Hosea M. Nelson

Hosea M. Nelson
HoseaNelson2.jpg HoseaNelson2.jpg
Born	(1977-09-15) September 15, 1977
🏳️ Nationality	American
🎓 Alma mater	University of California at Berkeley (B.S., 2004) California Institute of Technology (Ph.D., 2012)
💼 Occupation
Known for	Total synthesis of a class of medicinally relevant molecules derived from Thapsia
🌐 Website	http://www.thenelsonlab.com/members1.html

Hosea M. Nelson (born September 15, 1977) is an Assistant Professor or Chemistry at University of California, Los Angeles.

Prof. Nelson earned a B.S. in Chemistry from University of California at Berkeley in 2004 and a  Ph.D. from the California Institute of Technology in 2012. After postdoctoral training at University of California at Berkeley, Prof. Nelson joined the UCLA faculty in 2015.

Hosea Nelson is best known for his research in the area of synthetic organic chemistry and for pioneering efforts in the elucidation of small molecule structures by an electron diffraction technique known as microED.

Awards and Honors

• Novartis Excellence in Chemistry Award 2020
• ACS Aurthur C. Cope Scholar Award 2020
• National Organic Symposium (NOS) ACS Young Investigator, 2019
• UCLA Herbert C. McCoy Research Award, 2019
• NIH Early Stage Investigator Maximizing Investigators' Research Award (MIRA) (R35), 2018
• Alfred P. Sloan Fellowship, 2018
• UCLA Herbert C. McCoy Research Award, 2018
• David and Lucile Packard Fellowship for Science and Engineering, 2017
• UCLA Faculty Career Development Award, 2016
• C&EN Talented Twelve, 2015
• National Science Foundation Predoctoral Fellowship, 2007-2013
• Ford Foundation Diversity Fellowship, 2007-2013
• National Institutes of Health Bridges to Bacuealeate Undergraduate Research Fellowship, 2002
  

Publications

• Isolation and X-ray Crystal Structure of an Electrogenerated TEMPO-N3 Charge-Transfer Complex Nelson, H. M.; Siu, J. C.; Saha, A.; Cascio, D.; MacMillan, S. N.; Wu, S. B.; Lu, C.; Rodriguez, J. A.; Houk, K. N.; Lin, S. Org. Lett. 2021, 2, 454–458.
• Elucidation of Diverse Solid-State Packing in a Family of Electron-Deficient Expanded Helicenes via Microcrystal Electron Diffraction (MicroED)  Samkian, A.; Kiel, G. R.; Jones, C. G.; Bergman, H.; Oktawiec, J.; Nelson, H. M.; Tilley, T. D. Angew. Chem. Int. Ed. 2020, 5, 2493–2499.
• Chemocatalytic Amplification Probes Enable Transcriptionally-Regulated Au(I)-Catalysis in E. coli and Sensitive Detection of SARS-CoV-2 RNA Fragments  Green, S.; Wigman, B. W.; Nistanaki, S. K.; Montgomery, H.; Jones, C. G.; Nelson, H. M. ChemRxiv Preprint.
• Identification of Uric Acid Gluconucleoside–Ascaroside Conjugates in Caenorhabditis elegans by Combining Synthesis and MicroED  Curtis, B. J.; Kim, L. J.; Wrobel, C. J. J.; Eagen, J. M.; Smith, R. A.; Burch, J. E.; Le, H. H.; Artyukhin, A. B.; Nelson, H. M.; Schroeder, F. C. Org. Lett. 2020, ASAP.
• Structural Determination of an Orphan Natural Product Using Microcrystal Electrion Diffraction and Genome Mining  Kim, L. J.; Ohashi, M.; Tan, D.; Asay, M.; Cascio, D.; Rodriguez, J; Tang, Y.; Nelson, H. M. ChemRxiv Preprint.
• Terpene Tail-to-Head Polycyclization Mediated by Small Molecule Catalysts: A Weakly-Coordinating Anion Approach Burch, J. E.; Bagdasarian, A. L.; Hooshmand, T.; Nelson, H. M. ChemRxiv Preprint.
• Urea-Catalyzed Vinyl Carbocation Formation Enables Mild Functionalization of Unactivated C-H Bonds  Bagdasarian, A. L.; Popov, S.; Wigman, B.; Wei, W.; Lee, W.; Nelson, H. M. Org. Lett. 2020, ASAP.
• Dewar Heterocycles as Versatile Monomers for Ring-Opening Metathesis Polymerization  Nistanaki, S. K.; Nelson, H. M. ACS Macro Lett. 2020, 9, 731–735.
• Vinyl Carbocations Generated under Basic Conditions and Their Intramolecular C–H Insertion Reactions  Wigman, B.; Popov, S.; Bagdasarian, A. L.; Shao, B.; Benton, T. R.; Williams, C. G.; Fisher, S. P.; Lavallo, V.; Houk, K. N.; Nelson, H. M. J. Am. Chem. Soc. 2019, 141, 9140–9144.
• Characterization of reactive organometallic species via MicroED  Jones, C. G.; Asay, M.; Kim, L. J.; Kleinsasser, J. F.; Saha, A.; Fulton, T. J.; Berkly, K. R.; Cascio, D.; Malyutin, A. G.; Conley, M. P.; Stoltz, B. M.; Lavallo, V.; Rodriguez, J. A.; Nelson, H. M. ACS Cent. Sci. 2019, 5, 1507–1513.
• Regulating Transition Metal Catalysis Through Interference by Short RNAs  Green, S. A.; Montgomery, H. R.; Benton, T. R.; Chan, N. J.; Nelson, H. M. Angew. Chem. Int. Ed. 2019, 58,16400–16404.
• Nonclassical Applications of closo-Carborane Anions: From Main Group Chemistry and Catalysis to Energy Storage  Fisher, S. P.; Tomich, A. W.; Lovera, S. O.; Kleinsasser, J. F.; Guo, J.; Asay, M. J.; Nelson, H. M.; Lavallo, V. Chem. Rev. 2019, 119, 8262–8290.
• A Concise Total Synthesis of (±)-Vibralactone  Nistanaki, S. K.; Boralsky, L. A.; Pan, R. D.; Nelson, H. M. Angew. Chem. Int. Ed. 2019, 58, 1724–1726.
• The CryoEM method MicroED as a powerful tool for small molecule structure determination Jones, C. G.; Martynowycz, M. W.; Hattne, J.; Fulton, T. J.; Stoltz, B. M.; Rodriguez, J. A.; Nelson, H. M.; Gonen, T. ACS Cent. Sci. 2018, 4, 1587–1592.  
• Teaching an old carbocation new tricks: Intermolecular C–H insertion reactions of vinyl cations  Popov, S.; Shao, B.; Bagdasarian, A. L.; Benton, T. R.; Zhou, L.; Yang, Z.; Houk, K. N.; Nelson, H. M. Science 2018, 361, 381-387.
• Arylation of Hydrocarbons Enabled by Organosilicon Reagents and Weakly Coordinating Anions  Shao, B.‡;  Bagdasarian, A. L.‡; Popov, S.; Nelson, H. M. Science 2017, 355, 1403–1407.
• Enantioselective Heck–Matsuda Arylations through Chiral Anion Phase-Transfer of Aryl Diazonium Salts  Avilan C. M.; Patel, J. S.; Reddi, Y.; Saito, M.; Nelson, H. M.; Shunatona, H. P.; Sigman, M. S.; Sunoj, R. B.; Toste, F. D. Angew. Chem. Int. Ed. 2017, 56, 1–7.
• Enantioselective 1,1-Arylborylation of Alkenes: Merging Chiral Anion Phase Transfer with Pd Catalysis  Nelson, H. M.‡; Williams, B. D.‡; Miró, J.; Toste, F. D. J. Am. Chem. Soc. 2015, 137, 3213–3216.
• The Total Syntheses of Basiliolide C, epi-Basiliolide C, and Protecting-Group-Free Total Syntheses of Transtaganolides C and D  Gordon, J. R.; Nelson, H. M.; Virgil, S. C.; Stoltz, B. M.  J. Org. Chem. 2014, 79, 9740–9747.
• Enantioselective α-Amination Enabled by a BINAM-Derived Phase-Transfer Catalyst  Nelson, H. M.‡; Patel, J. S.‡; Shunatona, H. P.; Toste, F. D. Chem. Sci. 2015, 6, 170–173.
• Chiral Anion Phase-Transfer of Aryldiazonium Cations: An Enantioselective Synthesis of C3-Diazenated Pyrroloindolines  Nelson, H. M.; Reisberg, S. H.; Shunatona, H. P.; Patel, J. S.; Toste, F. D. Angew. Chem. Int. Ed. 2014, 53, 5600–5603.
• Selective Nucleic Acid Capture With Shielded Covalent Probes  Vieregg, J. R.; Nelson, H. M.; Stoltz, B. M.; Pierce, N. A. J. Am. Chem. Soc. 2013, 135, 9691–9699.
• Total Syntheses of (–)-Transtaganolide A, (+)-Transtaganolide B, (+)-Transtaganolide C, and (–)-Transtaganolide D and Biosynthetic Implications  Nelson, H. M.; Gordon, J. R.; Virgil, S. C.; Stoltz, B. M. Angew. Chem. Int. Ed. 2013, 52, 6699–6703.
• A General Approach to the Basiliolide/Transtaganolide Natural Products: Total Syntheses of Basiliolide B, epi-8-Basiliolide B, Transtaganolide C, and Transtaganolide D  Nelson, H. M.; Murakami, K.; Virgil, S. C.; Stoltz, B. M. Angew. Chem., Int. Ed. 2011, 50, 3688–3691.
• Progress Toward the Synthesis of the Transtaganolide/Basiliolide Natural Products: An Ireland-Claisen Approach  Nelson, H. M.; Stoltz, B. M. Tetrahedron Lett.  2009, 50, 1699–1701.
• Side Chain Chemistry Mediates Backbone Fragmentation in Hydrogen Deficient Peptide Radicals  Sun, Q.; Nelson, H. M.; Ly, T.; Stoltz, B. M.; Julian, R. R.  J. Proteome Res. 2009, 8, 958–966.
• Progress toward the Synthesis of the Basiliolides and Transtaganolides: An Intramolecular Pyrone Diels-Alder Entry into a Novel Class of Natural Products  Nelson, H. M.; Stoltz, B. M. Org. Lett. 2008, 10, 25–28.

References

• "The Nelson Group". thenelsonlab.com. Retrieved 2021-02-16.
• "Nelson, Hosea | UCLA Chemistry and Biochemistry". ucla.edu. Retrieved 2020-02-16.
• "Hosea Nelson – Talented 12". cenmag.org. Retrieved 2020-02-16.
• "‪Hosea Nelson‬ - ‪Google Scholar". scholar.google.com. Retrieved 2020-02-16.

External links

• Hosea's research group at UCLA
• Hosea Nelson and Jose Rodriguez, professors of chemistry and biochemistry at UCLA
• Hosea Nelson — Confessions of a Carbocation Addict
• C&EN talks with Hosea Nelson

Category:Living people Category:21st-century American chemists Category:1977 births

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