Jared Roach
| Jared Roach | |
|---|---|
| File:Jared Roach, MD, PhD, Senior Scientist at the Institute for Systems Biology.jpgJared Roach, MD, PhD, Senior Scientist at the Institute for Systems Biology.jpg Roach in 2011 | |
| Born | |
| 🏳️ Citizenship | United States |
| 🎓 Alma mater | University of Washington Cornell University |
| 💼 Occupation | |
| Known for | Pairwise End Sequencing, Systems Biology, Human Genome Project |
| 🌐 Website | strategicgenomics |
Jared C. Roach is an American biologist who introduced the pairwise end sequencing strategy while at the University of Washington.[1][2]
Education and early career[edit]
Roach attended Cornell University, where he received his Bachelor of Science in Biology in 1990. He then attended the University of Washington, where he received his PhD in Immunology in 1998, and his MD in 1999. He trained in Internal Medicine at the University of Utah through 2001.[3]
Career[edit]
Starting as graduate student in the 1990s, Roach worked on the Human Genome Project from its early days through the end of the project.[4] Roach contributed strategic and algorithmic designs to the Human Genome Project, including the pairwise end-sequencing strategy.[5]
Roach was a Senior Fellow at the Department of Molecular Biotechnology at the University of Washington from 1999-2000. In 2001, he became a Research Scientist at the Institute for Systems Biology.[6]
In 2009, Roach was a leader of a team that sequenced the whole genomes of a human family of four.[7] This effort identified the cause of Miller syndrome, a simple recessive Mendelian disorder.[8] The team established the mutation rate in humans for the first time by direct observation.(in which paper, what is it, and how is it more "direct" than other estimates?) It also produced the first complete whole-chromosomal haplotypes in humans.[3] ( Is your reference a newsletter, or a peer-reviewed journal? What's the link? But I think you mean https://www.biorxiv.org/content/10.1101/629337v2.full ) The team applied these techniques to identify the causes of several Mendelian diseases, including genes for Adams-Oliver syndrome, alternating hemiplegia of childhood, epilepsy, pityriasis, and Fanconi anemia.(refs for each please)
Roach was Scientific Director of the High-throughput Data Analysis Laboratory at Seattle Children’s Research Institute from 2007 to 2009. Since 2009, Roach has served as a Senior Research Scientist at the Institute for Systems Biology. (ref)
Roach's group currently applies systems biology and genomics to complex diseases. (which besides Alzheimers?) The group also develops new (jargon) systems-biology and statistical approaches to integrate high-throughput datasets.(which) The group focuses on the systems biology architecture of Alzheimer’s disease.[9]
In 2020, Roach worked on the molecular phylogenetics of SARS-CoV-2,[10] (and so did every molecular biologist in the world) including identification of a case of COVID-19 re-infection.[11]
Selected Writing[edit]
Roach has over 80 publications with over 8000 citations. He has also translated a book on the Asian game of Go.[12] Selected publications include:
- Roach, Boysen, Wang, Hood. 1995. Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics 26:345-353.[13](171 citations)
- Roach. 1995. Random subcloning. Genome Research 5:464-473.[14] (35 citations)
- Roach, Glusman, Hubley, Montsaroff, Holloway, Mauldin, Srivastava, Garg, Pollard, Galas, Hood, Smit. 2011. Chromosomal Haplotypes by Genetic Phasing of Human Families. AJHG 89(3):382-97.[15] (56 citations)
- Roach, Glusman, Smit, Huff, Hubley, Shannon, Rowen, Pant, Goodman, Bamshad, Shendure, Drmanac, Jorde, Hood, Galas. Analysis of genetic inheritance in a family quartet by whole genome sequencing. 2010. Science 328(5978):636-9.[16] (1090 citations)
- Aparicio, S., Chapman, J., Stupka, E., Putnam, N., Chia, JM., Dehal, P., Christoffels, A., Rash, S., Hoon, S., Smit, A., Gelpke, M. D., Roach, J., Oh, T., Ho, I. Y., Wong, M., Detter, C., Verhoef, F., Predki, P., Tay, A., Lucas, S., Richardson, P., Smith, S. F., Clark, M. S., Edwards, Y. J., Doggett, N., Zharkikh, A., Tavtigian, S. V., Pruss, D., Barnstead, M., Evans, C., Baden, H., Powell, J., Glusman, G., Rowen, L., Hood, L., Tan, Y. H., Elgar, G., Hawkins, T., Venkatesh, B., Rokhsar, D., and Brenner, S. 2002. Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science297(5585):1301-1310.[17] (1677 citations)
- Roach, J. C., Glusman, G., Rowen, L., Kaur, A., Purcell, M. K., Smith, K. D., Hood, L., and Aderem, A. 2005. The evolution of vertebrate toll-like receptors. Proc Natl Acad Sci U S A 102(27):9577-9582.[18] (1187 citations)
Service[edit]
Roach was a founding member of the international Bipolar Sequencing Consortium.[19] He is a member and chair of the California Institute for Regenerative Medicine's Grants Working Group. [20]
Awards[edit]
Roach's work on sequencing a human family was named one of the top ten scientific discoveries of 2010 by Discover Magazine.[21] (are they a Reliable source for such a statement?)
And, refs 4, 8 & 9 are not Reliable sources for this subject. 6 & 11 are not peer-reviewed sources. 2 is a mention. 6 is not a 3rd party source, because its what you said in an interview
References[edit]
- ↑ Xiao W, Wu L, Yavas G, Simonyan V, Ning B, Hong H (2016). "Challenges, Solutions, and Quality Metrics of Personal Genome Assembly in Advancing Precision Medicine". Pharmaceutics. 8 (2). doi:10.3390/pharmaceutics8020015. PMC 4932478. PMID 27110816.CS1 maint: Multiple names: authors list (link)
- ↑ Timmerman, Luke (August 10, 2016). Hood: Trailblazer of the Genomics Age. Bandera Press. p. 265. ISBN 978-0997709308. Search this book on
- ↑ 3.0 3.1 Vence, Tracy (November 2011). "Genome analysis: With New Algorithm, Researchers Generate Haplotypes for Two Families". Genome Technology. November 2011.
- ↑ Scher, Steve (October 24, 2011). "Genomes and Future Technology". Weekday. NPR. KUOW.
- ↑ Roach, Jared (1995). "Pairwise end sequencing: a unified approach to genomic mapping and sequencing". Genomics. 26 (2): 345–353. doi:10.1016/0888-7543(95)80219-C. PMID 7601461.
- ↑ "ISB's Jared Roach on Why Two Technologies Are Better than One". GenomeWeb. June 8, 2005. Retrieved October 23, 2020.
- ↑ Wade, Nicholas (March 11, 2010). "Disease Cause is Pinpointed with Genome". New York Times. p. 1.
- ↑ Stewart, Kirsten (March 10, 2010). "Unraveling one family's genome". The Salt Lake Tribune.
- ↑ "Multimodal Prevention and Treatment of Alzheimer's Disease". Rotary Club of Bellevue. Retrieved Aug 1, 2020.
- ↑ Doughton, Sandi (May 26, 2020). "New analysis may rewrite the history of Washington state's coronavirus outbreak". Seattle Times.
- ↑ "Seattle, Washington patient is reinfected by COVID-19". Digital Journal. Toronto, Canada. October 1, 2020. Retrieved October 2, 2020.
- ↑ Lim, Eugene; Dickey, Herve (2004). Mastering the Basics of Go. Translated by Roach, Jared. Slate and Shell. ISBN 978-1932001181. Search this book on
- ↑ Roach, J. C.; Boysen, C.; Wang, K.; Hood, L. (1995). "Pairwise end sequencing: A unified approach to genomic mapping and sequencing". Genomics. 26 (2): 345–53. doi:10.1016/0888-7543(95)80219-c. PMID 7601461.
- ↑ Roach, J. C. (1995). "Random subcloning". Genome Research. 5 (5): 464–73. doi:10.1101/gr.5.5.464. PMID 8808467.
- ↑ Roach, J. C.; Glusman, G.; Hubley, R.; Montsaroff, S. Z.; Holloway, A. K.; Mauldin, D. E.; Srivastava, D.; Garg, V.; Pollard, K. S.; Galas, D. J.; Hood, L.; Smit, A. F. (2011). "Chromosomal haplotypes by genetic phasing of human families". American Journal of Human Genetics. 89 (3): 382–97. doi:10.1016/j.ajhg.2011.07.023. PMC 3169815. PMID 21855840.
- ↑ Roach, J. C.; Glusman, G.; Smit, A. F.; Huff, C. D.; Hubley, R.; Shannon, P. T.; Rowen, L.; Pant, K. P.; Goodman, N.; Bamshad, M.; Shendure, J.; Drmanac, R.; Jorde, L. B.; Hood, L.; Galas, D. J. (2010). "Analysis of genetic inheritance in a family quartet by whole-genome sequencing". Science. 328 (5978): 636–9. Bibcode:2010Sci...328..636R. doi:10.1126/science.1186802. PMC 3037280. PMID 20220176.
- ↑ Aparicio, S.; Chapman, J.; Stupka, E.; Putnam, N.; Chia, J. M.; Dehal, P.; Christoffels, A.; Rash, S.; Hoon, S.; Smit, A.; Gelpke, M. D.; Roach, J.; Oh, T.; Ho, I. Y.; Wong, M.; Detter, C.; Verhoef, F.; Predki, P.; Tay, A.; Lucas, S.; Richardson, P.; Smith, S. F.; Clark, M. S.; Edwards, Y. J.; Doggett, N.; Zharkikh, A.; Tavtigian, S. V.; Pruss, D.; Barnstead, M.; et al. (2002). "Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes". Science. 297 (5585): 1301–10. Bibcode:2002Sci...297.1301A. doi:10.1126/science.1072104. PMID 12142439. Unknown parameter
|s2cid=ignored (help) - ↑ Roach, J. C.; Glusman, G.; Rowen, L.; Kaur, A.; Purcell, M. K.; Smith, K. D.; Hood, L. E.; Aderem, A. (2005). "The evolution of vertebrate Toll-like receptors". Proceedings of the National Academy of Sciences of the United States of America. 102 (27): 9577–82. Bibcode:2005PNAS..102.9577R. doi:10.1073/pnas.0502272102. PMC 1172252. PMID 15976025.
- ↑ "Bipolar Seqeuncing Consortium". BSC. Retrieved September 18, 2020.
- ↑ "Grants Review Working Group Members". CIRM. Retrieved September 18, 2020.
- ↑ McAuliffe, Kathleen (April 27, 2011). "#5: Family Genomics Links DNA to Disease". Discover. January/February 2011.
External links[edit]
- Articles for Jared Roach, at the Institute for Systems Biology
Category:Living people
Category:21st-century American biologists
Category:Cornell University alumni
Category:University of Washington alumni
Category:Systems biologists
Category:Human Genome Project scientists
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