Gregg G. Gundersen
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| Gregg G. Gundersen | |
|---|---|
 Gregg G Gundersen.jpg | |
| Born | May 5, 1955 |
| 💼 Occupation | |
| Known for | Microtubule post-translational modifications, nuclear movement |
Gregg G. Gundersen is an American cell biologist and a faculty member in the Department of Pathology and Cell Biology at Columbia University.
Early life and education[edit]
Gundersen earned his PhD degree from the University of Washington in the lab of Bennett M Shapiro where he provided evidence that the sperm cell fusses its outer membrane with oocytes during fertilization.[1] He then went on to conduct a postdoctoral fellowship in the lab of his former wife, Jeannette Chloe Bulinski, at UCLA where he demonstrated that a subset of microtubules accumulate post-translational modifications.[2]. After a short postdoctoral fellowship at CalTech he and Bulinski moved to Columbia University where they took faculty positions in the departments of Anatomy and Cell Biology, and Pathology.
Career[edit]
Gundersen's work has focused on how the microtubule and actin cytokskeletons contribute to cell polarity in mammalian cells. His lab demonstrated that a subset of microtubules that are oriented towards the leading edge of migrating cells become stabilized by formins, and +TIP proteins, including EB1 and APC.[3][4] He also provided evidence that the LINC complex drives nuclear migration in polarized mammalian cells by connecting the nucleus to the actin cytoskeleton.[5][6] His lab has also made seminal advances in how the actin and microtubule cytoskeletons regulate cell attachments (also known as focal adhesions) to the extracellular matrix.[7][8]
External links[edit]
References[edit]
- ↑ Gundersen GG, Shapiro BM (1984). "Sperm surface proteins persist after fertilization". J Cell Biol. 99 (4 Pt 1): 1343–53. doi:10.1083/jcb.99.4.1343. PMC 2113326. PMID 6434548.
- ↑ Gundersen GG, Kalnoski MH, Bulinski JC (1984). "Distinct populations of microtubules: tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo". Cell. 38 (3): 779–89. doi:10.1016/0092-8674(84)90273-3. PMID 6386177.CS1 maint: Multiple names: authors list (link)
- ↑ Palazzo AF, Cook TA, Alberts AS, Gundersen GG (2001). "mDia mediates Rho-regulated formation and orientation of stable microtubules". Nat Cell Biol. 3 (8): 723–9. doi:10.1038/35087035. PMID 11483957.CS1 maint: Multiple names: authors list (link)
- ↑ Wen Y, Eng CH, Schmoranzer J, Cabrera-Poch N, Morris EJ, Chen M; et al. (2004). "EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration". Nat Cell Biol. 6 (9): 820–30. doi:10.1038/ncb1160. PMID 15311282.CS1 maint: Multiple names: authors list (link)
- ↑ Gomes ER, Jani S, Gundersen GG (2005). "Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells". Cell. 121 (3): 451–63. doi:10.1016/j.cell.2005.02.022. PMID 15882626.CS1 maint: Multiple names: authors list (link)
- ↑ Luxton GW, Gomes ER, Folker ES, Vintinner E, Gundersen GG (2010). "Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement". Science. 329 (5994): 956–9. doi:10.1126/science.1189072. PMC 3938394. PMID 20724637.CS1 maint: Multiple names: authors list (link)
- ↑ Smilenov LB, Mikhailov A, Pelham RJ, Marcantonio EE, Gundersen GG (1999). "Focal adhesion motility revealed in stationary fibroblasts". Science. 286 (5442): 1172–4. doi:10.1126/science.286.5442.1172. PMID 10550057.CS1 maint: Multiple names: authors list (link)
- ↑ Ezratty EJ, Partridge MA, Gundersen GG (2005). "Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase". Nat Cell Biol. 7 (6): 581–90. doi:10.1038/ncb1262. PMID 15895076.CS1 maint: Multiple names: authors list (link)
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