Gabriel E. Pantelias
| Gabriel E. Pantelias | |
|---|---|
| Born | Greece |
| 🏳️ Nationality | Greek |
| 🎓 Alma mater | National and Kapodistrian University of Athens (BSc) University of Rochester (PhD) |
| 💼 Occupation | |
| Known for | Premature chromosome condensation (PCC) technique G2-assay for radiosensitivity prediction |
| 🏅 Awards | Bacq and Alexander Award (2020) George V. Metzger Award (1984) |
Gabriel E. Pantelias is a Greek radiobiologist and cytogeneticist known for his pioneering work in biological dosimetry, including the development of the premature chromosome condensation (PCC) assay and a standardized G2-assay for predicting individual radiosensitivity.[1] He is an Emeritus Director of Research at the Institute of Nuclear and Radiological Sciences, Technology, Energy & Safety (INRASTES) within the National Centre for Scientific Research "Demokritos" (NCSR Demokritos) in Athens, Greece.[2] Pantelias has authored over 110 peer-reviewed publications and received the Bacq and Alexander Award in 2020 from the European Radiation Research Society.[1]
Early life and education
Pantelias was born in Greece.[2] He earned a Bachelor of Science in Physics from the National and Kapodistrian University of Athens in 1974.[2][1] He obtained a Certificate of Specialization in Health Physics from NCSR Demokritos in 1976.[2] Pantelias received a Master of Science in Radiobiology and Health Physics in 1979.[2][1] He completed a PhD in Radiobiology and Biophysics from the University of Rochester School of Medicine and Dentistry in 1984.[2][1] He conducted postdoctoral research at the Laboratory of Radiobiology and Environmental Health at the University of California, San Francisco.[2][1]
Career
Pantelias served as an assistant professor at the Department of Radiation Oncology and Nuclear Medicine at Thomas Jefferson University Hospital in Philadelphia.[2][1] In 1986, he joined NCSR Demokritos, where he founded and directed the Health Physics, Radiobiology & Cytogenetics Laboratory until 2017.[2][1] He held positions as Vice President of NCSR Demokritos, Director of the Institute of Radioisotopes & Radiodiagnostic Products, and Director of INRASTES.[2][1] From 2005 to 2017, he was the Radiation Protection Officer at NCSR Demokritos.[2]
Pantelias served as a board member of the European Radiation Research Society from 2011 to 2017 and of the Greek Atomic Energy Commission from 2018 to 2020.[2][1] He has been an expert for the International Atomic Energy Agency (IAEA) on missions related to radiobiology, biodosimetry, and radiation protection.[2][1] He represented NCSR Demokritos in the Inter-University Post-Graduate Course in Medical Radiation Physics, coordinating radiation biology courses.[1] Pantelias has been involved in the RENEB (Realizing the European Network of Biodosimetry) project since 2012, contributing to standardization and interlaboratory exercises.[3] He has served as a reviewer for international journals and as principal investigator on numerous European and national research projects.[2][1]
Research
Pantelias's research focuses on the biological effects of ionizing radiation at the DNA, chromosomal, and cellular levels, including mechanisms of interaction, radiation-induced carcinogenesis, and chromothripsis.[2][1] He developed the PCC assay using G0-blood lymphocytes for biological dosimetry and risk assessment in radiation accidents, enabling rapid dose estimation in large-scale emergencies.[1][4] He also created a standardized G2-assay for predicting individual radiosensitivity.[1][5]
His work explores chromosome breakage, repair, and rearrangement; conversion of DNA damage into chromatid breaks; formation of chromosomal aberrations at various cell cycle stages; effects of different radiation qualities (including high-LET); non-targeted effects; genomic instability; and biomarkers for biodosimetry.[1] Recent studies focus on using PCC to unravel chromothripsis origins and fingerprints of high-LET irradiation.[1][6] Pantelias has published over 110 peer-reviewed articles and contributed to more than 170 international conference proceedings, with over 3,300 citations.[2][7] His collaborators include researchers from institutions such as the University of Texas MD Anderson Cancer Center, GSI Helmholtz Centre for Heavy Ion Research, and National Institutes for Quantum Science and Technology.[7]
Awards and recognition
Pantelias received the **George V. Metzger Award** in 1984 from the Department of Biochemistry & Biophysics at the University of Rochester for the quality of his doctoral dissertation and supporting research.[8] He received the Bacq and Alexander Award from the European Radiation Research Society in 2020 for his contributions to radiobiological sciences and radiation cytogenetics.[1][2] He has been awarded several scholarships, fellowships, honorary prizes, and distinctions for his education and scientific achievements.[1]
Selected publications
- Terzoudi GI, Pantelias GE (2020). "Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering—A Critical Risk for Chromothripsis". Cancers. 12(9):2336.[6]
- Terzoudi GI, Pantelias GE (2019). "Use of human lymphocyte G0 PCCs to detect intra- and inter-chromosomal aberrations for early radiation biodosimetry and retrospective assessment of radiation-induced effects". PLOS ONE. 14(5):e0216081.[9]
- Kulka U, et al. (2017). "RENEB – Running the European Network of biological dosimetry and physical retrospective dosimetry". International Journal of Radiation Biology. 93(1):2–14.[3]
- Terzoudi GI, et al. (2015). "Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis". Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 793:185–198.[10]
- Pantelias GE, Terzoudi GI (2011). "A standardized G2-assay for the prediction of individual radiosensitivity". Radiotherapy and Oncology. 101(1):28–34.[5]
- Pantelias GE, Maillie HD (1984). "The use of peripheral blood mononuclear cell prematurely condensed chromosomes for biological dosimetry". Radiation Research. 99(1):140–150.[4]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 "The Bacq and Alexander Award". European Radiation Research Society. Retrieved December 25, 2025.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 "Pantelias Gabriel - INRASTES". National Centre for Scientific Research "Demokritos". Retrieved December 25, 2025.
- ↑ 3.0 3.1 Kulka, U.; Wojcik, A.; Miura, T.; Vral, A.; et al. (2017). "RENEB – Running the European Network of biological dosimetry and physical retrospective dosimetry". International Journal of Radiation Biology. 93 (1): 2–14. doi:10.1080/09553002.2016.1230239. PMID 27686547. Unknown parameter
|DUPLICATE_last5=ignored (help);|Authors list=missing|5=(help) - ↑ 4.0 4.1 Pantelias, G.E.; Maillie, H.D. (1984). "The use of peripheral blood mononuclear cell prematurely condensed chromosomes for biological dosimetry". Radiation Research. 99 (1): 140–150. Bibcode:1984RadR...99..140P. doi:10.2307/3576452. JSTOR 3576452. PMID 6740072.
- ↑ 5.0 5.1 Pantelias, G.E.; Terzoudi, G.I. (2011). "A standardized G2-assay for the prediction of individual radiosensitivity". Radiotherapy and Oncology. 101 (1): 28–34. doi:10.1016/j.radonc.2011.09.021. PMID 22001115.
- ↑ 6.0 6.1 Terzoudi, G.I.; Pantelias, G.E. (2020). "Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering—A Critical Risk for Chromothripsis". Cancers. 12 (9): 2336. Bibcode:2020Cance..12.2336P. doi:10.3390/cancers12092336. PMC 7563219 Check
|pmc=value (help). PMID 32825347 Check|pmid=value (help). - ↑ 7.0 7.1 "Gabriel Pantelias". Retrieved December 25, 2025.
- ↑ "George V. Metzger Award". University of Rochester Medical Center. Retrieved December 25, 2025.
- ↑ Terzoudi, G.I.; Pantelias, G.E. (2019). "Use of human lymphocyte G0 PCCs to detect intra- and inter-chromosomal aberrations for early radiation biodosimetry and retrospective assessment of radiation-induced effects". PLOS ONE. 14 (5): e0216081. Bibcode:2019PLoSO..1416081R. doi:10.1371/journal.pone.0216081. PMC 6502328 Check
|pmc=value (help). PMID 31075152. - ↑ Terzoudi, G.I.; Karakosta, M.; Pantelias, A.; Hatzi, V.I.; Karachristou, I.; Pantelias, G. (2015). "Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis". Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 793: 185–198. Bibcode:2015MRGTE.793..185T. doi:10.1016/j.mrgentox.2015.07.014. PMID 26520384.
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