Innovative Bioresearch Ltd
Innovative Bioresearch Ltd is a biotech company using blockchain technology for introducing innovation in the pharma industry, founded by Italian entrepreneur and research scientist Jonathan Fior.[1][2][3] As such, they are developing traditional biomedical research in the field of vaccine development, especially for HIV and cancer, as well as real world use applications for blockchain technology in biomedical research with products such as a decentralized cryptocurrency and DApps (decentralized applications).[1][2]
Biomedical Research[edit]
HIV CURE RESEARCH[edit]
One of the main developments of the company's work in the HIV research field is the development of "SupT1 cell infusion therapy",[4] a novel cell based therapy for HIV using a permissive T cell line such as the SupT1 cell line as a "decoy target" for the virus, based on the research developed by research scientist Jonathan Fior[5][6][7]. It was observed that long term replication of the virus in SupT1 cells renders the virus significantly less virulent and as the virus adapts to replicate in these cells, viral evolution induces the HIV virus to generate less cytopathic effects on the host cells, and this phenomenon is explained as the virus untimate goal is not to kill the host but rather establishing a pacific coexistance that will allow both the host and virus survival, as it happens in natural non-human primate hosts of simian immunodeficiency virus.[8] Such a pacific coexistance is not possible with human cells, given that they are not very permissive to the HIV virus and this introduces viral evolution pressure inducing the virus to become more aggressive, especially when subject to antiretroviral treatment with HIV drugs. Therefore, Jonathan Fior proposed to use SupT1 cells as a permissive subset of cells to restrict HIV replication in order to induce a similar scenario observed in natural SIV hosts where the HIV infection does not induce the development of the associated immunodeficiency syndrome (AIDS), proposing the injection of such cells as a cell based therapy.[8] This approach was first investigated in vitro in a 2012 study [9] and tthen in vivo in a 2016 study using humanized mice.[4] In order to ensure safe inoculation of SupT1 cells, such cells are irradiated prior to inoculation according to cancer vaccination protocols, which resulted in no toxicity scored in the mice treated with SupT1 cell infusion.[4] The study also reported statistically significant reduced viral load and increased surviral of T cells during week 1 of treatment, with an animal exhibiting total virus eradication.[9] The author suggested that irradiating the cells may be a way to "trap" the virus which remains confined into SupT1 cells without spreading and replicating in normal T cells.[9] SupT1 cell infusion therapy is expected to be significanly cheaper than traditional antiretroviral therapy.[10]
CANCER AND REGENERATION RESEARCH[edit]
The company released in 2014 a peer reviewed scientific paper in which they discuss salamander regeneration as a model for developing innovative therapies for cancer as well as regenerative medicine.[11] Interestingly, they propose the idea that cancer is the result of a lost regenerative capacity during evolution that also induced the loss of all those pathways responsible for controlling the regeneration process, which causes cancer as an uncontrolled regeneration process that is normally latent and inactive.[11] As such, they compare salamander regeneration process with human healing, and review the present literature on studies showing that the advanced salamander regeneration process can in fact induce cancer healing in those animals, which have the unique ability among vertebrates to regenerate entire limbs, self heal induced tumors, as well as scarless healing.[11]
Blockchain Implementations[edit]
INNOVATIVE BIORESEACH COIN (INNBC)[edit]
During 2018, Innovative Bioresearch Ltd issued InnovativeBioresearchCoin (INNBC),[12][13] a decentralized crypto token running on the etherum blockchain. INNBC is serving as a digital payment system to access all the products and services developed by Innovative Bioresearch Ltd, as well as supporting their development. As such, INNBC is a "DeSci" (decentralized science} token, decentralizing several aspects of biomedical research, from the funding of the research itself, to the sharing of the scientific data.[12]
INNBC SCIENTIFIC DAPP[edit]
During 2021, Innovative Bioresearch issued INNBC DApp,[14] their first DApp for science, providing a simple and straightforward interface to record biomedical data on chain using a smart contract deployed on the BNB smart chain blockchain initially due to the lower fees compared to the etherum blockchain. The company also produced a scientific paper on its real world use for recording on chain biomedical data, currently under review on the PlosONE scientific journal,[15] introducing the scientific peer reviewed standard for the first time in a crypto project. The DApp allows to easily record data such as text, and also images, audio and video can be easily recorded on chain using Base64 encoding. The main use case for biomedical data is to generate a permanent and immutable record of scientific data taking advantage of specific blockchain features such as timestamp and immutability. In addition to record biomedical data, the DApp is also proposed as a decentralized storage solution for general purpose data.[14] This can be especially useful for protecting intellectual property.
INNBC SWAP DEX DAPP[edit]
During 2022, Innovative Bioresearch issued INNBC Swap DEX,[16] the company own decentralized exchange DApp, in order to allow users to swap the INNBC token in a trustless and permissionless environment, in which instead of having to trust a centralized platform to hold their funds, everything is managed by a decentralized smart contract. INNBC Swap Dex also integrates access to Uniswap V3 liquidity pools, allowing users to provide liquidity at specific price ranges.[16]
External Links[edit]
INNBC Decentralized Exchange DApp
This article "Innovative Bioresearch Ltd" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Innovative Bioresearch Ltd. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
- ↑ 1.0 1.1 Desk, CryptoTrends. "Innovative Bioresearch Aims To Disrupt Pharma". CryptoTrends. Retrieved 2022-07-03.
- ↑ 2.0 2.1 "Recording Biomedical Data on Chain is now Possible — Interview with the CEO of Innovative Bioresearch and INNBC Token". bitcourier.co.uk. Retrieved 2022-07-03.
- ↑ Newsbit (2020-07-11). "Wat is Innovative Bioresearch?". Newsbit (in Nederlands). Retrieved 2022-07-05.
- ↑ 4.0 4.1 4.2 Fior, Jonathan (2016-04-26). "SupT1 Cell Infusion as a Possible Cell-Based Therapy for HIV: Results from a Pilot Study in Hu-PBMC BRGS Mice". Vaccines. 4 (2): E13. doi:10.3390/vaccines4020013. ISSN 2076-393X. PMC 4931630. PMID 27128948.
- ↑ "Innovative Bioresearch Announces Publication of Pioneering Pilot Study Exploring SupT1 Cell Infusion as a Cell-Based Therapy for HIV in Humanized Mice". wallstreet-online.de (in Deutsch). 2016-04-26. Retrieved 2022-07-05.
- ↑ "Innovative Bioresearch announces publication of pioneering pilot study exploring SupT1 cell infusion as a cell-based therapy for HIV in humanized mice". Medical News Today. Retrieved 2022-07-05.
- ↑ Martin, Ulrich. "The Biologics News and Reports Portal". pipelinereview. Retrieved 2022-07-05.
- ↑ 8.0 8.1 Fior, Jonathan (2013-02-21). "Is a pacific coexistence between virus and host the unexploited path that may lead to an HIV functional cure?". Viruses. 5 (2): 753–757. doi:10.3390/v5020753. ISSN 1999-4915. PMC 3640524. PMID 23430684.
- ↑ 9.0 9.1 9.2 Fior, Jonathan (2012). "An initial in vitro investigation into the potential therapeutic use of SupT1 cells to prevent AIDS in HIV-seropositive individuals". PLOS ONE. 7 (5): e37511. Bibcode:2012PLoSO...737511F. doi:10.1371/journal.pone.0037511. ISSN 1932-6203. PMC 3359297. PMID 22701517.
- ↑ Newsbit (2020-07-11). "Wat is Innovative Bioresearch?". Newsbit (in Nederlands). Retrieved 2022-07-04.
- ↑ 11.0 11.1 11.2 Fior, Jonathan (2014). "Salamander regeneration as a model for developing novel regenerative and anticancer therapies". Journal of Cancer. 5 (8): 715–719. doi:10.7150/jca.9971. ISSN 1837-9664. PMC 4174516. PMID 25258653.
- ↑ 12.0 12.1 "HIV And Cancer Research | Innovative Bioresearch Ltd | INNBC crypto token". INNBC. Retrieved 2022-07-04.
- ↑ "Innovative Bioresearch Coin price today, INNBC to USD live, marketcap and chart". CoinMarketCap. Retrieved 2022-07-04.
- ↑ 14.0 14.1 Bioresearch, Innovative (2021-06-08). "Innovative Bioresearch Launches the First Decentralized Database DApp for Biomedical Data". INNBC. Retrieved 2022-07-04.
- ↑ Bioresearch, Innovative (2022-04-19). "New study sent for peer review on PlosONE". INNBC. Retrieved 2022-07-04.
- ↑ 16.0 16.1 Bioresearch, Innovative (2022-06-08). "We Launched INNBC Swap Dex, our decentralized exchange featuring Uniswap V3 liquidity pools". INNBC. Retrieved 2022-07-04.
