Gimantan
 | |
| Clinical data | |
|---|---|
| Synonyms | Hemantane, Himantane, A-7. |
| Identifiers | |
| PubChem CID | |
| ChemSpider | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}} |
| Chemical and physical data | |
| Formula | C16H27N |
| Molar mass | 233.399 g·mol−1 |
| 3D model (JSmol) | |
| |
Gimantan (Hemantane) is a Russian monoamine oxidase inhibitor. It has an adamantane amine molecular structure and is similar to related agents such as amantadine and memantine.
It is patented for the treatment of pain and inflammation,[1] alcoholism:[2] Cerebral circulation:[3] and Parkinson’s disease.[4]
The dosage is standardized to 50mg Tablets:[5]
Synthesis
Gimantan is synthesized, according to the Leuckart reaction, by heating adamantan-2-one and hexamethyleneimine in the presence of formic acid.[6][7][8]
References
- ↑ Елена Артуровна Вальдман, RU2559777C2 (2014).
- ↑ RU2582966C2
- ↑ RU2554502C2
- ↑ RU2423981C2
- ↑ Tsvetkova EA, Volkova MY, Stepanenko OB, Kislyak NA, Shcherbakova OV, Avdyunina NI, Pyatin BM (January 2002). "Gimantan Tablets: Analysis and Standardization". Pharmaceutical Chemistry Journal. 36 (1): 48–50. doi:10.1023/A:1015761110991.
- ↑ Sergeeva MS, Grushevskaya LN, Pyatin BM, Avdyunina NI, Gaevaya LM, Klumova VS, Dudenkova ME, Alekseev KV, Litvin EA (November 2011). "Pharmaceutical analysis and standardization of gimantan parenteral dosage form". Pharmaceutical Chemistry Journal. 45 (8): 499–502. doi:10.1007/s11094-011-0664-1.
- ↑ Seredenin SB, Voronina TA, Avdyunina NI, Pyatin BM, Morozov IS, Bykov NP, Nerobkova LN, Zinovieva IM, Klimova NV, Karadzhaev S, Markina NV (2010). "SU1825499 "N-(2-adamantyl)hexamethyleneimine hydrochloride with anticataleptic activity". Byull. Izobret. (in Russian). 4.CS1 maint: Unrecognized language (link)
- ↑ Tsvetkova EA, Volkova MY, Stepanenko OB, Avdyunina NI, Bol'shakova RF, Pyatin BM (November 2001). "Analysis and Standardization of the New Domestic Antiparkinsonian Drug Gimantan". Pharmaceutical Chemistry Journal. 35 (11): 635–638. doi:10.1023/A:1015158213734.
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