HIF strengthening factor
A HIF strengthening factor (HSF) is a molecule to stimulate the Hypoxia-inducible factor (HIF) signaling pathway.
The 2019 Nobel Prize in Physiology or Medicine was awarded for the discovery of HIF.[1] HIFs are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.[2] The hypoxia in wounds promotes the migration of keratinocytes and the restoration of the epithelium.[3] It is therefore not surprising that HIF-1 modulation was identified as a promising treatment paradigm in wound healing.[4] This insight led to the development of HIF Strengthening Factors (HSF) to induce repair, regeneration and rejuvenation.
Researchers at the Stanford University School of Medicine demonstrated that HIF-1 activation was able to prevent and treat chronic wounds in diabetic and aged mice.[5][6][7] Not only did the wounds in the mice heal more quickly, but the quality of the new skin was even better than the original.[8] Additionally the regenerative effect of HIF-1 modulation on aged skin cells was described[9] and a rejuvenating effect on aged facial skin via HSF treatment was demonstrated in patients.[10] HIF activation has also been linked to a beneficial effect on hair loss.[11][12]
References[edit]
- ↑ "The Nobel Prize in Physiology or Medicine 2019". NobelPrize.org. Retrieved 2020-12-17.
- ↑ Smith, Thomas G; Robbins, Peter A; Ratcliffe, Peter J (May 2008). "The human side of hypoxia-inducible factor". British Journal of Haematology. 141 (3): 325–334. doi:10.1111/j.1365-2141.2008.07029.x. ISSN 0007-1048. PMC 2408651. PMID 18410568.
- ↑ Benizri, E.; Ginouvès, A.; Berra, E. (2008-04-01). "The magic of the hypoxia-signaling cascade". Cellular and Molecular Life Sciences. 65 (7): 1133–1149. doi:10.1007/s00018-008-7472-0. ISSN 1420-9071. PMID 18202826. Unknown parameter
|s2cid=ignored (help) - ↑ Hong, Wan Xing; Hu, Michael S.; Esquivel, Mikaela; Liang, Grace Y.; Rennert, Robert C.; McArdle, Adrian; Paik, Kevin J.; Duscher, Dominik; Gurtner, Geoffrey C.; Lorenz, H. Peter; Longaker, Michael T. (2014-05-01). "The Role of Hypoxia-Inducible Factor in Wound Healing". Advances in Wound Care. 3 (5): 390–399. doi:10.1089/wound.2013.0520. ISSN 2162-1918. PMC 4005494. PMID 24804159.
- ↑ University, © Stanford; Stanford; California 94305 (2015-01-23). "Skin patch could help heal, prevent diabetic ulcers, study finds". Welcome to Bio-X. Retrieved 2020-12-17.
- ↑ Duscher, Dominik; Neofytou, Evgenios; Wong, Victor W.; Maan, Zeshaan N.; Rennert, Robert C.; Inayathullah, Mohammed; Januszyk, Michael; Rodrigues, Melanie; Malkovskiy, Andrey V.; Whitmore, Arnetha J.; Walmsley, Graham G. (2015-01-06). "Transdermal deferoxamine prevents pressure-induced diabetic ulcers". Proceedings of the National Academy of Sciences of the United States of America. 112 (1): 94–99. Bibcode:2015PNAS..112...94D. doi:10.1073/pnas.1413445112. ISSN 0027-8424. PMC 4291638. PMID 25535360.
- ↑ Bonham, Clark A.; Rodrigues, Melanie; Galvez, Michael; Trotsyuk, Artem; Stern-Buchbinder, Zachary; Inayathullah, Mohammed; Rajadas, Jayakumar; Gurtner, Geoffrey C. (May 2018). "Deferoxamine Can Prevent Pressure Ulcers and Accelerate Healing in Aged Mice". Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 26 (3): 300–305. doi:10.1111/wrr.12667. ISSN 1067-1927. PMC 6238634. PMID 30152571.
- ↑ Duscher, Dominik; Trotsyuk, Artem A.; Maan, Zeshaan N.; Kwon, Sun Hyung; Rodrigues, Melanie; Engel, Karl; Stern-Buchbinder, Zachary A.; Bonham, Clark A.; Barrera, Janos; Whittam, Alexander J.; Hu, Michael S. (2019-08-28). "Optimization of transdermal deferoxamine leads to enhanced efficacy in healing skin wounds". Journal of Controlled Release. 308: 232–239. doi:10.1016/j.jconrel.2019.07.009. ISSN 0168-3659. PMID 31299261.
- ↑ Pagani, Andrea; Kirsch, B. Manuela; Hopfner, Ursula; Aitzetmueller, Matthias M.; Brett, Elizabeth A.; Thor, Dominik; Mela, Petra; Machens, Hans-Guenther; Duscher, Dominik (2020). "Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1α Modulation". Aesthetic Surgery Journal. doi:10.1093/asj/sjaa142. PMID 32479616 Check
|pmid=value (help). - ↑ Duscher, Dominik; Maan, Zeshaan N.; Hu, Michael S.; Thor, Dominik (November 2020). "A single-center blinded randomized clinical trial to evaluate the anti-aging effects of a novel HSF™-based skin care formulation". Journal of Cosmetic Dermatology. 19 (11): 2936–2945. doi:10.1111/jocd.13356. ISSN 1473-2165. PMID 32306525 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Houschyar, Khosrow Siamak; Borrelli, Mimi R.; Tapking, Christian; Popp, Daniel; Puladi, Behrus; Ooms, Mark; Chelliah, Malcolm P.; Rein, Susanne; Pförringer, Dominik; Thor, Dominik; Reumuth, Georg (2020). "Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms". Dermatology. 236 (4): 271–280. doi:10.1159/000506155. ISSN 1018-8665. PMID 32163945 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Bukowiecki, Julia; Pförringer, Dominik; Thor, Dominik; Duscher, Dominik; Brett, Elizabeth (2020-12-16). "HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth". Skin Pharmacology and Physiology: 1–8. doi:10.1159/000512123 (inactive 2021-01-05). ISSN 1660-5535. PMID 33326985 Check
|pmid=value (help).
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