA - Research - Medical advisory panel". hda.org.uk. Retrieved 2016-03-31.
  22. ↑ "IOS Press". www.iospress.nl. Retrieved 2016-03-31.
  23. ↑ "Review Board – PLOS Currents Huntington Disease". currents.plos.org. Retrieved 2016-03-31.
  24. ↑ Harrison, Jacqueline. "The 'hidden no more' mass lobby June 2010 - using oral histories and cultural representations to explore the concealment of Huntington's disease. (Masters Thesis)". University of Huddersfield Repository.
  25. ↑ "Massive Underestimation In The Prevalence Of Huntington's Disease In The UK Population". Science 2.0. Retrieved 2016-03-31.
  26. ↑ Macleod, Rhona; Tibben, Aad. Huntington's Disease (4 ed.). Oxford Universoty Press. p. 171. ISBN 0199370478. Search this book on
  27. ↑ Kenneally, Christine (2015). The Best Australian Science Writing. NewSouth. ISBN 9781742242231. Search this book on
  28. ↑ Prieve, Michael. "Celeb Snaps! Hottest Star Sightings — Monday, September 26, 2016 Celebuzz". www.celebuzz.com. Retrieved 30 September 2016.
  29. ↑ "2014 Science Communication Awards: The winning entries | AMRC - Association of Medical Research Charities". www.amrc.org.uk.
  30. ↑ "Researcher Hopeful, Sure of Future Cure for Huntington's Disease". Huntington's Disease News. BioNews Network. 22 July 2016.
  31. ↑ Wild, Edward J. (May 2016). "Huntington's Disease: The Most Curable Incurable Brain Disorder?". EBioMedicine. 8: 3–4. doi:10.1016/j.ebiom.2016.05.023.
  32. ↑ "Watch The Inheritance Online | Vimeo On Demand". Vimeo. Retrieved 2016-03-31.
  33. ↑ "Edward Wild". IMDb. Retrieved 4 May 2016.
  34. ↑ "Access to Understanding Science Writing Competition 2015" (PDF). Access to Understanding. Europe PubMed Central.
  35. ↑ "Huntington's And Immunity - Dr Ed Wild, University College London - The Naked Scientists". www.thenakedscientists.com. Retrieved 2016-04-01.
  36. ↑ "Listener Week. The Hayes Sisters; Huntington's Disease; Coping with the school holidays on a low income., Woman's Hour - BBC Radio 4". BBC. Retrieved 15 July 2016.
  37. ↑ "World-Renowned International Huntington Neurologists and Researchers to be featured at the Huntington Society of Canada's National Conference" (PDF). Huntington Society of Canada.
  38. ↑ "Carroll receives HDSA Researcher of the Year award | Western Today". westerntoday.wwu.edu. Retrieved 2016-03-31.

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