G2
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G2 vaccine is a safety immune-activator drug could prevent as vaccine against COVID-19. The G2 ingredients originated in completely natural and harmless resources, have prepared from animal lipids with addition of some other materials. 1. All pharmacological studies, including: cytotoxicity, examination of the pathological effects on nine organs in mice, mutagenicity tests, amyloidosis, tissue culture andanimal studiesshowed no adverse effects. A detailed description of all reports is available. 2. Evaluation of the G2 vaccine effect on mouse cellular immune system using delayed hypersensitivity and blastogenesis assay showed that this vaccine is an immune system stimulator by stimulating T helper (Th-1) cells immune response. That stimulates and strengthens this immune response more than ten times. 3. Creating an animal model of breast cancer in mice and therapeutically studies have shown that G2 vaccine can make about 42% of mice completely cancer-free and significantly increase the life expectancy and survival. 4. Initial studies of the use of G2 vaccine in end-stage patients with various cancers showed that they had gone from complete treatment to control or no treatment. But almost all of these patients benefited from longer life expectancy and better quality of life. 5. One of the cancer patients with concomitant asthma, recovered from asthma following the injection of the G2 vaccine. 6. Three volunteer patients with chronic asthma were screened for the G2 vaccine followed by 12 injections that experienced 85% asthma recovery. 7. So, we went one step back and the studies of animal model of asthma (sensitivity) were examined in one research center in Urmia city and two centers in Mashhad city. All three studies showed that the G2 and G2F vaccines reduced serum IgE levels as well as Eos. Cell counts also elevatedfor Th-1 cells cytokines pattern, Significantly. 8. Phase I clinical trials of G2 vaccine in three healthy volunteers showed no adverse effects. 9. Phase II study of human studies of the G2 vaccine among 33 asthma and allergy patients in Tabriz city has been done by a colleague in his personal clinic. He reported that between 40% and 100% of illness improved and become healthy. A detailed report of the late Dr. Nasiri Khalaji is available. 10. The G2 and G2F vaccines of the immersion type (injectable oil type) vaccines were patented. 11. We presented these results to the Medical Ethics Committee of the Tehran Med. Sci., University. After two years, the committee authorized the study of the drug among asthmatic patients. 12. Phase III Clinical trials of the G2 vaccine in more than 160 asthmatic patients showed decreased serum IgE levels and Eos cell counts. Their breath problems were significantly reduced and the clinical symptoms of asthma patients showed about 70% improvement in patient satisfaction and their physician evaluation. The written report of the analysis of the findings was reflected in the research deputy of Tehran Medical Sciences of University. 13. Phase IV clinical trials of asthma patients continued until approximately one thousand asthma patients and confirmed the result of phase III. 14. Simultaneous evaluation of G2 vaccine in more than one hundred asthmatic children in Rasht city. These surveys were conducted in accordance with a contract with the Country Support of Charitable Association of Diabetic Patients (CSCADP) in Rasht city and the results showed that about 90% of children asthma recovered. (The letter of manager of CSCADP is available). (CSCADP is the biggest NGO with more than 3.5 million members in my country). 15. All human studies in asthma and allergies have shown that the G2 vaccine has no side effects. 16. At the same time, these studies were launched at one of Tehran Hospital of Immunology and Allergy Clinic and were offered one year of asthma and allergy immunotherapy services to asthma and allergy patients.
References[edit]
Boskabady MS, Neamati A, MohagheghHazrati S, Khakzad MR, Moosavi SH, Gholamnezhad Z. The preventive effects of natural adjuvants, G2 and G2F on tracheal responsiveness and serum IL-4 and IFN-c (th1/th2 balance) in sensitized guinea pigs. Clinics vol.69 no.7 São Paulo July 2014. https://doi.org/10.6061/clinics/2014(07)09 Hazrati SM, Aghazadeh J, Mohtarami F, Abouzari M, Rashidi A.Neuroimmunomodulation. 2006;13(4):205-8. Epub 2007 Mar 2. Immunotherapy of prolactinoma with a T helper 1 activator adjuvant and autoantigens: a case report. Kalavi K, Mohagheghhazrati S. Treatment of DFUs: an immunologic concern.Endocrinologys Conference, Dec 19–23, Cochin, India [Oral]. (Abstract). 5 Kalavi K, Maleki A, KalaviMergen, Hazrati SM. Kalavi K, Moradi A, Keshtkar A, Kalavi M, Namazi G, MohagheghHazrati S. Diabetic foot ulcers: a novel treatment strategy.Irn J Med hypothesis Ideas 2008;2:1–5..Can we prevent amputation by immunologic concern? Student conference, Oct 2009, Antwerp, Belgium [Oral]. (Abstract). Khodadadi A, Abdoli Z, Boroujerdnia MG, Assarehzadegan MA, Ghasemi M, Hazrati SM, Gerdabi ND. Cancer BiotherRadiopharm. 2016 May;31(4):119-24. doi: 10.1089/cbr.2015.1883.The Effect of G2 Adjuvant on Gene Expression and Delivery of NKG2D Receptor on NK Cells in Peripheral Blood.Original Article KiaSJ,Sahebjamee M., Mighani G., MohagheghHazrati S., Tohidastekrad Z., Vahedi M. Shiraz Univ Dent J 2011; Vol.11, 29-34. Supplement. The Impact of Immunotherapeutic G2 Vaccine on Treatment of Oral Lichen Planus. Document Type: Original Article Neamati A , Boskabady MH, MohagheghHazrati S , Khakzad MR, Moosav SH. Avicenna Journal of Phytomedicine 3(4):364-70 • June 2013. The effect of natural adjuvants (G2, G2F) on lung inflammation of sensitized guinea pigs. Neamati A, BoskabadyMH, Tabatabaei A, MohagheghHazrati S. Iran Red Crescent Med J. 2014 February; 16(2): e14267. DOI: 10.5812/ircmj.14267 Published online 2014 February 5. Research Article. The Effect of Natural Adjuvants on Pathological Changes in Sensitized Guinea Pig Lungs. Mirsadraee M, MohagheghHazratiS, Khakzad MR, Ghafarzadegan K, Boskabady MH. Iranian Journal of Basic Medical Sciences www.mums.ac.ir Vol. 15, No. 5, Sep-Oct 2012, 1068-1075 Dec 24, 2011 1068 Iran J Basic Med Sci, Vol. 15, No. 5, Sep-Oct 2012 Preventive Effect of Novel Bacterial Polysaccharide and Animal Splenic Protein as Natural Adjuvants on Animal Model of Asthma. Shafie S, Soltani E, Soltani M, HazratiMohaghehg S. Fish Shellfish Immunol. 2018 Nov;82:115-120. doi: 10.1016/j.fsi.2018.08.011. Epub 2018 Aug 7. Adjuvant efficacy of G2 (buffalo spleen extraction) against Yersinia septicemia in rainbow trout (Onchorhynchus mykiss).
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