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Ensemble Therapeutics Corp.

From EverybodyWiki Bios & Wiki

Ensemble Therapeutics Corp.
IndustryHealth care
Fatepermanently closed
Founded 📆2004 (2004)
Founder 👔David R. Liu
Headquarters 🏙️, ,
United States
Area served 🗺️
Key people
Michael D. Taylor
Nick K. Terrett
Products 📟 Ensemblins™ (under development)
Number of employees
📇 Address
📞 telephone

Ensemble Therapeutics Corporation was a privately held pharmaceutical and biotechnology company located in Cambridge, Massachusetts. Founded in 2004 by Harvard chemist David R. Liu, the company attempted to develop and bring to market synthetic macrocycle drugs, that is, compounds with a characteristic macrocyclic ring structure, under the trademark Ensemblins. If successful, Ensemblins would be a new class of drugs, with some properties between small molecules and biologics. An orally active antagonist to Interleukin 17 has shown activity in animal models.[1]


John Ripple became chief executive officer in 2013. Nick K. Terrett has been the chief scientific officer since 2006. Founder David R. Liu chairs the scientific advisory board.[2]


Ensemble is principally owned by Flagship Ventures, a venture capital firm whose founder, Noubar Afeyan, chairs its board.[3] Other investors include ARCH Venture Partners, CMEA, Harris & Harris, Kisco Ltd., and Boston University. As of 2012, Ensemble has raised $38.5 million of equity financing.[1]


Ensemble has entered into partnerships that allow its macrocycle libraries to be accessed for the purpose of affinity screening drug discovery against targets that are otherwise difficult to address. Partner firms include Novartis, Alexion, Boehringer Ingelheim, Genentech, Bristol-Myers Squibb, and Pfizer.[4][5]


Ensemble Therapeutics has quietly ceased to exist in November 2017.[6]


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